Differentiation and interaction of tibial versus spinal nerve stimulation for micturition control in the rat.
Bottom Line: In anesthetized female rats, a wire electrode was placed under either one or both of the TN or L6 SN.A cannula was placed into the bladder via the urethra.Compared to SN neuromodulation, TN neuromodulation is less efficacious.
Affiliation: Medtronic, Inc., Neuromodulation Research, Minneapolis, Minnesota.Show MeSH
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Mentions: A comparison of the bladder inhibitory response to TN and SN stimulation shows that with either of continuous (15 min) or repeated 5 min stimulation, there is a clear difference between the responses to stimulation at the two sites. With only a 5-min interval between two 5 min stimulations, the second SN stimulation (Tmot intensity, bilateral) produced a response (38.33 ± 22% control) equal to the first (46.56 ± 27% control, n = 4, P > 0.05, paired Student's t-test). In contrast, the second tibial stimulation (three times Tmot intensity) produced no inhibition (105.98 ± 12% control, n = 16, combined data from 9 bilateral with 7 unilateral stimulations) while the first stimulation reduced bladder contraction to 65.44 ± 11% control (P < 0.05, paired Student's t-test, Fig. 4C).
Affiliation: Medtronic, Inc., Neuromodulation Research, Minneapolis, Minnesota.