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Endovascular method for transplantation of insulin-producing cells to the pancreas parenchyma in swine.

Lundberg J, Stone-Elander S, Zhang XM, Korsgren O, Jonsson S, Holmin S - Am. J. Transplant. (2014)

Bottom Line: In this experiment, we accessed the extra-vascular pancreatic parenchyma in swine by microendovascular technique and injected methylene blue, contrast fluids and insulin-producing cells without acute adverse events.Further, we evaluated the procedure itself by a 1-year angiographical follow-up, without adverse events.In clinical practice, the potential benefits compared to portal vein cell transplantation should significantly improve endocrine function of the graft and potentially reduce adverse events.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden.

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Radiological images from the trans-vessel wall intervention in the pancreas and an angiographic follow-up 1 year later. (A) An example of a CT reconstruction with axial orientation from the XperCT algorithm reconstructed from raw data of the C-arm. (B) A 3D reconstruction of the aorta, celiac trunk and the posterior pancreatic artery (PPA), marked with arrow. Also marked are the proper hepatic artery (PHA) and splenic artery (SA). (C) Primary intervention within the PPA segment followed with (D), the same vessel 1 year later.
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fig01: Radiological images from the trans-vessel wall intervention in the pancreas and an angiographic follow-up 1 year later. (A) An example of a CT reconstruction with axial orientation from the XperCT algorithm reconstructed from raw data of the C-arm. (B) A 3D reconstruction of the aorta, celiac trunk and the posterior pancreatic artery (PPA), marked with arrow. Also marked are the proper hepatic artery (PHA) and splenic artery (SA). (C) Primary intervention within the PPA segment followed with (D), the same vessel 1 year later.

Mentions: We first evaluated the trans-vessel wall approach in several acute settings in Swedish rural swine (nā€‰=ā€‰4). We could preoperatively determine the abdominal organ anatomy and vascular supply with contrast-enhanced XperCT scans 18 (Figure 1). The vascular supply of the pancreas was successfully visualized by high-resolution DSA for navigation to the posterior pancreatic artery (PPA) (Figure 1). Both vessel trunks were deemed suitable for trans-vessel wall intervention. The basic anatomy corresponded well with the literature 19.


Endovascular method for transplantation of insulin-producing cells to the pancreas parenchyma in swine.

Lundberg J, Stone-Elander S, Zhang XM, Korsgren O, Jonsson S, Holmin S - Am. J. Transplant. (2014)

Radiological images from the trans-vessel wall intervention in the pancreas and an angiographic follow-up 1 year later. (A) An example of a CT reconstruction with axial orientation from the XperCT algorithm reconstructed from raw data of the C-arm. (B) A 3D reconstruction of the aorta, celiac trunk and the posterior pancreatic artery (PPA), marked with arrow. Also marked are the proper hepatic artery (PHA) and splenic artery (SA). (C) Primary intervention within the PPA segment followed with (D), the same vessel 1 year later.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4285323&req=5

fig01: Radiological images from the trans-vessel wall intervention in the pancreas and an angiographic follow-up 1 year later. (A) An example of a CT reconstruction with axial orientation from the XperCT algorithm reconstructed from raw data of the C-arm. (B) A 3D reconstruction of the aorta, celiac trunk and the posterior pancreatic artery (PPA), marked with arrow. Also marked are the proper hepatic artery (PHA) and splenic artery (SA). (C) Primary intervention within the PPA segment followed with (D), the same vessel 1 year later.
Mentions: We first evaluated the trans-vessel wall approach in several acute settings in Swedish rural swine (nā€‰=ā€‰4). We could preoperatively determine the abdominal organ anatomy and vascular supply with contrast-enhanced XperCT scans 18 (Figure 1). The vascular supply of the pancreas was successfully visualized by high-resolution DSA for navigation to the posterior pancreatic artery (PPA) (Figure 1). Both vessel trunks were deemed suitable for trans-vessel wall intervention. The basic anatomy corresponded well with the literature 19.

Bottom Line: In this experiment, we accessed the extra-vascular pancreatic parenchyma in swine by microendovascular technique and injected methylene blue, contrast fluids and insulin-producing cells without acute adverse events.Further, we evaluated the procedure itself by a 1-year angiographical follow-up, without adverse events.In clinical practice, the potential benefits compared to portal vein cell transplantation should significantly improve endocrine function of the graft and potentially reduce adverse events.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden.

Show MeSH
Related in: MedlinePlus