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Mathematical modeling of radiofrequency ablation for varicose veins.

Choi SY, Kwak BK, Seo T - Comput Math Methods Med (2014)

Bottom Line: The lower the blood velocity, the higher the temperature in the vein wall and the greater the tissue damage.The generated RF energy induces a temperature rise of the blood in the lumen and leads to an occlusion of the blood vessel.The vein wall absorbs more energy in the low pullback velocity than in the high one.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology and Medical Research Institute, School of Medicine, Ewha Womans University, 1071 Anyangcheon-ro, Yangcheon-gu, Seoul 158-710, Republic of Korea.

ABSTRACT
We present a three-dimensional mathematical model for the study of radiofrequency ablation (RFA) with blood flow for varicose vein. The model designed to analyze temperature distribution heated by radiofrequency energy and cooled by blood flow includes a cylindrically symmetric blood vessel with a homogeneous vein wall. The simulated blood velocity conditions are U = 0, 1, 2.5, 5, 10, 20, and 40 mm/s. The lower the blood velocity, the higher the temperature in the vein wall and the greater the tissue damage. The region that is influenced by temperature in the case of the stagnant flow occupies approximately 28.5% of the whole geometry, while the region that is influenced by temperature in the case of continuously moving electrode against the flow direction is about 50%. The generated RF energy induces a temperature rise of the blood in the lumen and leads to an occlusion of the blood vessel. The result of the study demonstrated that higher blood velocity led to smaller thermal region and lower ablation efficiency. Since the peak temperature along the venous wall depends on the blood velocity and pullback velocity, the temperature distribution in the model influences ablation efficiency. The vein wall absorbs more energy in the low pullback velocity than in the high one.

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Related in: MedlinePlus

Schematic diagram of model used for simulation: D is the vessel diameter (2R), d is the diameter of electrode, L is the length of the electrode, and t is the vessel wall thickness.
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fig1: Schematic diagram of model used for simulation: D is the vessel diameter (2R), d is the diameter of electrode, L is the length of the electrode, and t is the vessel wall thickness.

Mentions: For the simplification of the geometric model, we ignored the valve leaflets in vein. As shown in Figure 1 the geometry of the vein and electrode has been simplified for half of the vein and tissue. In the study the geometric domains are composed of the lumen and the vessel wall. The lumen is 3 mm in diameter with 60 mm length, while the vein wall is 0.4 mm in thickness with the tunica intima at the interface between blood and vessel wall and tunica adventitia. The electrode is 0.4 mm in diameter with 10 mm length, which is a unitary transformation for 0.4064 mm. The electrode is positioned in the middle of lumen and 20 mm apart from inlet region as shown in Figure 1. In the geometry we assumed that the RF power was supplied to the electrode to conduct the radiofrequency ablation until there is an increase in uncontrolled impedance. In the simulation we assumed that the electrode moves continuously with a constant pullback velocity against the blood flow direction.


Mathematical modeling of radiofrequency ablation for varicose veins.

Choi SY, Kwak BK, Seo T - Comput Math Methods Med (2014)

Schematic diagram of model used for simulation: D is the vessel diameter (2R), d is the diameter of electrode, L is the length of the electrode, and t is the vessel wall thickness.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4281440&req=5

fig1: Schematic diagram of model used for simulation: D is the vessel diameter (2R), d is the diameter of electrode, L is the length of the electrode, and t is the vessel wall thickness.
Mentions: For the simplification of the geometric model, we ignored the valve leaflets in vein. As shown in Figure 1 the geometry of the vein and electrode has been simplified for half of the vein and tissue. In the study the geometric domains are composed of the lumen and the vessel wall. The lumen is 3 mm in diameter with 60 mm length, while the vein wall is 0.4 mm in thickness with the tunica intima at the interface between blood and vessel wall and tunica adventitia. The electrode is 0.4 mm in diameter with 10 mm length, which is a unitary transformation for 0.4064 mm. The electrode is positioned in the middle of lumen and 20 mm apart from inlet region as shown in Figure 1. In the geometry we assumed that the RF power was supplied to the electrode to conduct the radiofrequency ablation until there is an increase in uncontrolled impedance. In the simulation we assumed that the electrode moves continuously with a constant pullback velocity against the blood flow direction.

Bottom Line: The lower the blood velocity, the higher the temperature in the vein wall and the greater the tissue damage.The generated RF energy induces a temperature rise of the blood in the lumen and leads to an occlusion of the blood vessel.The vein wall absorbs more energy in the low pullback velocity than in the high one.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology and Medical Research Institute, School of Medicine, Ewha Womans University, 1071 Anyangcheon-ro, Yangcheon-gu, Seoul 158-710, Republic of Korea.

ABSTRACT
We present a three-dimensional mathematical model for the study of radiofrequency ablation (RFA) with blood flow for varicose vein. The model designed to analyze temperature distribution heated by radiofrequency energy and cooled by blood flow includes a cylindrically symmetric blood vessel with a homogeneous vein wall. The simulated blood velocity conditions are U = 0, 1, 2.5, 5, 10, 20, and 40 mm/s. The lower the blood velocity, the higher the temperature in the vein wall and the greater the tissue damage. The region that is influenced by temperature in the case of the stagnant flow occupies approximately 28.5% of the whole geometry, while the region that is influenced by temperature in the case of continuously moving electrode against the flow direction is about 50%. The generated RF energy induces a temperature rise of the blood in the lumen and leads to an occlusion of the blood vessel. The result of the study demonstrated that higher blood velocity led to smaller thermal region and lower ablation efficiency. Since the peak temperature along the venous wall depends on the blood velocity and pullback velocity, the temperature distribution in the model influences ablation efficiency. The vein wall absorbs more energy in the low pullback velocity than in the high one.

Show MeSH
Related in: MedlinePlus