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Test-retest reproducibility of cannabinoid-receptor type 1 availability quantified with the PET ligand [¹¹C]MePPEP.

Riaño Barros DA, McGinnity CJ, Rosso L, Heckemann RA, Howes OD, Brooks DJ, Duncan JS, Turkheimer FE, Koepp MJ, Hammers A - Neuroimage (2014)

Bottom Line: The highest pallidum:pons ratios of binding estimates were achieved by mSUV (4.2), spectral analysis-derived parametric maps (3.6), and 2kbv (3.6).Quantification of CB1 receptor availability using [(11)C]MePPEP shows good to excellent reproducibility with several kinetic models and model-free analyses, whether applied on a region-of-interest or voxelwise basis.Simple mSUV measures were also reliable for most regions, but do not allow fully quantitative interpretation. [(11)C]MePPEP PET is well placed as a tool to investigate CB1-receptor mediated neurotransmission in health and disease.

View Article: PubMed Central - PubMed

Affiliation: Centre for Neuroscience, Department of Medicine, Imperial College London, London, UK; MRC Clinical Sciences Centre Hammersmith Hospital, London, UK.

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Manual delineation of the pons on MRI. (a) Sagittal view, (b) coronal view, A — Anterior, R — right. The pons was first delineated on sagittal views, followed by coronal and axial views, with the following limits; anterior/ventral: cisterna interpeduncularis and basilar artery (1); posterior/dorsal: floor of the fourth ventricle (2); superior: a line was drawn from the floor of the fourth ventricle below the superior cerebellar peduncle (3) along the lower limit of the cerebral peduncle, to the indentation between the pons and the midbrain (4); inferior: a line was drawn from the floor of the fourth ventricle above the inferior peduncle (6) to the upper limits of the olive and pyramid of the medulla oblongata (7), i.e. to the indentation between the pons and medulla oblongata (8); on coronal view: following anatomical boundaries of pons, which are clearly visible; on axial view: following delineation in both sagittal and coronal views, the pons is now clearly delineated, and the axial view is used for verification. [5 — posterior cerebral artery].
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f0010: Manual delineation of the pons on MRI. (a) Sagittal view, (b) coronal view, A — Anterior, R — right. The pons was first delineated on sagittal views, followed by coronal and axial views, with the following limits; anterior/ventral: cisterna interpeduncularis and basilar artery (1); posterior/dorsal: floor of the fourth ventricle (2); superior: a line was drawn from the floor of the fourth ventricle below the superior cerebellar peduncle (3) along the lower limit of the cerebral peduncle, to the indentation between the pons and the midbrain (4); inferior: a line was drawn from the floor of the fourth ventricle above the inferior peduncle (6) to the upper limits of the olive and pyramid of the medulla oblongata (7), i.e. to the indentation between the pons and medulla oblongata (8); on coronal view: following anatomical boundaries of pons, which are clearly visible; on axial view: following delineation in both sagittal and coronal views, the pons is now clearly delineated, and the axial view is used for verification. [5 — posterior cerebral artery].

Mentions: Because the pons is not included in the 83 regions obtained via MAPER, we delineated it manually using Analyze 8.1 (Fig. 1).


Test-retest reproducibility of cannabinoid-receptor type 1 availability quantified with the PET ligand [¹¹C]MePPEP.

Riaño Barros DA, McGinnity CJ, Rosso L, Heckemann RA, Howes OD, Brooks DJ, Duncan JS, Turkheimer FE, Koepp MJ, Hammers A - Neuroimage (2014)

Manual delineation of the pons on MRI. (a) Sagittal view, (b) coronal view, A — Anterior, R — right. The pons was first delineated on sagittal views, followed by coronal and axial views, with the following limits; anterior/ventral: cisterna interpeduncularis and basilar artery (1); posterior/dorsal: floor of the fourth ventricle (2); superior: a line was drawn from the floor of the fourth ventricle below the superior cerebellar peduncle (3) along the lower limit of the cerebral peduncle, to the indentation between the pons and the midbrain (4); inferior: a line was drawn from the floor of the fourth ventricle above the inferior peduncle (6) to the upper limits of the olive and pyramid of the medulla oblongata (7), i.e. to the indentation between the pons and medulla oblongata (8); on coronal view: following anatomical boundaries of pons, which are clearly visible; on axial view: following delineation in both sagittal and coronal views, the pons is now clearly delineated, and the axial view is used for verification. [5 — posterior cerebral artery].
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4283194&req=5

f0010: Manual delineation of the pons on MRI. (a) Sagittal view, (b) coronal view, A — Anterior, R — right. The pons was first delineated on sagittal views, followed by coronal and axial views, with the following limits; anterior/ventral: cisterna interpeduncularis and basilar artery (1); posterior/dorsal: floor of the fourth ventricle (2); superior: a line was drawn from the floor of the fourth ventricle below the superior cerebellar peduncle (3) along the lower limit of the cerebral peduncle, to the indentation between the pons and the midbrain (4); inferior: a line was drawn from the floor of the fourth ventricle above the inferior peduncle (6) to the upper limits of the olive and pyramid of the medulla oblongata (7), i.e. to the indentation between the pons and medulla oblongata (8); on coronal view: following anatomical boundaries of pons, which are clearly visible; on axial view: following delineation in both sagittal and coronal views, the pons is now clearly delineated, and the axial view is used for verification. [5 — posterior cerebral artery].
Mentions: Because the pons is not included in the 83 regions obtained via MAPER, we delineated it manually using Analyze 8.1 (Fig. 1).

Bottom Line: The highest pallidum:pons ratios of binding estimates were achieved by mSUV (4.2), spectral analysis-derived parametric maps (3.6), and 2kbv (3.6).Quantification of CB1 receptor availability using [(11)C]MePPEP shows good to excellent reproducibility with several kinetic models and model-free analyses, whether applied on a region-of-interest or voxelwise basis.Simple mSUV measures were also reliable for most regions, but do not allow fully quantitative interpretation. [(11)C]MePPEP PET is well placed as a tool to investigate CB1-receptor mediated neurotransmission in health and disease.

View Article: PubMed Central - PubMed

Affiliation: Centre for Neuroscience, Department of Medicine, Imperial College London, London, UK; MRC Clinical Sciences Centre Hammersmith Hospital, London, UK.

Show MeSH
Related in: MedlinePlus