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Elevations in vascular markers and eosinophils in chronic spontaneous urticarial weals with low-level persistence in uninvolved skin.

Kay AB, Ying S, Ardelean E, Mlynek A, Kita H, Clark P, Maurer M - Br. J. Dermatol. (2014)

Bottom Line: Lesional skin in CSU contained significantly more CD31+ endothelial cells; CD31+ blood vessels, neutrophils, eosinophils, basophils and macrophages; and CD3+ T cells than nonlesional skin.Uninvolved skin from CSU contained significantly more CD31+ endothelial cells, CD31+ blood vessels and eosinophils compared with the control subjects.Eosinophils and microvascular changes persist in uninvolved skin, which, together with increased mast cells, suggests that nonlesional skin is primed for further wealing.

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Affiliation: Leukocyte Biology Section, National Heart and Lung Institute, Imperial College, London, SW7 2AZ, U.K.

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(a) The number of tryptase-positive mast cells in lesional and nonlesional skin compared with controls; statistics were performed as in Fig.1. (b–d) Photomicrographs of antitryptase staining in control (b), nonlesional (c) and lesional (d) skin; original magnification ×400.
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fig05: (a) The number of tryptase-positive mast cells in lesional and nonlesional skin compared with controls; statistics were performed as in Fig.1. (b–d) Photomicrographs of antitryptase staining in control (b), nonlesional (c) and lesional (d) skin; original magnification ×400.

Mentions: There was an approximate threefold increase in the numbers of mast cells in nonlesional compared with control skin (P = 0·0006) (Fig.5a). Photomicrographic examples of skin mast cells are shown in Figure5b–d. There was also a significant increase in the numbers of MBP+ eosinophils (P = 0·02), but not neutrophils, basophils, T cells or macrophages, in nonlesional CSU skin compared with controls (Fig.1, and data not shown). In addition CD31+ endothelial cells and CD31+ blood vessels were significantly elevated (P = 0·004 and P = 0·007, respectively) when uninvolved skin was compared with controls (Fig.3).


Elevations in vascular markers and eosinophils in chronic spontaneous urticarial weals with low-level persistence in uninvolved skin.

Kay AB, Ying S, Ardelean E, Mlynek A, Kita H, Clark P, Maurer M - Br. J. Dermatol. (2014)

(a) The number of tryptase-positive mast cells in lesional and nonlesional skin compared with controls; statistics were performed as in Fig.1. (b–d) Photomicrographs of antitryptase staining in control (b), nonlesional (c) and lesional (d) skin; original magnification ×400.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4282040&req=5

fig05: (a) The number of tryptase-positive mast cells in lesional and nonlesional skin compared with controls; statistics were performed as in Fig.1. (b–d) Photomicrographs of antitryptase staining in control (b), nonlesional (c) and lesional (d) skin; original magnification ×400.
Mentions: There was an approximate threefold increase in the numbers of mast cells in nonlesional compared with control skin (P = 0·0006) (Fig.5a). Photomicrographic examples of skin mast cells are shown in Figure5b–d. There was also a significant increase in the numbers of MBP+ eosinophils (P = 0·02), but not neutrophils, basophils, T cells or macrophages, in nonlesional CSU skin compared with controls (Fig.1, and data not shown). In addition CD31+ endothelial cells and CD31+ blood vessels were significantly elevated (P = 0·004 and P = 0·007, respectively) when uninvolved skin was compared with controls (Fig.3).

Bottom Line: Lesional skin in CSU contained significantly more CD31+ endothelial cells; CD31+ blood vessels, neutrophils, eosinophils, basophils and macrophages; and CD3+ T cells than nonlesional skin.Uninvolved skin from CSU contained significantly more CD31+ endothelial cells, CD31+ blood vessels and eosinophils compared with the control subjects.Eosinophils and microvascular changes persist in uninvolved skin, which, together with increased mast cells, suggests that nonlesional skin is primed for further wealing.

View Article: PubMed Central - PubMed

Affiliation: Leukocyte Biology Section, National Heart and Lung Institute, Imperial College, London, SW7 2AZ, U.K.

Show MeSH
Related in: MedlinePlus