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Measuring hemoglobin levels in the optic disc of Parkinson's disease patients using new colorimetric analysis software.

Bambo MP, Garcia-Martin E, Satue M, Perez-Olivan S, Alayon S, Gonzalez-Hernandez M, Polo V, Larrosa JM, Gonzalez-De la Rosa M - Parkinsons Dis (2014)

Bottom Line: PD patients exhibited significantly reduced mean optic disc Hb percentages (57.56% in PD, 67.63% in healthy subjects; P = 0.001) as well as reduced Hb in almost all analyzed sectors, with the largest differences detected in the inferior and nasal sectors.RNFL parameters were significantly reduced in PD patients compared with healthy subjects, especially in the inferior quadrant.Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Ophthalmology Department, Miguel Servet University Hospital, Consultas Externas de Oftalmologia, C/Padre Arrupe, 50009 Zaragoza, Spain ; Aragones Institute of Health Sciences (IIS Aragon), 50009 Zaragoza, Spain.

ABSTRACT
Objective. To evaluate a new method of measuring hemoglobin (Hb) levels and quantifying the color changes in the optic nerve head of Parkinson's disease (PD) patients. We also compared differences in retinal nerve fiber layer (RNFL) thicknesses obtained using spectral domain optical coherence tomography (OCT) device between PD group and healthy group. Methods. One hundred and fifty-five PD patients and 91 sex- and age-matched healthy subjects were included in this cross-sectional study. OCT examinations and one photograph of the optic disc were performed. The Laguna ONhE ("optic nerve hemoglobin"; Insoft SL, Tenerife, Spain) software was used to analyze the Hb level on the acquired optic disc photographs. Results. PD patients exhibited significantly reduced mean optic disc Hb percentages (57.56% in PD, 67.63% in healthy subjects; P = 0.001) as well as reduced Hb in almost all analyzed sectors, with the largest differences detected in the inferior and nasal sectors. RNFL parameters were significantly reduced in PD patients compared with healthy subjects, especially in the inferior quadrant. Conclusions. Measurements of optic disc Hb levels obtained with the Laguna ONhE software had good ability to detect optic nerve color changes (more papillary paleness and consequently this could suggest optic atrophy and axonal loss) in PD patients.

No MeSH data available.


Related in: MedlinePlus

Examples of papillary images in a healthy subject (left column) and a Parkinson's disease patient (right column). Upper images show the color fundus photographs of the optic discs (the white arrow marks the papilla of a healthy subject, and the black arrow marks the papilla of a Parkinson's disease patient). The main parts of a healthy optic nerve can be distinguished in the upper-left image (white arrow): a small “yellow-white” depression is formed in the center of the papilla, which is referred to as the optic cup, to contrast it with the “orange” surrounding neural tissue that is referred to as the neuroretinal rim. Lower images show the corresponding pseudoimages representing the amount of hemoglobin. The colorimetric scale at the right side of the lower images shows the amount of hemoglobin.
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fig2: Examples of papillary images in a healthy subject (left column) and a Parkinson's disease patient (right column). Upper images show the color fundus photographs of the optic discs (the white arrow marks the papilla of a healthy subject, and the black arrow marks the papilla of a Parkinson's disease patient). The main parts of a healthy optic nerve can be distinguished in the upper-left image (white arrow): a small “yellow-white” depression is formed in the center of the papilla, which is referred to as the optic cup, to contrast it with the “orange” surrounding neural tissue that is referred to as the neuroretinal rim. Lower images show the corresponding pseudoimages representing the amount of hemoglobin. The colorimetric scale at the right side of the lower images shows the amount of hemoglobin.

Mentions: Mean Hb percentage and Hb content in sectors 3, 5, 8, 9, 12, 15, 19, and 21 (which mostly correspond with the outer ring of the papilla) calculated by the Laguna ONhE program were significantly lower in PD patients than in healthy controls (t-test with Bonferroni correction, P < 0.002). The main differences were found in sectors 3, 9, and 12 of the papilla and ranged from 0.77% (in sector 19) to 12.14% (in sector 12) (Table 2). Figure 2 shows, as an example, the morphology of the papilla and the corresponding pseudoimages indicating the Hb levels provided by Laguna ONhE analysis in a healthy control and a patient with PD.


