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Probabilistic classification learning with corrective feedback is associated with in vivo striatal dopamine release in the ventral striatum, while learning without feedback is not.

Wilkinson L, Tai YF, Lin CS, Lagnado DA, Brooks DJ, Piccini P, Jahanshahi M - Hum Brain Mapp (2014)

Bottom Line: Based on a region-of-interest approach, striatal RAC-binding potentials reduced by 13-17% in the right ventral striatum when performing the FB compared to control task, indicating release of synaptic dopamine.In contrast, right ventral striatal RAC binding non-significantly increased by 9% during the PA task.While differences between the FB and PA versions of the WPT in effort and decision-making is also relevant, we conclude striatal dopamine is released during FB-based WPT-learning, implicating the striatum and its dopamine connections in mediating learning with FB.

View Article: PubMed Central - PubMed

Affiliation: Cognitive Motor Neuroscience Group, Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, United Kingdom.

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11C-Racolpride binding data. Mean percentage change in 11C-raclopride binding potential (RAC BPND) across different regions in the striatum, plotted separately for feedback (FB) and paired associate (PA) groups. Percentage change is defined for each group as RAC BPND change in ‘active’ (i.e., FB or PA) relative to ‘control’ task. A decrease in percent change of RAC BPND is indicative of greater release of synaptic dopamine in that region. Error bars are standard error. R = right, L = left. Caud = caudate, put = putamen, VS = ventral striatum. An asterisk indicates a significant comparison.
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fig06: 11C-Racolpride binding data. Mean percentage change in 11C-raclopride binding potential (RAC BPND) across different regions in the striatum, plotted separately for feedback (FB) and paired associate (PA) groups. Percentage change is defined for each group as RAC BPND change in ‘active’ (i.e., FB or PA) relative to ‘control’ task. A decrease in percent change of RAC BPND is indicative of greater release of synaptic dopamine in that region. Error bars are standard error. R = right, L = left. Caud = caudate, put = putamen, VS = ventral striatum. An asterisk indicates a significant comparison.

Mentions: Figure 6 shows mean percentage change in striatal RAC BPND, for all six regions and plotted separately for the two groups. Mean percent change in RAC BPND was significantly different between the groups in the right ventral striatum [t(13) = −2.33, P = 0.04, Cohen's d = 1.5], with the left ventral striatum on the borderline of statistical significance [t(13) = −1.88, P = 0.08]. All other comparisons between the groups were not significant (ts < 1).


Probabilistic classification learning with corrective feedback is associated with in vivo striatal dopamine release in the ventral striatum, while learning without feedback is not.

Wilkinson L, Tai YF, Lin CS, Lagnado DA, Brooks DJ, Piccini P, Jahanshahi M - Hum Brain Mapp (2014)

11C-Racolpride binding data. Mean percentage change in 11C-raclopride binding potential (RAC BPND) across different regions in the striatum, plotted separately for feedback (FB) and paired associate (PA) groups. Percentage change is defined for each group as RAC BPND change in ‘active’ (i.e., FB or PA) relative to ‘control’ task. A decrease in percent change of RAC BPND is indicative of greater release of synaptic dopamine in that region. Error bars are standard error. R = right, L = left. Caud = caudate, put = putamen, VS = ventral striatum. An asterisk indicates a significant comparison.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4285817&req=5

fig06: 11C-Racolpride binding data. Mean percentage change in 11C-raclopride binding potential (RAC BPND) across different regions in the striatum, plotted separately for feedback (FB) and paired associate (PA) groups. Percentage change is defined for each group as RAC BPND change in ‘active’ (i.e., FB or PA) relative to ‘control’ task. A decrease in percent change of RAC BPND is indicative of greater release of synaptic dopamine in that region. Error bars are standard error. R = right, L = left. Caud = caudate, put = putamen, VS = ventral striatum. An asterisk indicates a significant comparison.
Mentions: Figure 6 shows mean percentage change in striatal RAC BPND, for all six regions and plotted separately for the two groups. Mean percent change in RAC BPND was significantly different between the groups in the right ventral striatum [t(13) = −2.33, P = 0.04, Cohen's d = 1.5], with the left ventral striatum on the borderline of statistical significance [t(13) = −1.88, P = 0.08]. All other comparisons between the groups were not significant (ts < 1).

Bottom Line: Based on a region-of-interest approach, striatal RAC-binding potentials reduced by 13-17% in the right ventral striatum when performing the FB compared to control task, indicating release of synaptic dopamine.In contrast, right ventral striatal RAC binding non-significantly increased by 9% during the PA task.While differences between the FB and PA versions of the WPT in effort and decision-making is also relevant, we conclude striatal dopamine is released during FB-based WPT-learning, implicating the striatum and its dopamine connections in mediating learning with FB.

View Article: PubMed Central - PubMed

Affiliation: Cognitive Motor Neuroscience Group, Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, United Kingdom.

Show MeSH
Related in: MedlinePlus