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Genital Schistosomiasis: A Report on Two Cases of Ovarian Carcinomas Containing Viable Eggs of Schistosoma mansoni.

Gonçalves Amorim A, Alves Barbosa Pagio F, Neves Ferreira R, Chambô Filho A - Case Rep Obstet Gynecol (2014)

Bottom Line: Histopathology of the ovary showed a mucinous cystadenocarcinoma of the intestinal type in the first patient and a papillary serous carcinoma in the second, with both tumors containing viable eggs of Schistosoma mansoni.The neoplasms probably serve as a migratory route for the adult parasites and the embolization of eggs.Nevertheless, there is insufficient evidence to confirm the malignization of a benign lesion due to the presence of Schistosoma mansoni.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Santa Casa de Misericórdia Hospital, 143 Dr. João dos Santos Neves, 29025-023 Vitória, ES, Brazil.

ABSTRACT
Schistosomiasis is a parasitic infection that is highly prevalent worldwide, with a variety of species being responsible for causing the disease. In Brazil, however, the only identified species is Schistosoma mansoni. The adult parasites inhabit the blood vessels of the hepatic portal system of the main host. The disease may range from being asymptomatic to provoking liver damage or portal hypertension. Furthermore, ectopic schistosomiasis may develop, and several hypotheses have been raised to explain the occurrence of the disease. This paper describes two cases, one in a 39-year-old woman and the other in a 47-year-old woman. Both had similar symptoms of pain and abdominal distension caused by a large abdominal/pelvic mass. Histopathology of the ovary showed a mucinous cystadenocarcinoma of the intestinal type in the first patient and a papillary serous carcinoma in the second, with both tumors containing viable eggs of Schistosoma mansoni. The neoplasms probably serve as a migratory route for the adult parasites and the embolization of eggs. Nevertheless, there is insufficient evidence to confirm the malignization of a benign lesion due to the presence of Schistosoma mansoni. Few cases have been reported in the international literature on the association between ovarian schistosomiasis and neoplasms.

No MeSH data available.


Related in: MedlinePlus

Case report #1. (a) Macroscopic view of the left ovary measuring 25 × 20 × 8 cm. (b) Viable S. mansoni eggs (hematoxylin-eosin, magnification 40x). (c) Detailed view of a S. mansoni egg (periodic acid-Schiff, magnification 400x).
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fig1: Case report #1. (a) Macroscopic view of the left ovary measuring 25 × 20 × 8 cm. (b) Viable S. mansoni eggs (hematoxylin-eosin, magnification 40x). (c) Detailed view of a S. mansoni egg (periodic acid-Schiff, magnification 400x).

Mentions: Cytology was positive for malignant cells. The uterus had no notable histopathological abnormalities. Macroscopically, the left ovary measured 20 × 20 × 8 cm, with a smooth, shiny surface (Figure 1(a)). Sectioning revealed a cystic lesion with irregular internal walls, friable vegetation, and solid areas of white tissue. Microscopic examination revealed a mucinous cystadenocarcinoma of the intestinal type with solid, cystic, cribriform, and infiltrating areas with foci of necrosis. Numerous viable S. mansoni eggs surrounded by eosinophilic granulomas permeating the neoplastic tissue were found in 2 of the 30 slides examined (Figures 1(b) and 1(c)). Reactive inflammation and the fact that the eggshells were intact indicated that the eggs were viable. There was no fibrosis or calcification.


Genital Schistosomiasis: A Report on Two Cases of Ovarian Carcinomas Containing Viable Eggs of Schistosoma mansoni.

Gonçalves Amorim A, Alves Barbosa Pagio F, Neves Ferreira R, Chambô Filho A - Case Rep Obstet Gynecol (2014)

Case report #1. (a) Macroscopic view of the left ovary measuring 25 × 20 × 8 cm. (b) Viable S. mansoni eggs (hematoxylin-eosin, magnification 40x). (c) Detailed view of a S. mansoni egg (periodic acid-Schiff, magnification 400x).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4283256&req=5

fig1: Case report #1. (a) Macroscopic view of the left ovary measuring 25 × 20 × 8 cm. (b) Viable S. mansoni eggs (hematoxylin-eosin, magnification 40x). (c) Detailed view of a S. mansoni egg (periodic acid-Schiff, magnification 400x).
Mentions: Cytology was positive for malignant cells. The uterus had no notable histopathological abnormalities. Macroscopically, the left ovary measured 20 × 20 × 8 cm, with a smooth, shiny surface (Figure 1(a)). Sectioning revealed a cystic lesion with irregular internal walls, friable vegetation, and solid areas of white tissue. Microscopic examination revealed a mucinous cystadenocarcinoma of the intestinal type with solid, cystic, cribriform, and infiltrating areas with foci of necrosis. Numerous viable S. mansoni eggs surrounded by eosinophilic granulomas permeating the neoplastic tissue were found in 2 of the 30 slides examined (Figures 1(b) and 1(c)). Reactive inflammation and the fact that the eggshells were intact indicated that the eggs were viable. There was no fibrosis or calcification.

Bottom Line: Histopathology of the ovary showed a mucinous cystadenocarcinoma of the intestinal type in the first patient and a papillary serous carcinoma in the second, with both tumors containing viable eggs of Schistosoma mansoni.The neoplasms probably serve as a migratory route for the adult parasites and the embolization of eggs.Nevertheless, there is insufficient evidence to confirm the malignization of a benign lesion due to the presence of Schistosoma mansoni.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Santa Casa de Misericórdia Hospital, 143 Dr. João dos Santos Neves, 29025-023 Vitória, ES, Brazil.

ABSTRACT
Schistosomiasis is a parasitic infection that is highly prevalent worldwide, with a variety of species being responsible for causing the disease. In Brazil, however, the only identified species is Schistosoma mansoni. The adult parasites inhabit the blood vessels of the hepatic portal system of the main host. The disease may range from being asymptomatic to provoking liver damage or portal hypertension. Furthermore, ectopic schistosomiasis may develop, and several hypotheses have been raised to explain the occurrence of the disease. This paper describes two cases, one in a 39-year-old woman and the other in a 47-year-old woman. Both had similar symptoms of pain and abdominal distension caused by a large abdominal/pelvic mass. Histopathology of the ovary showed a mucinous cystadenocarcinoma of the intestinal type in the first patient and a papillary serous carcinoma in the second, with both tumors containing viable eggs of Schistosoma mansoni. The neoplasms probably serve as a migratory route for the adult parasites and the embolization of eggs. Nevertheless, there is insufficient evidence to confirm the malignization of a benign lesion due to the presence of Schistosoma mansoni. Few cases have been reported in the international literature on the association between ovarian schistosomiasis and neoplasms.

No MeSH data available.


Related in: MedlinePlus