Auditory spatial processing in Alzheimer's disease.
Bottom Line: The location and motion of sounds in space are important cues for encoding the auditory world.Relative to healthy older controls, both patient groups exhibited impairments in detection of auditory motion, and stationary sound position discrimination.These findings delineate auditory spatial processing deficits in typical and posterior Alzheimer's disease phenotypes that are related to posterior cortical regions involved in both syndromic variants and modulated by the syndromic profile of brain degeneration.
Affiliation: 1 Dementia Research Centre, UCL Institute of Neurology, University College London, London, WC1N 3BG, UK.Show MeSH
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Mentions: Across groups, performance on the moving versus stationary sound discrimination and timbre discrimination tests was correlated with the prescribed task difficulty level (magnitude of the relevant stimulus parameter); whereas performance on the stationary sound position discrimination test was not monotonically related to perceptual parameter level but rather showed a falling off of discriminability at the largest spatial separation (Fig. 3; d-prime values in Supplementary Table 3).Figure 3
Affiliation: 1 Dementia Research Centre, UCL Institute of Neurology, University College London, London, WC1N 3BG, UK.