Effects of food on the pharmacokinetics of ponatinib in healthy subjects.
Bottom Line: All limits of the 90% CIs of the estimated geometric mean ratios for Cmax and all AUC comparisons fell within the 80%-125% margins.These results indicate that consumption of a high- or low-fat meal within 30 min prior to administration of ponatinib had no effect on the single-dose pharmacokinetics of ponatinib.Food does not affect the single-dose pharmacokinetics of ponatinib.
Affiliation: ARIAD Pharmaceuticals, Inc., Cambridge, MA, USA.Show MeSH
Related in: MedlinePlus
Mentions: Maximum mean concentrations for the high-fat, low-fat and fasted regimens were reached approximately 5–6 h after oral administration of a single 45-mg ponatinib tablet and were between 51·7 and 54·5 ng/mL. Ponatinib in plasma was quantifiable through the 96-h sampling interval across all three treatment regimens. Notably, there were no differences between the respective absorption and distribution profiles for the three treatment regimens (Fig. 1). Ponatinib plasma concentrations declined in a multi-exponential manner; as expected, the elimination rate was not affected by the food regimen.