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Chronic pramipexole treatment increases tolerance for sucrose in normal and ventral tegmental lesioned rats.

Dardou D, Chassain C, Durif F - Front Neurosci (2015)

Bottom Line: In the present study, we performed an intermittent daily feeding experiment to assess the effect of chronic treatment by pramipexole and VTA bilateral lesion on tolerance for sucrose solution.In addition, we noted that the change in sucrose consumption was sustained by an increase of the expression of the Dopamine D3 receptor in the core and the shell regions of the nucleus accumbens.The present results may suggest that long-term stimulation of the Dopamine D3 receptor in animals induces a strong increase in sucrose consumption, indicating an effect of this receptor on certain pathological aspects of food eating.

View Article: PubMed Central - PubMed

Affiliation: EA7280 NPSY-Sydo, Université d'Auvergne Clermont-Ferrand, France.

ABSTRACT
The loss of dopamine neurons observed in Parkinson's disease (PD) elicits severe motor control deficits which are reduced by the use of dopamine agonists. However, recent works have indicated that D3-preferential agonists such as pramipexole can induce impulse control disorders (ICDs) such as food craving or compulsive eating. In the present study, we performed an intermittent daily feeding experiment to assess the effect of chronic treatment by pramipexole and VTA bilateral lesion on tolerance for sucrose solution. The impact of such chronic treatment on spontaneous locomotion and spatial memory was also examined. Changes in sucrose tolerance could indicate the potential development of a change in food compulsion or addiction related to the action of pramipexole. Neither the bilateral lesion of the VTA nor chronic treatment with pramipexole altered the spontaneous locomotion or spatial memory in rats. Rats without pramipexole treatment quickly developed a stable intake of sucrose solution in the 12 h access phase. On the contrary, when under daily pramipexole treatment, rats developed a stronger and ongoing escalation of their sucrose solution intakes. In addition, we noted that the change in sucrose consumption was sustained by an increase of the expression of the Dopamine D3 receptor in the core and the shell regions of the nucleus accumbens. The present results may suggest that long-term stimulation of the Dopamine D3 receptor in animals induces a strong increase in sucrose consumption, indicating an effect of this receptor on certain pathological aspects of food eating.

No MeSH data available.


Related in: MedlinePlus

Daily administration of pramipexole (PPX) has no effect on spontaneous locomotors activity and spontaneous alternation Y maze. Spontaneous locomotor activity (A) and rearing (B) were not affected by the VTA lesion (white bars) or by 1 week of daily administration of PPX (gray bars) whatever the experimental group considered. The alternation score measure in Y maze (C) was not modified by neither the lesion (white bars) nor 1 week of daily PPX administration (gray bars). Sh, Sham animals; Sh-PPX, sham animals with daily pramipexole treatment (0.1 mg/kg/day); L, VTA lesioned rats; L-PPX, VTA lesioned rats with daily pramipexole treatment (0.1 mg/kg/day).
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Figure 3: Daily administration of pramipexole (PPX) has no effect on spontaneous locomotors activity and spontaneous alternation Y maze. Spontaneous locomotor activity (A) and rearing (B) were not affected by the VTA lesion (white bars) or by 1 week of daily administration of PPX (gray bars) whatever the experimental group considered. The alternation score measure in Y maze (C) was not modified by neither the lesion (white bars) nor 1 week of daily PPX administration (gray bars). Sh, Sham animals; Sh-PPX, sham animals with daily pramipexole treatment (0.1 mg/kg/day); L, VTA lesioned rats; L-PPX, VTA lesioned rats with daily pramipexole treatment (0.1 mg/kg/day).

Mentions: Spontaneous locomotor activity in the open field. The Two-Way ANOVA with repeated measures did not show a significant effect of factors on the mean distance run in the open field arena (Figure 3A) or the amount of rearing (Figure 3B). Overall, the PPX daily administration had no impact on the locomotor activity of rats, whether they were lesioned or not.


