Limits...
Safe and Successful Yttrium-90 Resin Microsphere Radioembolization in a Heavily Pretreated Patient with Chemorefractory Colorectal Liver Metastases after Biliary Stent Placement above the Papilla.

Sotirchos VS, Petre EN, Brown KT, Brody LA, D'Angelica MI, DeMatteo RP, Kemeny NE, Sofocleous CT - Case Reports Hepatol (2014)

Bottom Line: We report a case of safe and successful yttrium-90 resin microsphere radioembolization in a patient with a long history of multiple recurrent colon cancer hepatic metastases progressing after hepatic resections, hepatic arterial chemotherapy, and multiple regimens of systemic chemotherapy.One month prior to radioembolization, a biliary stent was placed above the level of the ampulla to relieve tumor-related biliary obstruction and normalize bilirubin levels.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Interventional Radiology Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

ABSTRACT
We report a case of safe and successful yttrium-90 resin microsphere radioembolization in a patient with a long history of multiple recurrent colon cancer hepatic metastases progressing after hepatic resections, hepatic arterial chemotherapy, and multiple regimens of systemic chemotherapy. One month prior to radioembolization, a biliary stent was placed above the level of the ampulla to relieve tumor-related biliary obstruction and normalize bilirubin levels.

No MeSH data available.


Related in: MedlinePlus

Axial PET-CT images (a) before biliary drainage and SIRT and (b) two months after SIRT, at the level of segments 2 and 3. Significant response to treatment is evident, with resolution of FDG avid hepatic metastases (arrows). However, progression of extrahepatic disease was noted in portocaval and periaortic nodes.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4281443&req=5

fig3: Axial PET-CT images (a) before biliary drainage and SIRT and (b) two months after SIRT, at the level of segments 2 and 3. Significant response to treatment is evident, with resolution of FDG avid hepatic metastases (arrows). However, progression of extrahepatic disease was noted in portocaval and periaortic nodes.

Mentions: Imaging revealed complete PET response to SIRT and resolution of SUV activity within the liver (Figure 3). Two months after the procedure, despite control of hepatic disease, progression in nodal sites outside the liver and enlarging pulmonary nodules mandated reinitiation of systemic chemotherapy with 5-FU/leucovorin and panitumumab, which temporarily controlled metastatic disease. The patient eventually succumbed to his illness at an outside hospital seven months after SIRT and 10.5 years after initial diagnosis. There was no evident progression of CLM on the latest available CT scan obtained 5 months after SIRT, despite extrahepatic nodal disease involvement.


Safe and Successful Yttrium-90 Resin Microsphere Radioembolization in a Heavily Pretreated Patient with Chemorefractory Colorectal Liver Metastases after Biliary Stent Placement above the Papilla.

Sotirchos VS, Petre EN, Brown KT, Brody LA, D'Angelica MI, DeMatteo RP, Kemeny NE, Sofocleous CT - Case Reports Hepatol (2014)

Axial PET-CT images (a) before biliary drainage and SIRT and (b) two months after SIRT, at the level of segments 2 and 3. Significant response to treatment is evident, with resolution of FDG avid hepatic metastases (arrows). However, progression of extrahepatic disease was noted in portocaval and periaortic nodes.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4281443&req=5

fig3: Axial PET-CT images (a) before biliary drainage and SIRT and (b) two months after SIRT, at the level of segments 2 and 3. Significant response to treatment is evident, with resolution of FDG avid hepatic metastases (arrows). However, progression of extrahepatic disease was noted in portocaval and periaortic nodes.
Mentions: Imaging revealed complete PET response to SIRT and resolution of SUV activity within the liver (Figure 3). Two months after the procedure, despite control of hepatic disease, progression in nodal sites outside the liver and enlarging pulmonary nodules mandated reinitiation of systemic chemotherapy with 5-FU/leucovorin and panitumumab, which temporarily controlled metastatic disease. The patient eventually succumbed to his illness at an outside hospital seven months after SIRT and 10.5 years after initial diagnosis. There was no evident progression of CLM on the latest available CT scan obtained 5 months after SIRT, despite extrahepatic nodal disease involvement.

Bottom Line: We report a case of safe and successful yttrium-90 resin microsphere radioembolization in a patient with a long history of multiple recurrent colon cancer hepatic metastases progressing after hepatic resections, hepatic arterial chemotherapy, and multiple regimens of systemic chemotherapy.One month prior to radioembolization, a biliary stent was placed above the level of the ampulla to relieve tumor-related biliary obstruction and normalize bilirubin levels.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Interventional Radiology Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

ABSTRACT
We report a case of safe and successful yttrium-90 resin microsphere radioembolization in a patient with a long history of multiple recurrent colon cancer hepatic metastases progressing after hepatic resections, hepatic arterial chemotherapy, and multiple regimens of systemic chemotherapy. One month prior to radioembolization, a biliary stent was placed above the level of the ampulla to relieve tumor-related biliary obstruction and normalize bilirubin levels.

No MeSH data available.


Related in: MedlinePlus