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ECR-MAPK regulation in liver early development.

Zhao XJ, Zhuo H - Biomed Res Int (2014)

Bottom Line: Significance analysis of microarrays, qPCR verification, drug induction/inhibition assays, and metabonomics indicated that alpha-2u globulin (extracellular region)-socs2 (-SH2-containing signals/receptor tyrosine kinases)-ppp2r2a/pik3c3 (MAPK signaling)-hsd3b5/cav2 (metabolism/organization) plays a vital role in early development.Taken together, early development of male rats is ECR and MAPK-mediated coordination of cancer-like growth and negative regulations.Our data represent the first comprehensive description of early individual development, which could be a valuable basis for understanding the functioning of the gene interaction network of infant development.

View Article: PubMed Central - PubMed

Affiliation: School of Biology and Pharmaceutical Engineering, Wuhan Polytechnic University, Collaborative Innovation Center of Processing of Agricultural Products in Hubei Province, No. 68 South Xuefu Road, Changqing Garden, Wuhan 430023, China ; Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, West No. 30 Xiaohongshan, Wuhan 430071, China.

ABSTRACT
Early growth is connected to a key link between embryonic development and aging. In this paper, liver gene expression profiles were assayed at postnatal day 22 and week 16 of age. Meanwhile another independent animal experiment and cell culture were carried out for validation. Significance analysis of microarrays, qPCR verification, drug induction/inhibition assays, and metabonomics indicated that alpha-2u globulin (extracellular region)-socs2 (-SH2-containing signals/receptor tyrosine kinases)-ppp2r2a/pik3c3 (MAPK signaling)-hsd3b5/cav2 (metabolism/organization) plays a vital role in early development. Taken together, early development of male rats is ECR and MAPK-mediated coordination of cancer-like growth and negative regulations. Our data represent the first comprehensive description of early individual development, which could be a valuable basis for understanding the functioning of the gene interaction network of infant development.

Show MeSH
Gene correlation network of liver early development. obp3, extracellular region and transporter, was correlated to membrane (ust5r, stac3, cdh17, mme, olr59, gpm6a, tmem163, abcg8, abcd2, and abcc3), adapter (stac3, socs2), transcription (zfp37, ccna2, asns, and rgd1562284), immune (rt1-ce5, rt1-aw2, cxcl13, and cyfip2), and redox (hsd3b5, cyp2c13, cyp2a2, dhrs7, hao2, akr1c1, nox4, inmt, dusp1, mettl7b, ppp2r2a, cyp17a1, and akr1b7). Genes were correlated using 2D STOCSY, P < 0.05. Keys: 1,2 obp3; 3,4,7 rup2; 5, hsdsb5; 6, dhrs7; 8, cyp2c13; 16, ust5r; 19, stac3; 22, zfp37; 32, ppp2r2a; 33, socs2; 39, pcdh17; 41, abcg8; 44, ccna2; 49, s100g; 50, cxcl13; 53, tox; 62, akr1b7. The corresponding genes of numbers were listed in Supplementary Table  2.
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fig1: Gene correlation network of liver early development. obp3, extracellular region and transporter, was correlated to membrane (ust5r, stac3, cdh17, mme, olr59, gpm6a, tmem163, abcg8, abcd2, and abcc3), adapter (stac3, socs2), transcription (zfp37, ccna2, asns, and rgd1562284), immune (rt1-ce5, rt1-aw2, cxcl13, and cyfip2), and redox (hsd3b5, cyp2c13, cyp2a2, dhrs7, hao2, akr1c1, nox4, inmt, dusp1, mettl7b, ppp2r2a, cyp17a1, and akr1b7). Genes were correlated using 2D STOCSY, P < 0.05. Keys: 1,2 obp3; 3,4,7 rup2; 5, hsdsb5; 6, dhrs7; 8, cyp2c13; 16, ust5r; 19, stac3; 22, zfp37; 32, ppp2r2a; 33, socs2; 39, pcdh17; 41, abcg8; 44, ccna2; 49, s100g; 50, cxcl13; 53, tox; 62, akr1b7. The corresponding genes of numbers were listed in Supplementary Table  2.

Mentions: Furthermore, obp3, extracellular region and transporter, was correlated to membrane (ust5r, stac3, cdh17, mme, olr59, gpm6a, tmem163, abcg8, abcd2, and abcc3), adapter (stac3, socs2), transcription (zfp37, ccna2, asns, and rgd1562284), immune (rt1-ce5, rt1-aw2, cxcl13, and cyfip2), and redox (hsd3b5, cyp2c13, cyp2a2, dhrs7, hao2, akr1c1, nox4, inmt, dusp1, mettl7b, ppp2r2a, cyp17a1, and akr1b7) (/r / >/rcutoff / = 0.632, P < 0.05) (Figure 1, Supplementary Table 2).


ECR-MAPK regulation in liver early development.

Zhao XJ, Zhuo H - Biomed Res Int (2014)

Gene correlation network of liver early development. obp3, extracellular region and transporter, was correlated to membrane (ust5r, stac3, cdh17, mme, olr59, gpm6a, tmem163, abcg8, abcd2, and abcc3), adapter (stac3, socs2), transcription (zfp37, ccna2, asns, and rgd1562284), immune (rt1-ce5, rt1-aw2, cxcl13, and cyfip2), and redox (hsd3b5, cyp2c13, cyp2a2, dhrs7, hao2, akr1c1, nox4, inmt, dusp1, mettl7b, ppp2r2a, cyp17a1, and akr1b7). Genes were correlated using 2D STOCSY, P < 0.05. Keys: 1,2 obp3; 3,4,7 rup2; 5, hsdsb5; 6, dhrs7; 8, cyp2c13; 16, ust5r; 19, stac3; 22, zfp37; 32, ppp2r2a; 33, socs2; 39, pcdh17; 41, abcg8; 44, ccna2; 49, s100g; 50, cxcl13; 53, tox; 62, akr1b7. The corresponding genes of numbers were listed in Supplementary Table  2.
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Related In: Results  -  Collection

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fig1: Gene correlation network of liver early development. obp3, extracellular region and transporter, was correlated to membrane (ust5r, stac3, cdh17, mme, olr59, gpm6a, tmem163, abcg8, abcd2, and abcc3), adapter (stac3, socs2), transcription (zfp37, ccna2, asns, and rgd1562284), immune (rt1-ce5, rt1-aw2, cxcl13, and cyfip2), and redox (hsd3b5, cyp2c13, cyp2a2, dhrs7, hao2, akr1c1, nox4, inmt, dusp1, mettl7b, ppp2r2a, cyp17a1, and akr1b7). Genes were correlated using 2D STOCSY, P < 0.05. Keys: 1,2 obp3; 3,4,7 rup2; 5, hsdsb5; 6, dhrs7; 8, cyp2c13; 16, ust5r; 19, stac3; 22, zfp37; 32, ppp2r2a; 33, socs2; 39, pcdh17; 41, abcg8; 44, ccna2; 49, s100g; 50, cxcl13; 53, tox; 62, akr1b7. The corresponding genes of numbers were listed in Supplementary Table  2.
Mentions: Furthermore, obp3, extracellular region and transporter, was correlated to membrane (ust5r, stac3, cdh17, mme, olr59, gpm6a, tmem163, abcg8, abcd2, and abcc3), adapter (stac3, socs2), transcription (zfp37, ccna2, asns, and rgd1562284), immune (rt1-ce5, rt1-aw2, cxcl13, and cyfip2), and redox (hsd3b5, cyp2c13, cyp2a2, dhrs7, hao2, akr1c1, nox4, inmt, dusp1, mettl7b, ppp2r2a, cyp17a1, and akr1b7) (/r / >/rcutoff / = 0.632, P < 0.05) (Figure 1, Supplementary Table 2).

Bottom Line: Significance analysis of microarrays, qPCR verification, drug induction/inhibition assays, and metabonomics indicated that alpha-2u globulin (extracellular region)-socs2 (-SH2-containing signals/receptor tyrosine kinases)-ppp2r2a/pik3c3 (MAPK signaling)-hsd3b5/cav2 (metabolism/organization) plays a vital role in early development.Taken together, early development of male rats is ECR and MAPK-mediated coordination of cancer-like growth and negative regulations.Our data represent the first comprehensive description of early individual development, which could be a valuable basis for understanding the functioning of the gene interaction network of infant development.

View Article: PubMed Central - PubMed

Affiliation: School of Biology and Pharmaceutical Engineering, Wuhan Polytechnic University, Collaborative Innovation Center of Processing of Agricultural Products in Hubei Province, No. 68 South Xuefu Road, Changqing Garden, Wuhan 430023, China ; Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, West No. 30 Xiaohongshan, Wuhan 430071, China.

ABSTRACT
Early growth is connected to a key link between embryonic development and aging. In this paper, liver gene expression profiles were assayed at postnatal day 22 and week 16 of age. Meanwhile another independent animal experiment and cell culture were carried out for validation. Significance analysis of microarrays, qPCR verification, drug induction/inhibition assays, and metabonomics indicated that alpha-2u globulin (extracellular region)-socs2 (-SH2-containing signals/receptor tyrosine kinases)-ppp2r2a/pik3c3 (MAPK signaling)-hsd3b5/cav2 (metabolism/organization) plays a vital role in early development. Taken together, early development of male rats is ECR and MAPK-mediated coordination of cancer-like growth and negative regulations. Our data represent the first comprehensive description of early individual development, which could be a valuable basis for understanding the functioning of the gene interaction network of infant development.

Show MeSH