Limits...
Auditory spatial processing in Alzheimer's disease.

Golden HL, Nicholas JM, Yong KX, Downey LE, Schott JM, Mummery CJ, Crutch SJ, Warren JD - Brain (2014)

Bottom Line: The location and motion of sounds in space are important cues for encoding the auditory world.Relative to healthy older controls, both patient groups exhibited impairments in detection of auditory motion, and stationary sound position discrimination.These findings delineate auditory spatial processing deficits in typical and posterior Alzheimer's disease phenotypes that are related to posterior cortical regions involved in both syndromic variants and modulated by the syndromic profile of brain degeneration.

View Article: PubMed Central - PubMed

Affiliation: 1 Dementia Research Centre, UCL Institute of Neurology, University College London, London, WC1N 3BG, UK.

Show MeSH

Related in: MedlinePlus

Discriminability by parameter level. Mean d-prime scores are plotted for each perceptual parameter level/condition for the moving versus stationary and stationary sound position discrimination tasks. Unbroken lines represent healthy controls; dotted lines the patient group with a typical syndrome of Alzheimer’s disease (tAD); and dashed lines the patient group with a syndrome of posterior cortical atrophy (PCA).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4285196&req=5

awu337-F3: Discriminability by parameter level. Mean d-prime scores are plotted for each perceptual parameter level/condition for the moving versus stationary and stationary sound position discrimination tasks. Unbroken lines represent healthy controls; dotted lines the patient group with a typical syndrome of Alzheimer’s disease (tAD); and dashed lines the patient group with a syndrome of posterior cortical atrophy (PCA).

Mentions: Across groups, performance on the moving versus stationary sound discrimination and timbre discrimination tests was correlated with the prescribed task difficulty level (magnitude of the relevant stimulus parameter); whereas performance on the stationary sound position discrimination test was not monotonically related to perceptual parameter level but rather showed a falling off of discriminability at the largest spatial separation (Fig. 3; d-prime values in Supplementary Table 3).Figure 3


Auditory spatial processing in Alzheimer's disease.

Golden HL, Nicholas JM, Yong KX, Downey LE, Schott JM, Mummery CJ, Crutch SJ, Warren JD - Brain (2014)

Discriminability by parameter level. Mean d-prime scores are plotted for each perceptual parameter level/condition for the moving versus stationary and stationary sound position discrimination tasks. Unbroken lines represent healthy controls; dotted lines the patient group with a typical syndrome of Alzheimer’s disease (tAD); and dashed lines the patient group with a syndrome of posterior cortical atrophy (PCA).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4285196&req=5

awu337-F3: Discriminability by parameter level. Mean d-prime scores are plotted for each perceptual parameter level/condition for the moving versus stationary and stationary sound position discrimination tasks. Unbroken lines represent healthy controls; dotted lines the patient group with a typical syndrome of Alzheimer’s disease (tAD); and dashed lines the patient group with a syndrome of posterior cortical atrophy (PCA).
Mentions: Across groups, performance on the moving versus stationary sound discrimination and timbre discrimination tests was correlated with the prescribed task difficulty level (magnitude of the relevant stimulus parameter); whereas performance on the stationary sound position discrimination test was not monotonically related to perceptual parameter level but rather showed a falling off of discriminability at the largest spatial separation (Fig. 3; d-prime values in Supplementary Table 3).Figure 3

Bottom Line: The location and motion of sounds in space are important cues for encoding the auditory world.Relative to healthy older controls, both patient groups exhibited impairments in detection of auditory motion, and stationary sound position discrimination.These findings delineate auditory spatial processing deficits in typical and posterior Alzheimer's disease phenotypes that are related to posterior cortical regions involved in both syndromic variants and modulated by the syndromic profile of brain degeneration.

View Article: PubMed Central - PubMed

Affiliation: 1 Dementia Research Centre, UCL Institute of Neurology, University College London, London, WC1N 3BG, UK.

Show MeSH
Related in: MedlinePlus