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Malignant pediatric gliosarcoma defies general survival data.

Martin J, Devadoss P, Kannan K, Kumar Sundarraj S - Case Rep Med (2014)

Bottom Line: Gliosarcoma, a variant of glioblastoma multiforme, is a dimorphic tumor known for its intra-axial occurrence and poor survival of less than a year.Here is an 11-year-old boy with gliosarcoma.He has lived through the disease for over 34 months with a residual disease.This case report is to report an unusual long survival of gliosarcoma in a teenager (Ravisankar et al., 2012).

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Oncology, Madras Medical College, Chennai, India.

ABSTRACT
Gliosarcoma, a variant of glioblastoma multiforme, is a dimorphic tumor known for its intra-axial occurrence and poor survival of less than a year. Here is an 11-year-old boy with gliosarcoma. He had a near total excision and postoperative chemoradiotherapy. He has lived through the disease for over 34 months with a residual disease.This case report is to report an unusual long survival of gliosarcoma in a teenager (Ravisankar et al., 2012).

No MeSH data available.


Related in: MedlinePlus

Gross post-op specimen.
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fig2: Gross post-op specimen.

Mentions: An 11-year-old boy presented to the outpatient department with headache and vomiting in August 2011 [1]. CT scan showed a contrast enhancing isodense space occupying lesion with areas of calcification in right frontal cortex with surrounding edema (Figure 1). Craniotomy was done and part of the lesion was sent for squash cytology. The smear appeared cellular showing discohesive sheets and clusters of pleomorphic oval to polygonal cells with abundant eosinophilic cytoplasm some showing cytoplasmic vacuolation and marked nuclear atypia in a background of necrosis and hemorrhage. A suggestion of atypical teratoid/rhabdoid tumour was made. A near total excision of the space occupying lesion in the right parietooccipital region was done and sent for histopathologic examination. Grossly, the specimen was received as multiple irregular gray white soft tissue fragments ranging from 0.5 × 0.5 cm to 4 × 3 × 2 cm. External surface appears irregular and nodular. Cut surface appears variegated with gray tan areas, glistening areas, cystic areas, and hemorrhagic areas. Few areas of calcification are also seen (Figure 2).


Malignant pediatric gliosarcoma defies general survival data.

Martin J, Devadoss P, Kannan K, Kumar Sundarraj S - Case Rep Med (2014)

Gross post-op specimen.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4281457&req=5

fig2: Gross post-op specimen.
Mentions: An 11-year-old boy presented to the outpatient department with headache and vomiting in August 2011 [1]. CT scan showed a contrast enhancing isodense space occupying lesion with areas of calcification in right frontal cortex with surrounding edema (Figure 1). Craniotomy was done and part of the lesion was sent for squash cytology. The smear appeared cellular showing discohesive sheets and clusters of pleomorphic oval to polygonal cells with abundant eosinophilic cytoplasm some showing cytoplasmic vacuolation and marked nuclear atypia in a background of necrosis and hemorrhage. A suggestion of atypical teratoid/rhabdoid tumour was made. A near total excision of the space occupying lesion in the right parietooccipital region was done and sent for histopathologic examination. Grossly, the specimen was received as multiple irregular gray white soft tissue fragments ranging from 0.5 × 0.5 cm to 4 × 3 × 2 cm. External surface appears irregular and nodular. Cut surface appears variegated with gray tan areas, glistening areas, cystic areas, and hemorrhagic areas. Few areas of calcification are also seen (Figure 2).

Bottom Line: Gliosarcoma, a variant of glioblastoma multiforme, is a dimorphic tumor known for its intra-axial occurrence and poor survival of less than a year.Here is an 11-year-old boy with gliosarcoma.He has lived through the disease for over 34 months with a residual disease.This case report is to report an unusual long survival of gliosarcoma in a teenager (Ravisankar et al., 2012).

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Oncology, Madras Medical College, Chennai, India.

ABSTRACT
Gliosarcoma, a variant of glioblastoma multiforme, is a dimorphic tumor known for its intra-axial occurrence and poor survival of less than a year. Here is an 11-year-old boy with gliosarcoma. He had a near total excision and postoperative chemoradiotherapy. He has lived through the disease for over 34 months with a residual disease.This case report is to report an unusual long survival of gliosarcoma in a teenager (Ravisankar et al., 2012).

No MeSH data available.


Related in: MedlinePlus