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Differentiation and interaction of tibial versus spinal nerve stimulation for micturition control in the rat.

Su X, Nickles A, Nelson DE - Neurourol. Urodyn. (2013)

Bottom Line: In anesthetized female rats, a wire electrode was placed under either one or both of the TN or L6 SN.A cannula was placed into the bladder via the urethra.Compared to SN neuromodulation, TN neuromodulation is less efficacious.

View Article: PubMed Central - PubMed

Affiliation: Medtronic, Inc., Neuromodulation Research, Minneapolis, Minnesota.

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Related in: MedlinePlus

Effects of bladder inhibitory response to repeated 5-min stimulations (10 Hz, pulse width 0.1 msec). A, B: Typical experimental records showing the bladder rhythmic contraction (mmHg) to two 5 min tibial nerve (TN) stimulations at three times motor threshold intensity (10 Hz, pulse width 0.1 msec). Horizontal bars indicate 5 min duration of nerve stimulation. The contraction traces in (A) illustrate that with an interval of 10 min or less between TN stimulations, the response to a second stimulation was completely blunted; with 15 min between stimulations, the first and second stimulations were equieffective (B). C: Inhibition of the bladder rhythmic contraction to first and second TN stimulation at three times motor threshold intensity and spinal nerve (SN) at motor threshold intensity with increasing interval between stimulations (X-axis). The number of animals is indicated in each symbol. *, P < 0.05, first 5-min stimulation versus second 5-min stimulation, paired Student's t-test.
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fig04: Effects of bladder inhibitory response to repeated 5-min stimulations (10 Hz, pulse width 0.1 msec). A, B: Typical experimental records showing the bladder rhythmic contraction (mmHg) to two 5 min tibial nerve (TN) stimulations at three times motor threshold intensity (10 Hz, pulse width 0.1 msec). Horizontal bars indicate 5 min duration of nerve stimulation. The contraction traces in (A) illustrate that with an interval of 10 min or less between TN stimulations, the response to a second stimulation was completely blunted; with 15 min between stimulations, the first and second stimulations were equieffective (B). C: Inhibition of the bladder rhythmic contraction to first and second TN stimulation at three times motor threshold intensity and spinal nerve (SN) at motor threshold intensity with increasing interval between stimulations (X-axis). The number of animals is indicated in each symbol. *, P < 0.05, first 5-min stimulation versus second 5-min stimulation, paired Student's t-test.

Mentions: A comparison of the bladder inhibitory response to TN and SN stimulation shows that with either of continuous (15 min) or repeated 5 min stimulation, there is a clear difference between the responses to stimulation at the two sites. With only a 5-min interval between two 5 min stimulations, the second SN stimulation (Tmot intensity, bilateral) produced a response (38.33 ± 22% control) equal to the first (46.56 ± 27% control, n = 4, P > 0.05, paired Student's t-test). In contrast, the second tibial stimulation (three times Tmot intensity) produced no inhibition (105.98 ± 12% control, n = 16, combined data from 9 bilateral with 7 unilateral stimulations) while the first stimulation reduced bladder contraction to 65.44 ± 11% control (P < 0.05, paired Student's t-test, Fig. 4C).


Differentiation and interaction of tibial versus spinal nerve stimulation for micturition control in the rat.

Su X, Nickles A, Nelson DE - Neurourol. Urodyn. (2013)

Effects of bladder inhibitory response to repeated 5-min stimulations (10 Hz, pulse width 0.1 msec). A, B: Typical experimental records showing the bladder rhythmic contraction (mmHg) to two 5 min tibial nerve (TN) stimulations at three times motor threshold intensity (10 Hz, pulse width 0.1 msec). Horizontal bars indicate 5 min duration of nerve stimulation. The contraction traces in (A) illustrate that with an interval of 10 min or less between TN stimulations, the response to a second stimulation was completely blunted; with 15 min between stimulations, the first and second stimulations were equieffective (B). C: Inhibition of the bladder rhythmic contraction to first and second TN stimulation at three times motor threshold intensity and spinal nerve (SN) at motor threshold intensity with increasing interval between stimulations (X-axis). The number of animals is indicated in each symbol. *, P < 0.05, first 5-min stimulation versus second 5-min stimulation, paired Student's t-test.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4282097&req=5

fig04: Effects of bladder inhibitory response to repeated 5-min stimulations (10 Hz, pulse width 0.1 msec). A, B: Typical experimental records showing the bladder rhythmic contraction (mmHg) to two 5 min tibial nerve (TN) stimulations at three times motor threshold intensity (10 Hz, pulse width 0.1 msec). Horizontal bars indicate 5 min duration of nerve stimulation. The contraction traces in (A) illustrate that with an interval of 10 min or less between TN stimulations, the response to a second stimulation was completely blunted; with 15 min between stimulations, the first and second stimulations were equieffective (B). C: Inhibition of the bladder rhythmic contraction to first and second TN stimulation at three times motor threshold intensity and spinal nerve (SN) at motor threshold intensity with increasing interval between stimulations (X-axis). The number of animals is indicated in each symbol. *, P < 0.05, first 5-min stimulation versus second 5-min stimulation, paired Student's t-test.
Mentions: A comparison of the bladder inhibitory response to TN and SN stimulation shows that with either of continuous (15 min) or repeated 5 min stimulation, there is a clear difference between the responses to stimulation at the two sites. With only a 5-min interval between two 5 min stimulations, the second SN stimulation (Tmot intensity, bilateral) produced a response (38.33 ± 22% control) equal to the first (46.56 ± 27% control, n = 4, P > 0.05, paired Student's t-test). In contrast, the second tibial stimulation (three times Tmot intensity) produced no inhibition (105.98 ± 12% control, n = 16, combined data from 9 bilateral with 7 unilateral stimulations) while the first stimulation reduced bladder contraction to 65.44 ± 11% control (P < 0.05, paired Student's t-test, Fig. 4C).

Bottom Line: In anesthetized female rats, a wire electrode was placed under either one or both of the TN or L6 SN.A cannula was placed into the bladder via the urethra.Compared to SN neuromodulation, TN neuromodulation is less efficacious.

View Article: PubMed Central - PubMed

Affiliation: Medtronic, Inc., Neuromodulation Research, Minneapolis, Minnesota.

Show MeSH
Related in: MedlinePlus