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Hot spots and future directions of research on the neuroprotective effects of nimodipine.

Li R - Neural Regen Res (2014)

Bottom Line: We retrieved 425 articles on the neuroprotective effects of nimodipine that were indexed in the Web of the Science database between 2000 and 2014.The retrieved articles were analyzed using document analysis reporting and the derived information function in the Web of Science, and the information visualization software CiteSpace III.The reference co-citation network was plotted, and the high frequency key words in these publications were used to analyze the research fronts and development trends for nimodipine neuroprotection.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Affiliated Central Hospital of Shenyang Medical College, Shenyang, Liaoning Province, China.

ABSTRACT
Calcium antagonists are widely used in the clinical treatment of ischemic cerebrovascular disease because of their vascular and neuroprotective effects. Nimodipine, a typical calcium antagonist, can cross the blood-brain barrier and act selectively at neurons and blood vessels of target tissues, thus exerting neuroprotective effects. The aim of the present study was to explore the hot spots and future trends of research on the neuroprotective effects of nimodipine. We retrieved 425 articles on the neuroprotective effects of nimodipine that were indexed in the Web of the Science database between 2000 and 2014. The retrieved articles were analyzed using document analysis reporting and the derived information function in the Web of Science, and the information visualization software CiteSpace III. The reference co-citation network was plotted, and the high frequency key words in these publications were used to analyze the research fronts and development trends for nimodipine neuroprotection. According to these co-citation clusters, the research front of nimodipine neuroprotection is the use of randomized controlled trials to study nimodipine intervention of subarachnoid hemorrhage. Using time zone view analysis on hot spots labeled with a key word, the areas of interest in the field of nimodipine neuroprotection are nimodipine pharmacology and therapeutics, blood-brain barrier, trials, and anti-angiospasm.

No MeSH data available.


Related in: MedlinePlus

Yearly output of publications on the neuroprotective effect of nimodipine indexed in the Web of Science during 2000–2014.
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Figure 1: Yearly output of publications on the neuroprotective effect of nimodipine indexed in the Web of Science during 2000–2014.

Mentions: A total of 425 publications were indexed in the Web of Science database between 2000 and 2014 (Figure 1). The distribution of these publications across different countries is shown in Figure 2.


Hot spots and future directions of research on the neuroprotective effects of nimodipine.

Li R - Neural Regen Res (2014)

Yearly output of publications on the neuroprotective effect of nimodipine indexed in the Web of Science during 2000–2014.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4281435&req=5

Figure 1: Yearly output of publications on the neuroprotective effect of nimodipine indexed in the Web of Science during 2000–2014.
Mentions: A total of 425 publications were indexed in the Web of Science database between 2000 and 2014 (Figure 1). The distribution of these publications across different countries is shown in Figure 2.

Bottom Line: We retrieved 425 articles on the neuroprotective effects of nimodipine that were indexed in the Web of the Science database between 2000 and 2014.The retrieved articles were analyzed using document analysis reporting and the derived information function in the Web of Science, and the information visualization software CiteSpace III.The reference co-citation network was plotted, and the high frequency key words in these publications were used to analyze the research fronts and development trends for nimodipine neuroprotection.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Affiliated Central Hospital of Shenyang Medical College, Shenyang, Liaoning Province, China.

ABSTRACT
Calcium antagonists are widely used in the clinical treatment of ischemic cerebrovascular disease because of their vascular and neuroprotective effects. Nimodipine, a typical calcium antagonist, can cross the blood-brain barrier and act selectively at neurons and blood vessels of target tissues, thus exerting neuroprotective effects. The aim of the present study was to explore the hot spots and future trends of research on the neuroprotective effects of nimodipine. We retrieved 425 articles on the neuroprotective effects of nimodipine that were indexed in the Web of the Science database between 2000 and 2014. The retrieved articles were analyzed using document analysis reporting and the derived information function in the Web of Science, and the information visualization software CiteSpace III. The reference co-citation network was plotted, and the high frequency key words in these publications were used to analyze the research fronts and development trends for nimodipine neuroprotection. According to these co-citation clusters, the research front of nimodipine neuroprotection is the use of randomized controlled trials to study nimodipine intervention of subarachnoid hemorrhage. Using time zone view analysis on hot spots labeled with a key word, the areas of interest in the field of nimodipine neuroprotection are nimodipine pharmacology and therapeutics, blood-brain barrier, trials, and anti-angiospasm.

No MeSH data available.


Related in: MedlinePlus