Endovascular method for transplantation of insulin-producing cells to the pancreas parenchyma in swine.
Bottom Line: In this experiment, we accessed the extra-vascular pancreatic parenchyma in swine by microendovascular technique and injected methylene blue, contrast fluids and insulin-producing cells without acute adverse events.Further, we evaluated the procedure itself by a 1-year angiographical follow-up, without adverse events.In clinical practice, the potential benefits compared to portal vein cell transplantation should significantly improve endocrine function of the graft and potentially reduce adverse events.
Affiliation: Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden.Show MeSH
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Mentions: We first evaluated the trans-vessel wall approach in several acute settings in Swedish rural swine (n = 4). We could preoperatively determine the abdominal organ anatomy and vascular supply with contrast-enhanced XperCT scans 18 (Figure 1). The vascular supply of the pancreas was successfully visualized by high-resolution DSA for navigation to the posterior pancreatic artery (PPA) (Figure 1). Both vessel trunks were deemed suitable for trans-vessel wall intervention. The basic anatomy corresponded well with the literature 19.
Affiliation: Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden.