Recognition of Salmonella by Dectin-1 induces presentation of peptide antigen to type B T cells.
Bottom Line: The effect could be mimicked by purified PAMPs, the most potent of which were curdlan and zymosan, β-(1,3)-glucan-containing polymers that are recognized by Dectin-1.Type B T cells have been shown to escape thymic tolerance and to transfer pathology in an autoimmune disease model.The induction of type B responses by gram-negative bacteria provides a mechanism by which autoreactive T cells may be produced during infection.
Affiliation: Division of Immunology, Department of Pathology, University of Cambridge, Cambridge, UK.Show MeSH
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Mentions: Finally, we investigated whether our observations were specific to S. Typhimurium or if exposure to other bacteria also resulted in altered presentation to type B T cells. BMDCs were exposed to yeast and a range of gram-positive and gram-negative bacteria, and presentation to type B T cells was examined. In order of potency, gram-negative bacteria induced the largest response, with S. Typhimurium being most effective followed by Escherichia coli, Pseudomonas aeruginosa, and Neisseria pharyngis. The yeast Candida albicans and Corynebacterium diphtheriae also enhanced presentation but to a lesser degree. Finally, the pyogenic gram-positive bacteria Staphylococcus aureus and Staphylococcus epidermidis had only a minor influence on presentation to type B T cells (Fig.5).
Affiliation: Division of Immunology, Department of Pathology, University of Cambridge, Cambridge, UK.