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ABCB1 gene polymorphisms and glucocorticoid-induced avascular necrosis of the femoral head susceptibility: a meta-analysis.

Li Z, Zhao D, Wang B - Med. Sci. Monit. (2014)

Bottom Line: Significant differences were found for rs1045642 polymorphism in the comparisons of CC vs.G(TA)+(TA)(TA) (OR, 1.548; 95% CI,1.063-2.255; P=0.023).The study demonstrated that the ABCB1 polymorphisms (rs1045642 and rs2032582) significantly reduced the risk of GANFH.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedics, Affiliated Zhongshan Hospital, Dalian University, Dalian, Liaoning, China (mainland).

ABSTRACT

Background: The results of studies on association between ABCB1 gene polymorphisms and glucocorticoid-induced avascular necrosis of the femoral head (GANFH) are controversial. This study aimed to assess the association of ABCB1 gene polymorphisms with the risk of GANFH by conducting a meta-analysis.

Material and methods: The PubMed, Cochrane Library, and Embase databases were searched for papers that describe the association between ABCB1 polymorphisms and GANFH risk. Summary odds ratios and 95% confidence intervals (CI) were estimated based on a fixed-effects model or random-effects model, depending on the absence or presence of significant heterogeneity.

Results: A total of 5 studies and 833 patients were included in the final analysis. Significant differences were found for rs1045642 polymorphism in the comparisons of CC vs. CT+TT (OR, 1.462; 95% CI, 1.066-2.007; P=0.019), and rs2032582 polymorphism in the comparisons of GG vs. G(TA)+(TA)(TA) (OR, 1.548; 95% CI,1.063-2.255; P=0.023).

Conclusions: The study demonstrated that the ABCB1 polymorphisms (rs1045642 and rs2032582) significantly reduced the risk of GANFH.

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Related in: MedlinePlus

Search strategy flow diagram.
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Related In: Results  -  Collection


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f1-medscimonit-20-2811: Search strategy flow diagram.

Mentions: The initial literature search retrieved 22 relevant articles (duplicates were discarded) and 7 articles were excluded for not investigating the topic after carefully screening the titles and abstracts. Then, full publication review was performed, and 2 articles were excluded (1 study of overlapping data, and 1 cell study), which left 5 studies (all case-control studies) for this meta-analysis [14,17–20]. Flowcharts describing the study selection are shown in Figure 1. All included studies were in accordance with the NOS scale and were therefore defined as high-quality studies.


ABCB1 gene polymorphisms and glucocorticoid-induced avascular necrosis of the femoral head susceptibility: a meta-analysis.

Li Z, Zhao D, Wang B - Med. Sci. Monit. (2014)

Search strategy flow diagram.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4285923&req=5

f1-medscimonit-20-2811: Search strategy flow diagram.
Mentions: The initial literature search retrieved 22 relevant articles (duplicates were discarded) and 7 articles were excluded for not investigating the topic after carefully screening the titles and abstracts. Then, full publication review was performed, and 2 articles were excluded (1 study of overlapping data, and 1 cell study), which left 5 studies (all case-control studies) for this meta-analysis [14,17–20]. Flowcharts describing the study selection are shown in Figure 1. All included studies were in accordance with the NOS scale and were therefore defined as high-quality studies.

Bottom Line: Significant differences were found for rs1045642 polymorphism in the comparisons of CC vs.G(TA)+(TA)(TA) (OR, 1.548; 95% CI,1.063-2.255; P=0.023).The study demonstrated that the ABCB1 polymorphisms (rs1045642 and rs2032582) significantly reduced the risk of GANFH.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedics, Affiliated Zhongshan Hospital, Dalian University, Dalian, Liaoning, China (mainland).

ABSTRACT

Background: The results of studies on association between ABCB1 gene polymorphisms and glucocorticoid-induced avascular necrosis of the femoral head (GANFH) are controversial. This study aimed to assess the association of ABCB1 gene polymorphisms with the risk of GANFH by conducting a meta-analysis.

Material and methods: The PubMed, Cochrane Library, and Embase databases were searched for papers that describe the association between ABCB1 polymorphisms and GANFH risk. Summary odds ratios and 95% confidence intervals (CI) were estimated based on a fixed-effects model or random-effects model, depending on the absence or presence of significant heterogeneity.

Results: A total of 5 studies and 833 patients were included in the final analysis. Significant differences were found for rs1045642 polymorphism in the comparisons of CC vs. CT+TT (OR, 1.462; 95% CI, 1.066-2.007; P=0.019), and rs2032582 polymorphism in the comparisons of GG vs. G(TA)+(TA)(TA) (OR, 1.548; 95% CI,1.063-2.255; P=0.023).

Conclusions: The study demonstrated that the ABCB1 polymorphisms (rs1045642 and rs2032582) significantly reduced the risk of GANFH.

Show MeSH
Related in: MedlinePlus