Limits...
Hot spots and future directions of research on the neuroprotective effects of nimodipine.

Li R - Neural Regen Res (2014)

Bottom Line: Nimodipine, a typical calcium antagonist, can cross the blood-brain barrier and act selectively at neurons and blood vessels of target tissues, thus exerting neuroprotective effects.We retrieved 425 articles on the neuroprotective effects of nimodipine that were indexed in the Web of the Science database between 2000 and 2014.The reference co-citation network was plotted, and the high frequency key words in these publications were used to analyze the research fronts and development trends for nimodipine neuroprotection.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Affiliated Central Hospital of Shenyang Medical College, Shenyang, Liaoning Province, China.

ABSTRACT
Calcium antagonists are widely used in the clinical treatment of ischemic cerebrovascular disease because of their vascular and neuroprotective effects. Nimodipine, a typical calcium antagonist, can cross the blood-brain barrier and act selectively at neurons and blood vessels of target tissues, thus exerting neuroprotective effects. The aim of the present study was to explore the hot spots and future trends of research on the neuroprotective effects of nimodipine. We retrieved 425 articles on the neuroprotective effects of nimodipine that were indexed in the Web of the Science database between 2000 and 2014. The retrieved articles were analyzed using document analysis reporting and the derived information function in the Web of Science, and the information visualization software CiteSpace III. The reference co-citation network was plotted, and the high frequency key words in these publications were used to analyze the research fronts and development trends for nimodipine neuroprotection. According to these co-citation clusters, the research front of nimodipine neuroprotection is the use of randomized controlled trials to study nimodipine intervention of subarachnoid hemorrhage. Using time zone view analysis on hot spots labeled with a key word, the areas of interest in the field of nimodipine neuroprotection are nimodipine pharmacology and therapeutics, blood-brain barrier, trials, and anti-angiospasm.

No MeSH data available.


Related in: MedlinePlus

Co-citaion-burst term visualization analysis network knowledge map.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4281435&req=5

Figure 6: Co-citaion-burst term visualization analysis network knowledge map.

Mentions: Visualized networks for co-cited burst terms in articles on the neuroprotective effect of nimodipine that were indexed in the Web of Science database during 2000–2014 were created using Citespace III software and based on the following parameters: time slicing = 1; time zone = 5 years (2000–2014, inclusive); threshold value = (2, 2, 20), (4, 3, 20), (4, 3, 20); node type = “burst terms”. Data retrieved were processed in 15 different periods, and 50 documents with high citation frequency were selected in each time zone. The networks were streamlined with the Pathfinder network scaling method, and the co-citation-burst term visualization analysis network was mapped (Figure 6), revealing 617 nodes and 2,325 lines. The highly cited publications with a centrality of more than 0.09 are shown in Table 2.


Hot spots and future directions of research on the neuroprotective effects of nimodipine.

Li R - Neural Regen Res (2014)

Co-citaion-burst term visualization analysis network knowledge map.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4281435&req=5

Figure 6: Co-citaion-burst term visualization analysis network knowledge map.
Mentions: Visualized networks for co-cited burst terms in articles on the neuroprotective effect of nimodipine that were indexed in the Web of Science database during 2000–2014 were created using Citespace III software and based on the following parameters: time slicing = 1; time zone = 5 years (2000–2014, inclusive); threshold value = (2, 2, 20), (4, 3, 20), (4, 3, 20); node type = “burst terms”. Data retrieved were processed in 15 different periods, and 50 documents with high citation frequency were selected in each time zone. The networks were streamlined with the Pathfinder network scaling method, and the co-citation-burst term visualization analysis network was mapped (Figure 6), revealing 617 nodes and 2,325 lines. The highly cited publications with a centrality of more than 0.09 are shown in Table 2.

Bottom Line: Nimodipine, a typical calcium antagonist, can cross the blood-brain barrier and act selectively at neurons and blood vessels of target tissues, thus exerting neuroprotective effects.We retrieved 425 articles on the neuroprotective effects of nimodipine that were indexed in the Web of the Science database between 2000 and 2014.The reference co-citation network was plotted, and the high frequency key words in these publications were used to analyze the research fronts and development trends for nimodipine neuroprotection.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Affiliated Central Hospital of Shenyang Medical College, Shenyang, Liaoning Province, China.

ABSTRACT
Calcium antagonists are widely used in the clinical treatment of ischemic cerebrovascular disease because of their vascular and neuroprotective effects. Nimodipine, a typical calcium antagonist, can cross the blood-brain barrier and act selectively at neurons and blood vessels of target tissues, thus exerting neuroprotective effects. The aim of the present study was to explore the hot spots and future trends of research on the neuroprotective effects of nimodipine. We retrieved 425 articles on the neuroprotective effects of nimodipine that were indexed in the Web of the Science database between 2000 and 2014. The retrieved articles were analyzed using document analysis reporting and the derived information function in the Web of Science, and the information visualization software CiteSpace III. The reference co-citation network was plotted, and the high frequency key words in these publications were used to analyze the research fronts and development trends for nimodipine neuroprotection. According to these co-citation clusters, the research front of nimodipine neuroprotection is the use of randomized controlled trials to study nimodipine intervention of subarachnoid hemorrhage. Using time zone view analysis on hot spots labeled with a key word, the areas of interest in the field of nimodipine neuroprotection are nimodipine pharmacology and therapeutics, blood-brain barrier, trials, and anti-angiospasm.

No MeSH data available.


Related in: MedlinePlus