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Ciprofloxacin release using natural rubber latex membranes as carrier.

Dias Murbach H, Jaques Ogawa G, Azevedo Borges F, Romeiro Miranda MC, Lopes R, Roberto de Barros N, Guedes Mazalli AV, Gonçalves da Silva R, Ferreira Cinman JL, de Camargo Drago B, Donizetti Herculano R - Int J Biomater (2014)

Bottom Line: CIP was found to be adsorbed on the NRL membrane, according to results of energy dispersive X-ray spectroscopy.Results show that the membrane can release CIP for up to 59.08% in 312 hours and the mechanism is due to super case II (non-Fickian).The kinetics of the drug release could be fitted with double exponential function X-ray diffraction and Fourier transform infrared (FTIR) spectroscopy shows some interaction by hydrogen bound, which influences its mechanical behavior.

View Article: PubMed Central - PubMed

Affiliation: Biological Sciences Department, Faculty of Language & Sciences, São Paulo State University (UNESP), 2100 Dom Antonio Avenue, 19806-900 Assis, SP, Brazil.

ABSTRACT
Natural rubber latex (NRL) from Hevea brasiliensis is easily manipulated, low cost, is of can stimulate natural angiogenesis and cellular adhesion, is a biocompatible, material and presents high mechanical resistance. Ciprofloxacin (CIP) is a synthetic antibiotic (fluoroquinolone) used in the treatment of infection at external fixation screws sites and remote infections, and this use is increasingly frequent in medical practice. The aim of this study was to develop a novel sustained delivery system for CIP based on NRL membranes and to study its delivery system behavior. CIP was found to be adsorbed on the NRL membrane, according to results of energy dispersive X-ray spectroscopy. Results show that the membrane can release CIP for up to 59.08% in 312 hours and the mechanism is due to super case II (non-Fickian). The kinetics of the drug release could be fitted with double exponential function X-ray diffraction and Fourier transform infrared (FTIR) spectroscopy shows some interaction by hydrogen bound, which influences its mechanical behavior.

No MeSH data available.


Related in: MedlinePlus

Absorbance intensity as a function of ciprofloxacin concentration in solution.
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Related In: Results  -  Collection


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fig1: Absorbance intensity as a function of ciprofloxacin concentration in solution.

Mentions: Pharmaceutical innovation and research are increasingly focusing their attention on the development of delivery systems to enhance desirable therapeutic purposes while minimizing side effects [9, 24]. For the CIP study, the interaction between drug and NRL membrane was evaluated and how it can be incorporated and released from the membrane was also evaluated. Figure 1 shows the absorbance intensity as a function of CIP concentration in solution. This calibration curve is important to establish a pattern between absorbance and the drug concentration. In this experiment, several drug concentrations from 0.005 to 0.05 mg/mL were used and then the absorbance of the different solutions was measured at 275 nm (spectrophotometer LGS53, BEL Photonics). Using the calibration curve, a sample's concentration can be derived by measuring its absorbance and then finding the corresponding y-axis intercept. Note that the graph shows the drug's absorbance range.


Ciprofloxacin release using natural rubber latex membranes as carrier.

Dias Murbach H, Jaques Ogawa G, Azevedo Borges F, Romeiro Miranda MC, Lopes R, Roberto de Barros N, Guedes Mazalli AV, Gonçalves da Silva R, Ferreira Cinman JL, de Camargo Drago B, Donizetti Herculano R - Int J Biomater (2014)

Absorbance intensity as a function of ciprofloxacin concentration in solution.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4283226&req=5

fig1: Absorbance intensity as a function of ciprofloxacin concentration in solution.
Mentions: Pharmaceutical innovation and research are increasingly focusing their attention on the development of delivery systems to enhance desirable therapeutic purposes while minimizing side effects [9, 24]. For the CIP study, the interaction between drug and NRL membrane was evaluated and how it can be incorporated and released from the membrane was also evaluated. Figure 1 shows the absorbance intensity as a function of CIP concentration in solution. This calibration curve is important to establish a pattern between absorbance and the drug concentration. In this experiment, several drug concentrations from 0.005 to 0.05 mg/mL were used and then the absorbance of the different solutions was measured at 275 nm (spectrophotometer LGS53, BEL Photonics). Using the calibration curve, a sample's concentration can be derived by measuring its absorbance and then finding the corresponding y-axis intercept. Note that the graph shows the drug's absorbance range.

Bottom Line: CIP was found to be adsorbed on the NRL membrane, according to results of energy dispersive X-ray spectroscopy.Results show that the membrane can release CIP for up to 59.08% in 312 hours and the mechanism is due to super case II (non-Fickian).The kinetics of the drug release could be fitted with double exponential function X-ray diffraction and Fourier transform infrared (FTIR) spectroscopy shows some interaction by hydrogen bound, which influences its mechanical behavior.

View Article: PubMed Central - PubMed

Affiliation: Biological Sciences Department, Faculty of Language & Sciences, São Paulo State University (UNESP), 2100 Dom Antonio Avenue, 19806-900 Assis, SP, Brazil.

ABSTRACT
Natural rubber latex (NRL) from Hevea brasiliensis is easily manipulated, low cost, is of can stimulate natural angiogenesis and cellular adhesion, is a biocompatible, material and presents high mechanical resistance. Ciprofloxacin (CIP) is a synthetic antibiotic (fluoroquinolone) used in the treatment of infection at external fixation screws sites and remote infections, and this use is increasingly frequent in medical practice. The aim of this study was to develop a novel sustained delivery system for CIP based on NRL membranes and to study its delivery system behavior. CIP was found to be adsorbed on the NRL membrane, according to results of energy dispersive X-ray spectroscopy. Results show that the membrane can release CIP for up to 59.08% in 312 hours and the mechanism is due to super case II (non-Fickian). The kinetics of the drug release could be fitted with double exponential function X-ray diffraction and Fourier transform infrared (FTIR) spectroscopy shows some interaction by hydrogen bound, which influences its mechanical behavior.

No MeSH data available.


Related in: MedlinePlus