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Intraoperative full-dose of partial breast irradiation with electrons delivered by standard linear accelerators for early breast cancer.

Barros AC, Hanna SA, Carvalho HA, Martella E, Andrade FE, Piato JR, Bevilacqua JL - Int J Breast Cancer (2014)

Bottom Line: The cumulative incidence rates of LR, distant metastases, and BC death were 3.2%, 1.5%, and 1.5%, respectively.Complications were rare, and the cosmetic results were excellent or good in most of the patients.Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Mastology Center, Hospital Sírio Libanês, Rua Dona Adma Jafet 91, 01308-050 São Paulo, SP, Brazil ; LIM 02, Discipline of Human Structural Topography, University of São Paulo Medical School, Avenida Dr. Arnaldo 455, 01246-903 São Paulo, SP, Brazil.

ABSTRACT
Purpose. To assess feasibility, efficacy, toxicity, and cosmetic results of intraoperative radiotherapy (IORT) with electrons delivered by standard linear accelerators (Linacs) during breast conserving surgeries for early infiltrating breast cancer (BC) treatment. Materials and Methods. A total of 152 patients with invasive ductal carcinoma (T ≤ 3.0 cm) at low risk for local relapses were treated. All had unicentric lesions by imaging methods and negative sentinel node. After a wide local excision, 21 Gy were delivered on the parenchyma target volume with electron beams. Local recurrences (LR), survival, toxicity, and cosmetic outcomes were analyzed. Results. The median age was 58.3 years (range 40-85); median follow-up was 50.7 months (range 12-101.5). There were 5 cases with LR, 2 cases with distant metastases, and 2 cases with deaths related to BC. The cumulative incidence rates of LR, distant metastases, and BC death were 3.2%, 1.5%, and 1.5%, respectively. Complications were rare, and the cosmetic results were excellent or good in most of the patients. Conclusions. IORT with electrons delivered by standard Linacs is feasible, efficient, and well tolerated and seems to be beneficial for selected patients with early infiltrating BC.

No MeSH data available.


Related in: MedlinePlus

Preparation for delivering irradiation.
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fig1: Preparation for delivering irradiation.

Mentions: The electron beam energy was chosen after measuring the gland thickness by inserting a needle perpendicularly to the parenchyma. A sterile, round collimator was connected to the gantry of the Linac and gently placed into the surgical bed by appropriated mobilization of the couch and gantry (Figure 1). The choice of collimator diameter was made according to each case but was usually up to 6 cm.


Intraoperative full-dose of partial breast irradiation with electrons delivered by standard linear accelerators for early breast cancer.

Barros AC, Hanna SA, Carvalho HA, Martella E, Andrade FE, Piato JR, Bevilacqua JL - Int J Breast Cancer (2014)

Preparation for delivering irradiation.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4281392&req=5

fig1: Preparation for delivering irradiation.
Mentions: The electron beam energy was chosen after measuring the gland thickness by inserting a needle perpendicularly to the parenchyma. A sterile, round collimator was connected to the gantry of the Linac and gently placed into the surgical bed by appropriated mobilization of the couch and gantry (Figure 1). The choice of collimator diameter was made according to each case but was usually up to 6 cm.

Bottom Line: The cumulative incidence rates of LR, distant metastases, and BC death were 3.2%, 1.5%, and 1.5%, respectively.Complications were rare, and the cosmetic results were excellent or good in most of the patients.Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Mastology Center, Hospital Sírio Libanês, Rua Dona Adma Jafet 91, 01308-050 São Paulo, SP, Brazil ; LIM 02, Discipline of Human Structural Topography, University of São Paulo Medical School, Avenida Dr. Arnaldo 455, 01246-903 São Paulo, SP, Brazil.

ABSTRACT
Purpose. To assess feasibility, efficacy, toxicity, and cosmetic results of intraoperative radiotherapy (IORT) with electrons delivered by standard linear accelerators (Linacs) during breast conserving surgeries for early infiltrating breast cancer (BC) treatment. Materials and Methods. A total of 152 patients with invasive ductal carcinoma (T ≤ 3.0 cm) at low risk for local relapses were treated. All had unicentric lesions by imaging methods and negative sentinel node. After a wide local excision, 21 Gy were delivered on the parenchyma target volume with electron beams. Local recurrences (LR), survival, toxicity, and cosmetic outcomes were analyzed. Results. The median age was 58.3 years (range 40-85); median follow-up was 50.7 months (range 12-101.5). There were 5 cases with LR, 2 cases with distant metastases, and 2 cases with deaths related to BC. The cumulative incidence rates of LR, distant metastases, and BC death were 3.2%, 1.5%, and 1.5%, respectively. Complications were rare, and the cosmetic results were excellent or good in most of the patients. Conclusions. IORT with electrons delivered by standard Linacs is feasible, efficient, and well tolerated and seems to be beneficial for selected patients with early infiltrating BC.

No MeSH data available.


Related in: MedlinePlus