Epigenetics and chromatin remodeling in adult cardiomyopathy.
Bottom Line: Histone modifications and ATP-dependent chromatin remodeling together with DNA methylation are dynamic processes that modify chromatin architecture and profoundly modulate gene expression.Their coordinated control is key to ensuring proper cell commitment and organ development, as well as adaption to environmental cues.Understanding the functional significance of the different epigenetic marks as points of genetic control may represent a promising future therapeutic tool.
Affiliation: Cardiovascular Research Program, King Faisal Specialist Hospital & Research Centre, PO Box 3354, Riyadh, 11211, Kingdom of Saudi Arabia.Show MeSH
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Mentions: Studies from the past two decades have established that local changes in chromatin structure regulate the expression of many eukaryotic genes 23. Chromatin modifications have become integrated into normal gene regulatory pathways. Histones can be modified by post-translational modifications such as acetylation, methylation, phosphorylation and ADP-ribosylation (Figure 1) 4–6. While it is still difficult to decode the specific post-translational modifications at the level of single histones and single nucleosomes, mounting evidence suggests that histone modifications “communicate” and influence one another 23. Epigenomic studies indicate that local changes in chromatin architecture alter specific transcriptional programs and contribute to the development of cardiac pathologies in the adult (Figure 2, Table1).
Affiliation: Cardiovascular Research Program, King Faisal Specialist Hospital & Research Centre, PO Box 3354, Riyadh, 11211, Kingdom of Saudi Arabia.