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Incidence of herpes simplex virus type 2 infections in Africa: a systematic review.

Rajagopal S, Magaret A, Mugo N, Wald A - Open Forum Infect Dis (2014)

Bottom Line: Among women, incidence rates appeared to be higher in those with high-risk sexual behavior, with rates ranging from 3 to 23 per 100 person-years.In contrast, incidence rates in men appeared to be lower, ranging from 1 to 12 per 100 person-years.Among men, condom use and circumcision had a protective effect, whereas prevalent HIV increased the risk of HSV-2 acquisition.

View Article: PubMed Central - PubMed

Affiliation: Departments of Epidemiology.

ABSTRACT
The burden of HSV type 2 varies substantially by region, with the highest incidence and prevalence in sub-Saharan Africa. We undertook a systematic review to identify studies reporting prospective data on incidence rates in men and women in Africa. Of 18 eligible studies, 7 were conducted in high-risk populations. Among women, incidence rates appeared to be higher in those with high-risk sexual behavior, with rates ranging from 3 to 23 per 100 person-years. In contrast, incidence rates in men appeared to be lower, ranging from 1 to 12 per 100 person-years. Risk factors for HSV-2 in women included prevalent human immunodeficiency virus (HIV) infection, younger age at sexual initiation, and sexual activity. Among men, condom use and circumcision had a protective effect, whereas prevalent HIV increased the risk of HSV-2 acquisition. This review draws attention to the high HSV-2 acquisition rates reported in Africa, thereby identifying an efficient setting for preventative HSV-2 vaccine trials.

No MeSH data available.


Related in: MedlinePlus

Incidence rates of herpes simplex virus (HSV)-2 reported in men and women among studies eligible for the systematic review. The area of the circle is proportional to the person-years accrued in a given study.
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OFU043F2: Incidence rates of herpes simplex virus (HSV)-2 reported in men and women among studies eligible for the systematic review. The area of the circle is proportional to the person-years accrued in a given study.

Mentions: In comparison with high-risk cohorts, the baseline prevalence in general populations appeared to be lower, ranging from 6% to 57% with a median of 27%. In addition, incidence appeared to be lower among studies that recruited men from the general population compared with women. Among men, the reported rates ranged from 2 to 12 per 100 person-years with a median of 5 compared with 3 to 21 per 100 person-years with a median of 8 per 100 person-years in women (Figure 2).Figure 1.


Incidence of herpes simplex virus type 2 infections in Africa: a systematic review.

Rajagopal S, Magaret A, Mugo N, Wald A - Open Forum Infect Dis (2014)

Incidence rates of herpes simplex virus (HSV)-2 reported in men and women among studies eligible for the systematic review. The area of the circle is proportional to the person-years accrued in a given study.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4281803&req=5

OFU043F2: Incidence rates of herpes simplex virus (HSV)-2 reported in men and women among studies eligible for the systematic review. The area of the circle is proportional to the person-years accrued in a given study.
Mentions: In comparison with high-risk cohorts, the baseline prevalence in general populations appeared to be lower, ranging from 6% to 57% with a median of 27%. In addition, incidence appeared to be lower among studies that recruited men from the general population compared with women. Among men, the reported rates ranged from 2 to 12 per 100 person-years with a median of 5 compared with 3 to 21 per 100 person-years with a median of 8 per 100 person-years in women (Figure 2).Figure 1.

Bottom Line: Among women, incidence rates appeared to be higher in those with high-risk sexual behavior, with rates ranging from 3 to 23 per 100 person-years.In contrast, incidence rates in men appeared to be lower, ranging from 1 to 12 per 100 person-years.Among men, condom use and circumcision had a protective effect, whereas prevalent HIV increased the risk of HSV-2 acquisition.

View Article: PubMed Central - PubMed

Affiliation: Departments of Epidemiology.

ABSTRACT
The burden of HSV type 2 varies substantially by region, with the highest incidence and prevalence in sub-Saharan Africa. We undertook a systematic review to identify studies reporting prospective data on incidence rates in men and women in Africa. Of 18 eligible studies, 7 were conducted in high-risk populations. Among women, incidence rates appeared to be higher in those with high-risk sexual behavior, with rates ranging from 3 to 23 per 100 person-years. In contrast, incidence rates in men appeared to be lower, ranging from 1 to 12 per 100 person-years. Risk factors for HSV-2 in women included prevalent human immunodeficiency virus (HIV) infection, younger age at sexual initiation, and sexual activity. Among men, condom use and circumcision had a protective effect, whereas prevalent HIV increased the risk of HSV-2 acquisition. This review draws attention to the high HSV-2 acquisition rates reported in Africa, thereby identifying an efficient setting for preventative HSV-2 vaccine trials.

No MeSH data available.


Related in: MedlinePlus