Motion area V5/MT+ response to global motion in the absence of V1 resembles early visual cortex.
Bottom Line: It also confirms predictions that V1 is critically involved in normal V5/MT+ global motion processing, consistent with a convergent model of V1 input to V5/MT+.Historically, most attempts to model cortical visual responses do not consider the contribution of direct subcortical inputs that may bypass striate cortex, such as input to V5/MT+.We have shown that the signal change driven by these non-striate pathways can be measured, and suggest that models of the intact visual system may benefit from considering their contribution.
Affiliation: 1 FMRIB Centre, University of Oxford, UK 2 Nuffield Department of Clinical Neurosciences, University of Oxford, UK firstname.lastname@example.org.Show MeSH
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Mentions: Using this model, we are able to account for 98% of the variance in control V5/MT+ functional MRI signal change (Fig. 5). This equation can also be rearranged to model the abnormal V5/MT+ responses in patients, defined by a loss of the positive linear component in control V5/MT+ responses, which also accurately predicts the data (R2 = 0.93), or indeed the positive linear component itself (R2 = 0.98).Figure 5
Affiliation: 1 FMRIB Centre, University of Oxford, UK 2 Nuffield Department of Clinical Neurosciences, University of Oxford, UK email@example.com.