Limits...
Antihematotoxic Role of Bunium persicum Seed Differential Extracts in Animal Model: Reactive Oxygen Species Might Be a Contributor.

Ali T, Saeed K, Abdullah M, Murtaza I - Osong Public Health Res Perspect (2014)

Bottom Line: Bunium persicum is a rich source of oils with different biological activities such as antioxidative and antimicrobial activities.We measured the concentration of free radical [reactive oxygen species (ROS)] and hematological parameters as blast cells from the tibia and femur in different groups.Moreover, there was an imbalance in hematological parameters in untreated and treated groups with a correlation between free radicals and plant extract administration.

View Article: PubMed Central - PubMed

Affiliation: Signal Transduction Laboratory, Department of Biochemistry, Quaid-i-Azam University, Islamabad, Pakistan.

ABSTRACT

Objectives: Humans have been using plants as natural medicines since prehistoric times. Bunium persicum is a rich source of oils with different biological activities such as antioxidative and antimicrobial activities. The aim of this study is to evaluate the antihematotoxic and antioxidative effects of the differential extracts of B. persicum against leukemic blood induced hematotoxicity in an animal model.

Methods: This study was performed on animals, which were divided into several groups: normal control, disease control, and groups that were administered with differential extracts of plants. We measured the concentration of free radical [reactive oxygen species (ROS)] and hematological parameters as blast cells from the tibia and femur in different groups.

Results: The ROS level and blast cells count were higher in disease control groups than in groups treated with varying amounts of B. persicum extract and the normal group. Moreover, there was an imbalance in hematological parameters in untreated and treated groups with a correlation between free radicals and plant extract administration.

Conclusion: These findings may indicate a possible link between free radicals and hematotoxicity and blast cells, while depicting a potential therapeutic role for B. persicum against ROS-induced hematotoxicity.

No MeSH data available.


Related in: MedlinePlus

Bone marrow smear stained with Giemsa stain. The blast cells are indicated by an arrow in each figure. (A) Control disease. (B) normal. (C) Blast cell in EFT. (D) Blast cells in BFT. BFT = .
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4281623&req=5

fig2: Bone marrow smear stained with Giemsa stain. The blast cells are indicated by an arrow in each figure. (A) Control disease. (B) normal. (C) Blast cell in EFT. (D) Blast cells in BFT. BFT = .

Mentions: Large numbers of blast cells were observed in the disease control group as compared with the normal control group. The number of blast cells seen in EFT and BFT was lower compared with that of the disease control group but higher than that of the normal control group (Figure 2).


Antihematotoxic Role of Bunium persicum Seed Differential Extracts in Animal Model: Reactive Oxygen Species Might Be a Contributor.

Ali T, Saeed K, Abdullah M, Murtaza I - Osong Public Health Res Perspect (2014)

Bone marrow smear stained with Giemsa stain. The blast cells are indicated by an arrow in each figure. (A) Control disease. (B) normal. (C) Blast cell in EFT. (D) Blast cells in BFT. BFT = .
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4281623&req=5

fig2: Bone marrow smear stained with Giemsa stain. The blast cells are indicated by an arrow in each figure. (A) Control disease. (B) normal. (C) Blast cell in EFT. (D) Blast cells in BFT. BFT = .
Mentions: Large numbers of blast cells were observed in the disease control group as compared with the normal control group. The number of blast cells seen in EFT and BFT was lower compared with that of the disease control group but higher than that of the normal control group (Figure 2).

Bottom Line: Bunium persicum is a rich source of oils with different biological activities such as antioxidative and antimicrobial activities.We measured the concentration of free radical [reactive oxygen species (ROS)] and hematological parameters as blast cells from the tibia and femur in different groups.Moreover, there was an imbalance in hematological parameters in untreated and treated groups with a correlation between free radicals and plant extract administration.

View Article: PubMed Central - PubMed

Affiliation: Signal Transduction Laboratory, Department of Biochemistry, Quaid-i-Azam University, Islamabad, Pakistan.

ABSTRACT

Objectives: Humans have been using plants as natural medicines since prehistoric times. Bunium persicum is a rich source of oils with different biological activities such as antioxidative and antimicrobial activities. The aim of this study is to evaluate the antihematotoxic and antioxidative effects of the differential extracts of B. persicum against leukemic blood induced hematotoxicity in an animal model.

Methods: This study was performed on animals, which were divided into several groups: normal control, disease control, and groups that were administered with differential extracts of plants. We measured the concentration of free radical [reactive oxygen species (ROS)] and hematological parameters as blast cells from the tibia and femur in different groups.

Results: The ROS level and blast cells count were higher in disease control groups than in groups treated with varying amounts of B. persicum extract and the normal group. Moreover, there was an imbalance in hematological parameters in untreated and treated groups with a correlation between free radicals and plant extract administration.

Conclusion: These findings may indicate a possible link between free radicals and hematotoxicity and blast cells, while depicting a potential therapeutic role for B. persicum against ROS-induced hematotoxicity.

No MeSH data available.


Related in: MedlinePlus