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Probabilistic classification learning with corrective feedback is associated with in vivo striatal dopamine release in the ventral striatum, while learning without feedback is not.

Wilkinson L, Tai YF, Lin CS, Lagnado DA, Brooks DJ, Piccini P, Jahanshahi M - Hum Brain Mapp (2014)

Bottom Line: Based on a region-of-interest approach, striatal RAC-binding potentials reduced by 13-17% in the right ventral striatum when performing the FB compared to control task, indicating release of synaptic dopamine.In contrast, right ventral striatal RAC binding non-significantly increased by 9% during the PA task.While differences between the FB and PA versions of the WPT in effort and decision-making is also relevant, we conclude striatal dopamine is released during FB-based WPT-learning, implicating the striatum and its dopamine connections in mediating learning with FB.

View Article: PubMed Central - PubMed

Affiliation: Cognitive Motor Neuroscience Group, Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, United Kingdom.

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An example of a screen presented to participants during the training phase of the feedback-based weather prediction task. The ‘thumbs up’ sign indicates a correct response. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]
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fig02: An example of a screen presented to participants during the training phase of the feedback-based weather prediction task. The ‘thumbs up’ sign indicates a correct response. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]

Mentions: On each trial participants were presented with an arrangement of cards (see Apparatus & materials), the cards appeared on the screen for a total of 7 s. During this time, participants were asked to predict the weather on that trial, which required them to classify the card arrangement into one of the two possible outcomes, rainy or fine; responses were made via two response buttons on a response pad. Following their response, feedback appeared on the screen depending on whether the response was correct (thumbs up) or incorrect (thumbs down) (Fig. 2). The feedback and the card arrangement both remained on the screen for the remainder of the 7-s period after which they disappeared. This was followed by a blank screen for 2 s before the next combination of cards were presented. If participants failed to make a response, the card arrangement appeared on the screen for the duration of 7 s but no feedback was provided. There were 400 training trials. The task started 5 min before injection of tracer and ended 5 min before completion of RAC PET (total duration 60 min). Participants' performance on the last 50 training trials was used to assess how much they had learned the cue-outcome probabilities.


Probabilistic classification learning with corrective feedback is associated with in vivo striatal dopamine release in the ventral striatum, while learning without feedback is not.

Wilkinson L, Tai YF, Lin CS, Lagnado DA, Brooks DJ, Piccini P, Jahanshahi M - Hum Brain Mapp (2014)

An example of a screen presented to participants during the training phase of the feedback-based weather prediction task. The ‘thumbs up’ sign indicates a correct response. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4285817&req=5

fig02: An example of a screen presented to participants during the training phase of the feedback-based weather prediction task. The ‘thumbs up’ sign indicates a correct response. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]
Mentions: On each trial participants were presented with an arrangement of cards (see Apparatus & materials), the cards appeared on the screen for a total of 7 s. During this time, participants were asked to predict the weather on that trial, which required them to classify the card arrangement into one of the two possible outcomes, rainy or fine; responses were made via two response buttons on a response pad. Following their response, feedback appeared on the screen depending on whether the response was correct (thumbs up) or incorrect (thumbs down) (Fig. 2). The feedback and the card arrangement both remained on the screen for the remainder of the 7-s period after which they disappeared. This was followed by a blank screen for 2 s before the next combination of cards were presented. If participants failed to make a response, the card arrangement appeared on the screen for the duration of 7 s but no feedback was provided. There were 400 training trials. The task started 5 min before injection of tracer and ended 5 min before completion of RAC PET (total duration 60 min). Participants' performance on the last 50 training trials was used to assess how much they had learned the cue-outcome probabilities.

Bottom Line: Based on a region-of-interest approach, striatal RAC-binding potentials reduced by 13-17% in the right ventral striatum when performing the FB compared to control task, indicating release of synaptic dopamine.In contrast, right ventral striatal RAC binding non-significantly increased by 9% during the PA task.While differences between the FB and PA versions of the WPT in effort and decision-making is also relevant, we conclude striatal dopamine is released during FB-based WPT-learning, implicating the striatum and its dopamine connections in mediating learning with FB.

View Article: PubMed Central - PubMed

Affiliation: Cognitive Motor Neuroscience Group, Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, United Kingdom.

Show MeSH
Related in: MedlinePlus