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Effects of imatinib mesylate on pulmonary allergic vasculitis in a murine model.

Suzuki N, Sasaki N, Utsumi Y, Nagashima H, Nakamura Y, Yamashita M, Yamauchi K, Sawai T - Int J Rheum Dis (2013)

Bottom Line: In the present study, we examine the effects of IM on vascular remodeling in a murine model of allergic vasculitis with eosinophil infiltration.The number of eosinophils in BALF was reduced significantly in the IM-treated group compared to the positive control.IM-suppressed pulmonary vascular remodeling in a murine model of allergic vasculitis with eosinophil infiltration.

View Article: PubMed Central - PubMed

Affiliation: Division of Pulmonary Medicine, Allergy and Rheumatology, Department of Internal Medicine, Iwate Medical University School of Medicine, Morioka, Japan.

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Related in: MedlinePlus

Effects of imatinib mesylate (IM) on severity of vascular changes. White circle: histological scores of the ovalbumin (OVA)-sensitized mice after the seventh day of exposure to OVA (n = 12) (group C); black circle, the OVA-sensitized mice after the seventh day of exposure to OVA and treated with IM (n = 12) (group D); gray circle, group A. Data are given as mean ± SD and P < 0.01.
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fig04: Effects of imatinib mesylate (IM) on severity of vascular changes. White circle: histological scores of the ovalbumin (OVA)-sensitized mice after the seventh day of exposure to OVA (n = 12) (group C); black circle, the OVA-sensitized mice after the seventh day of exposure to OVA and treated with IM (n = 12) (group D); gray circle, group A. Data are given as mean ± SD and P < 0.01.

Mentions: Almost all small pulmonary arteries were highly obstructed due to the accumulation of cellular components in OVA-exposed mice (group C) (Fig. 3a). Intraluminally accumulated cells were positively stained by anti-actin antibody (data not shown), suggesting characteristics of myofibroblasts in group C. In contrast, the histological changes in IM-treated mice (group D) were markedly reduced (Fig. 3b). Semiquantitative analysis of the histological vascular changes in the mice after the seventh day of OVA-exposure and in those treated with IM was performed as described in Methods in terms of the severity index. The severity index in group D was significantly lower than that in group C (Fig. 4). Histological changes were minimal in groups A and B exposed to saline.


Effects of imatinib mesylate on pulmonary allergic vasculitis in a murine model.

Suzuki N, Sasaki N, Utsumi Y, Nagashima H, Nakamura Y, Yamashita M, Yamauchi K, Sawai T - Int J Rheum Dis (2013)

Effects of imatinib mesylate (IM) on severity of vascular changes. White circle: histological scores of the ovalbumin (OVA)-sensitized mice after the seventh day of exposure to OVA (n = 12) (group C); black circle, the OVA-sensitized mice after the seventh day of exposure to OVA and treated with IM (n = 12) (group D); gray circle, group A. Data are given as mean ± SD and P < 0.01.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4285948&req=5

fig04: Effects of imatinib mesylate (IM) on severity of vascular changes. White circle: histological scores of the ovalbumin (OVA)-sensitized mice after the seventh day of exposure to OVA (n = 12) (group C); black circle, the OVA-sensitized mice after the seventh day of exposure to OVA and treated with IM (n = 12) (group D); gray circle, group A. Data are given as mean ± SD and P < 0.01.
Mentions: Almost all small pulmonary arteries were highly obstructed due to the accumulation of cellular components in OVA-exposed mice (group C) (Fig. 3a). Intraluminally accumulated cells were positively stained by anti-actin antibody (data not shown), suggesting characteristics of myofibroblasts in group C. In contrast, the histological changes in IM-treated mice (group D) were markedly reduced (Fig. 3b). Semiquantitative analysis of the histological vascular changes in the mice after the seventh day of OVA-exposure and in those treated with IM was performed as described in Methods in terms of the severity index. The severity index in group D was significantly lower than that in group C (Fig. 4). Histological changes were minimal in groups A and B exposed to saline.

Bottom Line: In the present study, we examine the effects of IM on vascular remodeling in a murine model of allergic vasculitis with eosinophil infiltration.The number of eosinophils in BALF was reduced significantly in the IM-treated group compared to the positive control.IM-suppressed pulmonary vascular remodeling in a murine model of allergic vasculitis with eosinophil infiltration.

View Article: PubMed Central - PubMed

Affiliation: Division of Pulmonary Medicine, Allergy and Rheumatology, Department of Internal Medicine, Iwate Medical University School of Medicine, Morioka, Japan.

Show MeSH
Related in: MedlinePlus