Measuring hemoglobin levels in the optic disc of Parkinson's disease patients using new colorimetric analysis software.

Bambo MP, Garcia-Martin E, Satue M, Perez-Olivan S, Alayon S, Gonzalez-Hernandez M, Polo V, Larrosa JM, Gonzalez-De la Rosa M - Parkinsons Dis (2014)

Examples of papillary images in a healthy subject (left column) and a Parkinson's disease patient (right column). Upper images show the color fundus photographs of the optic discs (the white arrow marks the papilla of a healthy subject, and the black arrow marks the papilla of a Parkinson's disease patient). The main parts of a healthy optic nerve can be distinguished in the upper-left image (white arrow): a small “yellow-white” depression is formed in the center of the papilla, which is referred to as the optic cup, to contrast it with the “orange” surrounding neural tissue that is referred to as the neuroretinal rim. Lower images show the corresponding pseudoimages representing the amount of hemoglobin. The colorimetric scale at the right side of the lower images shows the amount of hemoglobin.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4284935&req=5

fig2: Examples of papillary images in a healthy subject (left column) and a Parkinson's disease patient (right column). Upper images show the color fundus photographs of the optic discs (the white arrow marks the papilla of a healthy subject, and the black arrow marks the papilla of a Parkinson's disease patient). The main parts of a healthy optic nerve can be distinguished in the upper-left image (white arrow): a small “yellow-white” depression is formed in the center of the papilla, which is referred to as the optic cup, to contrast it with the “orange” surrounding neural tissue that is referred to as the neuroretinal rim. Lower images show the corresponding pseudoimages representing the amount of hemoglobin. The colorimetric scale at the right side of the lower images shows the amount of hemoglobin.
Mentions: Mean Hb percentage and Hb content in sectors 3, 5, 8, 9, 12, 15, 19, and 21 (which mostly correspond with the outer ring of the papilla) calculated by the Laguna ONhE program were significantly lower in PD patients than in healthy controls (t-test with Bonferroni correction, P < 0.002). The main differences were found in sectors 3, 9, and 12 of the papilla and ranged from 0.77% (in sector 19) to 12.14% (in sector 12) (Table 2). Figure 2 shows, as an example, the morphology of the papilla and the corresponding pseudoimages indicating the Hb levels provided by Laguna ONhE analysis in a healthy control and a patient with PD.

Bottom Line: PD patients exhibited significantly reduced mean optic disc Hb percentages (57.56% in PD, 67.63% in healthy subjects; P = 0.001) as well as reduced Hb in almost all analyzed sectors, with the largest differences detected in the inferior and nasal sectors.RNFL parameters were significantly reduced in PD patients compared with healthy subjects, especially in the inferior quadrant.Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Ophthalmology Department, Miguel Servet University Hospital, Consultas Externas de Oftalmologia, C/Padre Arrupe, 50009 Zaragoza, Spain ; Aragones Institute of Health Sciences (IIS Aragon), 50009 Zaragoza, Spain.

ABSTRACT
Objective. To evaluate a new method of measuring hemoglobin (Hb) levels and quantifying the color changes in the optic nerve head of Parkinson's disease (PD) patients. We also compared differences in retinal nerve fiber layer (RNFL) thicknesses obtained using spectral domain optical coherence tomography (OCT) device between PD group and healthy group. Methods. One hundred and fifty-five PD patients and 91 sex- and age-matched healthy subjects were included in this cross-sectional study. OCT examinations and one photograph of the optic disc were performed. The Laguna ONhE ("optic nerve hemoglobin"; Insoft SL, Tenerife, Spain) software was used to analyze the Hb level on the acquired optic disc photographs. Results. PD patients exhibited significantly reduced mean optic disc Hb percentages (57.56% in PD, 67.63% in healthy subjects; P = 0.001) as well as reduced Hb in almost all analyzed sectors, with the largest differences detected in the inferior and nasal sectors. RNFL parameters were significantly reduced in PD patients compared with healthy subjects, especially in the inferior quadrant. Conclusions. Measurements of optic disc Hb levels obtained with the Laguna ONhE software had good ability to detect optic nerve color changes (more papillary paleness and consequently this could suggest optic atrophy and axonal loss) in PD patients.

No MeSH data available.


Related in: MedlinePlus