Elevations in vascular markers and eosinophils in chronic spontaneous urticarial weals with low-level persistence in uninvolved skin.
Bottom Line: Lesional skin in CSU contained significantly more CD31+ endothelial cells; CD31+ blood vessels, neutrophils, eosinophils, basophils and macrophages; and CD3+ T cells than nonlesional skin.Increased vascularity was confirmed by confocal imaging using the lectin UEA-1.Uninvolved skin from CSU contained significantly more CD31+ endothelial cells, CD31+ blood vessels and eosinophils compared with the control subjects.
Affiliation: Leukocyte Biology Section, National Heart and Lung Institute, Imperial College, London, SW7 2AZ, U.K.Show MeSH
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Mentions: There was an approximate threefold increase in the numbers of mast cells in nonlesional compared with control skin (P = 0·0006) (Fig.5a). Photomicrographic examples of skin mast cells are shown in Figure5b–d. There was also a significant increase in the numbers of MBP+ eosinophils (P = 0·02), but not neutrophils, basophils, T cells or macrophages, in nonlesional CSU skin compared with controls (Fig.1, and data not shown). In addition CD31+ endothelial cells and CD31+ blood vessels were significantly elevated (P = 0·004 and P = 0·007, respectively) when uninvolved skin was compared with controls (Fig.3).
Affiliation: Leukocyte Biology Section, National Heart and Lung Institute, Imperial College, London, SW7 2AZ, U.K.