Light and circadian regulation of clock components aids flexible responses to environmental signals.
Bottom Line: However, these and earlier data showed that the O. tauri network retains surprising flexibility, despite its simple circuit.We found that models constructed from experimental data can show flexibility either from multiple loops and/or from multiple light inputs.Our results suggest that O. tauri has adopted the latter strategy, possibly as a consequence of genomic reduction.
Affiliation: SynthSys, University of Edinburgh, Kings Buildings, Mayfield Road, Edinburgh, EH9 3JD, UK; Department of Crop Genetics, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK.Show MeSH
Mentions: The comparison of the calculated flexibility dimensions of the A. thaliana and O. tauri models in constant conditions showed that flexibility increases with the total number of feedback loops in the circuit (Fig. 4). To increase the generality of this analysis, a two-loop model of the N. crassa clock (A2010; Fig. S1c) was also included (Akman et al., 2010). When entrainment was incorporated, the flexibility of each model network also increased. Fig. 4 shows that in LL, the flexibility of the single loop O. tauri (T2011) network (Troein et al., 2011) is close to that of the single loop A. thaliana (L2005A) network (Locke et al., 2005a). However, the addition of light : dark cycles to O. tauri results in a flexibility that is intermediate between the multiloop A. thaliana L2005B (Locke et al., 2005b) and L2006 (Locke et al., 2006) circuits.
Affiliation: SynthSys, University of Edinburgh, Kings Buildings, Mayfield Road, Edinburgh, EH9 3JD, UK; Department of Crop Genetics, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK.