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Chronic pramipexole treatment increases tolerance for sucrose in normal and ventral tegmental lesioned rats.

Dardou D, Chassain C, Durif F - Front Neurosci (2015)

Bottom Line: In the present study, we performed an intermittent daily feeding experiment to assess the effect of chronic treatment by pramipexole and VTA bilateral lesion on tolerance for sucrose solution.In addition, we noted that the change in sucrose consumption was sustained by an increase of the expression of the Dopamine D3 receptor in the core and the shell regions of the nucleus accumbens.The present results may suggest that long-term stimulation of the Dopamine D3 receptor in animals induces a strong increase in sucrose consumption, indicating an effect of this receptor on certain pathological aspects of food eating.

View Article: PubMed Central - PubMed

Affiliation: EA7280 NPSY-Sydo, Université d'Auvergne Clermont-Ferrand, France.

ABSTRACT
The loss of dopamine neurons observed in Parkinson's disease (PD) elicits severe motor control deficits which are reduced by the use of dopamine agonists. However, recent works have indicated that D3-preferential agonists such as pramipexole can induce impulse control disorders (ICDs) such as food craving or compulsive eating. In the present study, we performed an intermittent daily feeding experiment to assess the effect of chronic treatment by pramipexole and VTA bilateral lesion on tolerance for sucrose solution. The impact of such chronic treatment on spontaneous locomotion and spatial memory was also examined. Changes in sucrose tolerance could indicate the potential development of a change in food compulsion or addiction related to the action of pramipexole. Neither the bilateral lesion of the VTA nor chronic treatment with pramipexole altered the spontaneous locomotion or spatial memory in rats. Rats without pramipexole treatment quickly developed a stable intake of sucrose solution in the 12 h access phase. On the contrary, when under daily pramipexole treatment, rats developed a stronger and ongoing escalation of their sucrose solution intakes. In addition, we noted that the change in sucrose consumption was sustained by an increase of the expression of the Dopamine D3 receptor in the core and the shell regions of the nucleus accumbens. The present results may suggest that long-term stimulation of the Dopamine D3 receptor in animals induces a strong increase in sucrose consumption, indicating an effect of this receptor on certain pathological aspects of food eating.

No MeSH data available.


Related in: MedlinePlus

Sucrose solution consumption during intermittent daily feeding. Intake of the 10% sucrose solution escalates over the 19 days (A) whatever the group considered. Since the consumption of L rats (white triangle and black dash line) and Sh rats (white circles and gray dash line) escalated slowly and stabilized, the intake of Sh-PPX (gray circles and gray bold line) and L-PPX (black triangle and black bold line) rats increased quickly over days. The • represent significant (p < 0.05) and •• significant (p < 0.001) difference between L and L-PPX rats, the # indicated that Sh-PPx rats were significant (p < 0.05) different from L ones. The black number indicates significant (p < 0.05) difference with previous days for L-PPX rats, the gray one is for Sh-PPX group. For example the sucrose intake of L-PPX rats was significantly (p < 0.05) higher in day 14 compared to day 1, 2, 3, and 5. The area under curves (A.U.C.) analysis (B) showed that L-PPX group was significantly (* p<0.05) higher compared to L rats. The intake of 10% sucrose solution of each animals and the mean of each group was represented to observe the potential distribution of rats (C). L-PPX rats: black triangles, L Rats: white triangles, Sh-PPX rats: gray circles and Sh rats: white circles. Sh: Sham animals, Sh-PPX: sham animals with daily pramipexole treatment (0.1 mg/kg/day), L: VTA lesioned rats, L-PPX: VTA lesioned rats with daily pramipexole treatment (0.1 mg/kg/day).
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Figure 4: Sucrose solution consumption during intermittent daily feeding. Intake of the 10% sucrose solution escalates over the 19 days (A) whatever the group considered. Since the consumption of L rats (white triangle and black dash line) and Sh rats (white circles and gray dash line) escalated slowly and stabilized, the intake of Sh-PPX (gray circles and gray bold line) and L-PPX (black triangle and black bold line) rats increased quickly over days. The • represent significant (p < 0.05) and •• significant (p < 0.001) difference between L and L-PPX rats, the # indicated that Sh-PPx rats were significant (p < 0.05) different from L ones. The black number indicates significant (p < 0.05) difference with previous days for L-PPX rats, the gray one is for Sh-PPX group. For example the sucrose intake of L-PPX rats was significantly (p < 0.05) higher in day 14 compared to day 1, 2, 3, and 5. The area under curves (A.U.C.) analysis (B) showed that L-PPX group was significantly (* p<0.05) higher compared to L rats. The intake of 10% sucrose solution of each animals and the mean of each group was represented to observe the potential distribution of rats (C). L-PPX rats: black triangles, L Rats: white triangles, Sh-PPX rats: gray circles and Sh rats: white circles. Sh: Sham animals, Sh-PPX: sham animals with daily pramipexole treatment (0.1 mg/kg/day), L: VTA lesioned rats, L-PPX: VTA lesioned rats with daily pramipexole treatment (0.1 mg/kg/day).

Mentions: The daily intake of a 10% sucrose solution for the 12 h of the dark period escalated over the days, irrespective of the experimental group considered (Figure 4A). The Two-Way ANOVA for repeated measures indicated a significant effect of treatment [F(1, 43) = 8.56; p < 0.05], a significant effect of repetition [F(18, 774) = 26.8; p < 0.0001] and an interaction between repetition and treatment [F(18, 774) = 7.48; p < 0.0001]. An additional analysis using a One-Way ANOVA with day as factor for each group indicated an effect only in L-PPX and Sh-PPX [respectively F(18, 246) = 9.15; p < 0.0001 and F(18, 208) = 7.91; p < 0.0001].


Chronic pramipexole treatment increases tolerance for sucrose in normal and ventral tegmental lesioned rats.

Dardou D, Chassain C, Durif F - Front Neurosci (2015)

Sucrose solution consumption during intermittent daily feeding. Intake of the 10% sucrose solution escalates over the 19 days (A) whatever the group considered. Since the consumption of L rats (white triangle and black dash line) and Sh rats (white circles and gray dash line) escalated slowly and stabilized, the intake of Sh-PPX (gray circles and gray bold line) and L-PPX (black triangle and black bold line) rats increased quickly over days. The • represent significant (p < 0.05) and •• significant (p < 0.001) difference between L and L-PPX rats, the # indicated that Sh-PPx rats were significant (p < 0.05) different from L ones. The black number indicates significant (p < 0.05) difference with previous days for L-PPX rats, the gray one is for Sh-PPX group. For example the sucrose intake of L-PPX rats was significantly (p < 0.05) higher in day 14 compared to day 1, 2, 3, and 5. The area under curves (A.U.C.) analysis (B) showed that L-PPX group was significantly (* p<0.05) higher compared to L rats. The intake of 10% sucrose solution of each animals and the mean of each group was represented to observe the potential distribution of rats (C). L-PPX rats: black triangles, L Rats: white triangles, Sh-PPX rats: gray circles and Sh rats: white circles. Sh: Sham animals, Sh-PPX: sham animals with daily pramipexole treatment (0.1 mg/kg/day), L: VTA lesioned rats, L-PPX: VTA lesioned rats with daily pramipexole treatment (0.1 mg/kg/day).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4285017&req=5

Figure 4: Sucrose solution consumption during intermittent daily feeding. Intake of the 10% sucrose solution escalates over the 19 days (A) whatever the group considered. Since the consumption of L rats (white triangle and black dash line) and Sh rats (white circles and gray dash line) escalated slowly and stabilized, the intake of Sh-PPX (gray circles and gray bold line) and L-PPX (black triangle and black bold line) rats increased quickly over days. The • represent significant (p < 0.05) and •• significant (p < 0.001) difference between L and L-PPX rats, the # indicated that Sh-PPx rats were significant (p < 0.05) different from L ones. The black number indicates significant (p < 0.05) difference with previous days for L-PPX rats, the gray one is for Sh-PPX group. For example the sucrose intake of L-PPX rats was significantly (p < 0.05) higher in day 14 compared to day 1, 2, 3, and 5. The area under curves (A.U.C.) analysis (B) showed that L-PPX group was significantly (* p<0.05) higher compared to L rats. The intake of 10% sucrose solution of each animals and the mean of each group was represented to observe the potential distribution of rats (C). L-PPX rats: black triangles, L Rats: white triangles, Sh-PPX rats: gray circles and Sh rats: white circles. Sh: Sham animals, Sh-PPX: sham animals with daily pramipexole treatment (0.1 mg/kg/day), L: VTA lesioned rats, L-PPX: VTA lesioned rats with daily pramipexole treatment (0.1 mg/kg/day).
Mentions: The daily intake of a 10% sucrose solution for the 12 h of the dark period escalated over the days, irrespective of the experimental group considered (Figure 4A). The Two-Way ANOVA for repeated measures indicated a significant effect of treatment [F(1, 43) = 8.56; p < 0.05], a significant effect of repetition [F(18, 774) = 26.8; p < 0.0001] and an interaction between repetition and treatment [F(18, 774) = 7.48; p < 0.0001]. An additional analysis using a One-Way ANOVA with day as factor for each group indicated an effect only in L-PPX and Sh-PPX [respectively F(18, 246) = 9.15; p < 0.0001 and F(18, 208) = 7.91; p < 0.0001].

Bottom Line: In the present study, we performed an intermittent daily feeding experiment to assess the effect of chronic treatment by pramipexole and VTA bilateral lesion on tolerance for sucrose solution.In addition, we noted that the change in sucrose consumption was sustained by an increase of the expression of the Dopamine D3 receptor in the core and the shell regions of the nucleus accumbens.The present results may suggest that long-term stimulation of the Dopamine D3 receptor in animals induces a strong increase in sucrose consumption, indicating an effect of this receptor on certain pathological aspects of food eating.

View Article: PubMed Central - PubMed

Affiliation: EA7280 NPSY-Sydo, Université d'Auvergne Clermont-Ferrand, France.

ABSTRACT
The loss of dopamine neurons observed in Parkinson's disease (PD) elicits severe motor control deficits which are reduced by the use of dopamine agonists. However, recent works have indicated that D3-preferential agonists such as pramipexole can induce impulse control disorders (ICDs) such as food craving or compulsive eating. In the present study, we performed an intermittent daily feeding experiment to assess the effect of chronic treatment by pramipexole and VTA bilateral lesion on tolerance for sucrose solution. The impact of such chronic treatment on spontaneous locomotion and spatial memory was also examined. Changes in sucrose tolerance could indicate the potential development of a change in food compulsion or addiction related to the action of pramipexole. Neither the bilateral lesion of the VTA nor chronic treatment with pramipexole altered the spontaneous locomotion or spatial memory in rats. Rats without pramipexole treatment quickly developed a stable intake of sucrose solution in the 12 h access phase. On the contrary, when under daily pramipexole treatment, rats developed a stronger and ongoing escalation of their sucrose solution intakes. In addition, we noted that the change in sucrose consumption was sustained by an increase of the expression of the Dopamine D3 receptor in the core and the shell regions of the nucleus accumbens. The present results may suggest that long-term stimulation of the Dopamine D3 receptor in animals induces a strong increase in sucrose consumption, indicating an effect of this receptor on certain pathological aspects of food eating.

No MeSH data available.


Related in: MedlinePlus