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Ciprofloxacin release using natural rubber latex membranes as carrier.

Dias Murbach H, Jaques Ogawa G, Azevedo Borges F, Romeiro Miranda MC, Lopes R, Roberto de Barros N, Guedes Mazalli AV, Gonçalves da Silva R, Ferreira Cinman JL, de Camargo Drago B, Donizetti Herculano R - Int J Biomater (2014)

Bottom Line: CIP was found to be adsorbed on the NRL membrane, according to results of energy dispersive X-ray spectroscopy.Results show that the membrane can release CIP for up to 59.08% in 312 hours and the mechanism is due to super case II (non-Fickian).The kinetics of the drug release could be fitted with double exponential function X-ray diffraction and Fourier transform infrared (FTIR) spectroscopy shows some interaction by hydrogen bound, which influences its mechanical behavior.

View Article: PubMed Central - PubMed

Affiliation: Biological Sciences Department, Faculty of Language & Sciences, São Paulo State University (UNESP), 2100 Dom Antonio Avenue, 19806-900 Assis, SP, Brazil.

ABSTRACT
Natural rubber latex (NRL) from Hevea brasiliensis is easily manipulated, low cost, is of can stimulate natural angiogenesis and cellular adhesion, is a biocompatible, material and presents high mechanical resistance. Ciprofloxacin (CIP) is a synthetic antibiotic (fluoroquinolone) used in the treatment of infection at external fixation screws sites and remote infections, and this use is increasingly frequent in medical practice. The aim of this study was to develop a novel sustained delivery system for CIP based on NRL membranes and to study its delivery system behavior. CIP was found to be adsorbed on the NRL membrane, according to results of energy dispersive X-ray spectroscopy. Results show that the membrane can release CIP for up to 59.08% in 312 hours and the mechanism is due to super case II (non-Fickian). The kinetics of the drug release could be fitted with double exponential function X-ray diffraction and Fourier transform infrared (FTIR) spectroscopy shows some interaction by hydrogen bound, which influences its mechanical behavior.

No MeSH data available.


Related in: MedlinePlus

Representative stress-strain curves NRL and ciprofloxacin loaded NRL.
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fig6: Representative stress-strain curves NRL and ciprofloxacin loaded NRL.

Mentions: The addition of CIP to the NRL membrane had influence on the mechanical behavior of NRL (Figure 6). The new material became stiffer and brittle, with a smaller plastic deformation (less ductile). Table 2 shows that the addition of CIP reduced 1.2 times the elongation at break and reduced the tensile strength.


Ciprofloxacin release using natural rubber latex membranes as carrier.

Dias Murbach H, Jaques Ogawa G, Azevedo Borges F, Romeiro Miranda MC, Lopes R, Roberto de Barros N, Guedes Mazalli AV, Gonçalves da Silva R, Ferreira Cinman JL, de Camargo Drago B, Donizetti Herculano R - Int J Biomater (2014)

Representative stress-strain curves NRL and ciprofloxacin loaded NRL.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4283226&req=5

fig6: Representative stress-strain curves NRL and ciprofloxacin loaded NRL.
Mentions: The addition of CIP to the NRL membrane had influence on the mechanical behavior of NRL (Figure 6). The new material became stiffer and brittle, with a smaller plastic deformation (less ductile). Table 2 shows that the addition of CIP reduced 1.2 times the elongation at break and reduced the tensile strength.

Bottom Line: CIP was found to be adsorbed on the NRL membrane, according to results of energy dispersive X-ray spectroscopy.Results show that the membrane can release CIP for up to 59.08% in 312 hours and the mechanism is due to super case II (non-Fickian).The kinetics of the drug release could be fitted with double exponential function X-ray diffraction and Fourier transform infrared (FTIR) spectroscopy shows some interaction by hydrogen bound, which influences its mechanical behavior.

View Article: PubMed Central - PubMed

Affiliation: Biological Sciences Department, Faculty of Language & Sciences, São Paulo State University (UNESP), 2100 Dom Antonio Avenue, 19806-900 Assis, SP, Brazil.

ABSTRACT
Natural rubber latex (NRL) from Hevea brasiliensis is easily manipulated, low cost, is of can stimulate natural angiogenesis and cellular adhesion, is a biocompatible, material and presents high mechanical resistance. Ciprofloxacin (CIP) is a synthetic antibiotic (fluoroquinolone) used in the treatment of infection at external fixation screws sites and remote infections, and this use is increasingly frequent in medical practice. The aim of this study was to develop a novel sustained delivery system for CIP based on NRL membranes and to study its delivery system behavior. CIP was found to be adsorbed on the NRL membrane, according to results of energy dispersive X-ray spectroscopy. Results show that the membrane can release CIP for up to 59.08% in 312 hours and the mechanism is due to super case II (non-Fickian). The kinetics of the drug release could be fitted with double exponential function X-ray diffraction and Fourier transform infrared (FTIR) spectroscopy shows some interaction by hydrogen bound, which influences its mechanical behavior.

No MeSH data available.


Related in: MedlinePlus