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Test-retest reproducibility of cannabinoid-receptor type 1 availability quantified with the PET ligand [¹¹C]MePPEP.

Riaño Barros DA, McGinnity CJ, Rosso L, Heckemann RA, Howes OD, Brooks DJ, Duncan JS, Turkheimer FE, Koepp MJ, Hammers A - Neuroimage (2014)

Bottom Line: The highest pallidum:pons ratios of binding estimates were achieved by mSUV (4.2), spectral analysis-derived parametric maps (3.6), and 2kbv (3.6).Quantification of CB1 receptor availability using [(11)C]MePPEP shows good to excellent reproducibility with several kinetic models and model-free analyses, whether applied on a region-of-interest or voxelwise basis.Simple mSUV measures were also reliable for most regions, but do not allow fully quantitative interpretation. [(11)C]MePPEP PET is well placed as a tool to investigate CB1-receptor mediated neurotransmission in health and disease.

View Article: PubMed Central - PubMed

Affiliation: Centre for Neuroscience, Department of Medicine, Imperial College London, London, UK; MRC Clinical Sciences Centre Hammersmith Hospital, London, UK.

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Related in: MedlinePlus

Average time activity curves for the pallidum (top) and pons (bottom): the average uptake in each region as a function of time in minutes, subsequently fitted with a two-compartment (2kbv) model.
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f0020: Average time activity curves for the pallidum (top) and pons (bottom): the average uptake in each region as a function of time in minutes, subsequently fitted with a two-compartment (2kbv) model.

Mentions: Global intensities of summed radioactivity images did not differ between test and retest studies (median, interquartile 25th–75th: test: 1.2, 1.0–1.6; retest: 1.3, 1.1–1.5; p > 0.6). Fig. 3 shows examples of time–activity curves.


Test-retest reproducibility of cannabinoid-receptor type 1 availability quantified with the PET ligand [¹¹C]MePPEP.

Riaño Barros DA, McGinnity CJ, Rosso L, Heckemann RA, Howes OD, Brooks DJ, Duncan JS, Turkheimer FE, Koepp MJ, Hammers A - Neuroimage (2014)

Average time activity curves for the pallidum (top) and pons (bottom): the average uptake in each region as a function of time in minutes, subsequently fitted with a two-compartment (2kbv) model.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4283194&req=5

f0020: Average time activity curves for the pallidum (top) and pons (bottom): the average uptake in each region as a function of time in minutes, subsequently fitted with a two-compartment (2kbv) model.
Mentions: Global intensities of summed radioactivity images did not differ between test and retest studies (median, interquartile 25th–75th: test: 1.2, 1.0–1.6; retest: 1.3, 1.1–1.5; p > 0.6). Fig. 3 shows examples of time–activity curves.

Bottom Line: The highest pallidum:pons ratios of binding estimates were achieved by mSUV (4.2), spectral analysis-derived parametric maps (3.6), and 2kbv (3.6).Quantification of CB1 receptor availability using [(11)C]MePPEP shows good to excellent reproducibility with several kinetic models and model-free analyses, whether applied on a region-of-interest or voxelwise basis.Simple mSUV measures were also reliable for most regions, but do not allow fully quantitative interpretation. [(11)C]MePPEP PET is well placed as a tool to investigate CB1-receptor mediated neurotransmission in health and disease.

View Article: PubMed Central - PubMed

Affiliation: Centre for Neuroscience, Department of Medicine, Imperial College London, London, UK; MRC Clinical Sciences Centre Hammersmith Hospital, London, UK.

Show MeSH
Related in: MedlinePlus