Chronic pramipexole treatment increases tolerance for sucrose in normal and ventral tegmental lesioned rats.

Dardou D, Chassain C, Durif F - Front Neurosci (2015)

Daily administration of pramipexole (PPX) has no effect on spontaneous locomotors activity and spontaneous alternation Y maze. Spontaneous locomotor activity (A) and rearing (B) were not affected by the VTA lesion (white bars) or by 1 week of daily administration of PPX (gray bars) whatever the experimental group considered. The alternation score measure in Y maze (C) was not modified by neither the lesion (white bars) nor 1 week of daily PPX administration (gray bars). Sh, Sham animals; Sh-PPX, sham animals with daily pramipexole treatment (0.1 mg/kg/day); L, VTA lesioned rats; L-PPX, VTA lesioned rats with daily pramipexole treatment (0.1 mg/kg/day).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4285017&req=5

Figure 3: Daily administration of pramipexole (PPX) has no effect on spontaneous locomotors activity and spontaneous alternation Y maze. Spontaneous locomotor activity (A) and rearing (B) were not affected by the VTA lesion (white bars) or by 1 week of daily administration of PPX (gray bars) whatever the experimental group considered. The alternation score measure in Y maze (C) was not modified by neither the lesion (white bars) nor 1 week of daily PPX administration (gray bars). Sh, Sham animals; Sh-PPX, sham animals with daily pramipexole treatment (0.1 mg/kg/day); L, VTA lesioned rats; L-PPX, VTA lesioned rats with daily pramipexole treatment (0.1 mg/kg/day).
Mentions: Spontaneous locomotor activity in the open field. The Two-Way ANOVA with repeated measures did not show a significant effect of factors on the mean distance run in the open field arena (Figure 3A) or the amount of rearing (Figure 3B). Overall, the PPX daily administration had no impact on the locomotor activity of rats, whether they were lesioned or not.

Bottom Line: In the present study, we performed an intermittent daily feeding experiment to assess the effect of chronic treatment by pramipexole and VTA bilateral lesion on tolerance for sucrose solution.In addition, we noted that the change in sucrose consumption was sustained by an increase of the expression of the Dopamine D3 receptor in the core and the shell regions of the nucleus accumbens.The present results may suggest that long-term stimulation of the Dopamine D3 receptor in animals induces a strong increase in sucrose consumption, indicating an effect of this receptor on certain pathological aspects of food eating.

View Article: PubMed Central - PubMed

Affiliation: EA7280 NPSY-Sydo, Université d'Auvergne Clermont-Ferrand, France.

ABSTRACT
The loss of dopamine neurons observed in Parkinson's disease (PD) elicits severe motor control deficits which are reduced by the use of dopamine agonists. However, recent works have indicated that D3-preferential agonists such as pramipexole can induce impulse control disorders (ICDs) such as food craving or compulsive eating. In the present study, we performed an intermittent daily feeding experiment to assess the effect of chronic treatment by pramipexole and VTA bilateral lesion on tolerance for sucrose solution. The impact of such chronic treatment on spontaneous locomotion and spatial memory was also examined. Changes in sucrose tolerance could indicate the potential development of a change in food compulsion or addiction related to the action of pramipexole. Neither the bilateral lesion of the VTA nor chronic treatment with pramipexole altered the spontaneous locomotion or spatial memory in rats. Rats without pramipexole treatment quickly developed a stable intake of sucrose solution in the 12 h access phase. On the contrary, when under daily pramipexole treatment, rats developed a stronger and ongoing escalation of their sucrose solution intakes. In addition, we noted that the change in sucrose consumption was sustained by an increase of the expression of the Dopamine D3 receptor in the core and the shell regions of the nucleus accumbens. The present results may suggest that long-term stimulation of the Dopamine D3 receptor in animals induces a strong increase in sucrose consumption, indicating an effect of this receptor on certain pathological aspects of food eating.

No MeSH data available.


Related in: MedlinePlus