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Neurochemical mechanism of the gastrointestinal interdigestive migrating motor complex in rats with acute inflammatory stomach ache.

Xu X, Li Q, Zhou L, Ru L - Neural Regen Res (2012)

Bottom Line: Activities of nitric oxide synthase, acetylcholinesterase and vasoactive intestinal peptide neurons were significantly reduced, whereas activities of calcitonin gene-related peptide neurons were significantly increased in the pyloric sphincter muscular layer, myenteric nerve plexus and submucous nerve plexus.Electroacupuncture at Zusanli (ST36) suppressed paroxysmal contraction in rats with formaldehyde-induced stomach ache, and neurons in the enteric nervous system were normal.These results indicated that nitrergic neurons, cholinergic neurons, vasoactive intestinal peptide neurons and calcitonin gene-related peptide neurons in the enteric nervous system may be involved in changes to the gastrointestinal interdigestive migrating motor complex following stomach ache, and that electroacupuncture can regulate this process.

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomy, School of Medicine, Jianghan University, Wuhan 430056, Hubei Province, China.

ABSTRACT
The normal gastrointestinal interdigestive migrating motor complex cycle was interrupted, and paroxysmal contraction appeared after formaldehyde-induced stomach ache. Activities of nitric oxide synthase, acetylcholinesterase and vasoactive intestinal peptide neurons were significantly reduced, whereas activities of calcitonin gene-related peptide neurons were significantly increased in the pyloric sphincter muscular layer, myenteric nerve plexus and submucous nerve plexus. Electroacupuncture at Zusanli (ST36) suppressed paroxysmal contraction in rats with formaldehyde-induced stomach ache, and neurons in the enteric nervous system were normal. These results indicated that nitrergic neurons, cholinergic neurons, vasoactive intestinal peptide neurons and calcitonin gene-related peptide neurons in the enteric nervous system may be involved in changes to the gastrointestinal interdigestive migrating motor complex following stomach ache, and that electroacupuncture can regulate this process.

No MeSH data available.


Related in: MedlinePlus

Effect of electroacupuncture on vasoactive intestinal peptide (VIP)-positive neurons in rats with gastric inflammatory pain (NADPH staining, light microscope; scale bar: 40 μm). Arrows exhibit positive neurons.The number of VIP-positive nerve fibers was significantly reduced in the model group (B), with the presence of low distribution density, weak immunoreactivity, lack of fine reticular fiber structure, and no positive fibers in the lamina propria. The number of positive nerve fibers was increased in the electroacupuncture treatment group (D), and close to the normal control group (A) and electroacupuncture control group (C).
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Figure 5: Effect of electroacupuncture on vasoactive intestinal peptide (VIP)-positive neurons in rats with gastric inflammatory pain (NADPH staining, light microscope; scale bar: 40 μm). Arrows exhibit positive neurons.The number of VIP-positive nerve fibers was significantly reduced in the model group (B), with the presence of low distribution density, weak immunoreactivity, lack of fine reticular fiber structure, and no positive fibers in the lamina propria. The number of positive nerve fibers was increased in the electroacupuncture treatment group (D), and close to the normal control group (A) and electroacupuncture control group (C).


Neurochemical mechanism of the gastrointestinal interdigestive migrating motor complex in rats with acute inflammatory stomach ache.

Xu X, Li Q, Zhou L, Ru L - Neural Regen Res (2012)

Effect of electroacupuncture on vasoactive intestinal peptide (VIP)-positive neurons in rats with gastric inflammatory pain (NADPH staining, light microscope; scale bar: 40 μm). Arrows exhibit positive neurons.The number of VIP-positive nerve fibers was significantly reduced in the model group (B), with the presence of low distribution density, weak immunoreactivity, lack of fine reticular fiber structure, and no positive fibers in the lamina propria. The number of positive nerve fibers was increased in the electroacupuncture treatment group (D), and close to the normal control group (A) and electroacupuncture control group (C).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4281416&req=5

Figure 5: Effect of electroacupuncture on vasoactive intestinal peptide (VIP)-positive neurons in rats with gastric inflammatory pain (NADPH staining, light microscope; scale bar: 40 μm). Arrows exhibit positive neurons.The number of VIP-positive nerve fibers was significantly reduced in the model group (B), with the presence of low distribution density, weak immunoreactivity, lack of fine reticular fiber structure, and no positive fibers in the lamina propria. The number of positive nerve fibers was increased in the electroacupuncture treatment group (D), and close to the normal control group (A) and electroacupuncture control group (C).
Bottom Line: Activities of nitric oxide synthase, acetylcholinesterase and vasoactive intestinal peptide neurons were significantly reduced, whereas activities of calcitonin gene-related peptide neurons were significantly increased in the pyloric sphincter muscular layer, myenteric nerve plexus and submucous nerve plexus.Electroacupuncture at Zusanli (ST36) suppressed paroxysmal contraction in rats with formaldehyde-induced stomach ache, and neurons in the enteric nervous system were normal.These results indicated that nitrergic neurons, cholinergic neurons, vasoactive intestinal peptide neurons and calcitonin gene-related peptide neurons in the enteric nervous system may be involved in changes to the gastrointestinal interdigestive migrating motor complex following stomach ache, and that electroacupuncture can regulate this process.

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomy, School of Medicine, Jianghan University, Wuhan 430056, Hubei Province, China.

ABSTRACT
The normal gastrointestinal interdigestive migrating motor complex cycle was interrupted, and paroxysmal contraction appeared after formaldehyde-induced stomach ache. Activities of nitric oxide synthase, acetylcholinesterase and vasoactive intestinal peptide neurons were significantly reduced, whereas activities of calcitonin gene-related peptide neurons were significantly increased in the pyloric sphincter muscular layer, myenteric nerve plexus and submucous nerve plexus. Electroacupuncture at Zusanli (ST36) suppressed paroxysmal contraction in rats with formaldehyde-induced stomach ache, and neurons in the enteric nervous system were normal. These results indicated that nitrergic neurons, cholinergic neurons, vasoactive intestinal peptide neurons and calcitonin gene-related peptide neurons in the enteric nervous system may be involved in changes to the gastrointestinal interdigestive migrating motor complex following stomach ache, and that electroacupuncture can regulate this process.

No MeSH data available.


Related in: MedlinePlus