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The roles of CD147 and/or cyclophilin A in kidney diseases.

Qu X, Wang C, Zhang J, Qie G, Zhou J - Mediators Inflamm. (2014)

Bottom Line: CD147 is a widely expressed integral plasma membrane glycoprotein and has been involved in a variety of physiological and pathological activities in combination with different partners, including cyclophilins, caveolin-1, monocarboxylate transporters, and integrins.Recent data demonstrate that both CyPA and CD147 significantly contribute to renal inflammation, acute kidney injury, renal fibrosis, and renal cell carcinoma.Here we review the current understanding of cyclophilin A and CD147 expression and functions in kidney diseases and potential implications for treatment of kidney diseases.

View Article: PubMed Central - PubMed

Affiliation: Department of Critical Care Medicine, Shandong Provincial Hospital, Shandong University, 324 Jingwu Road, Jinan 250021, China ; Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, 6 Tiantan Xili, Beijing 100050, China.

ABSTRACT
CD147 is a widely expressed integral plasma membrane glycoprotein and has been involved in a variety of physiological and pathological activities in combination with different partners, including cyclophilins, caveolin-1, monocarboxylate transporters, and integrins. Recent data demonstrate that both CyPA and CD147 significantly contribute to renal inflammation, acute kidney injury, renal fibrosis, and renal cell carcinoma. Here we review the current understanding of cyclophilin A and CD147 expression and functions in kidney diseases and potential implications for treatment of kidney diseases.

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Related in: MedlinePlus

Illustration of CD147-interacting proteins and functions. MCT: monocarboxylate transporter; MMP: matrix metalloproteinase.
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Related In: Results  -  Collection


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fig1: Illustration of CD147-interacting proteins and functions. MCT: monocarboxylate transporter; MMP: matrix metalloproteinase.

Mentions: To our knowledge, CD147 exerts various roles through interacting with different ligands. Yurchenko et al. were the first to confirm CD147 as the principal signalling receptor for extracellular cyclophilins [21]. A large number of evidences have also identified CD147 as the principal cell surface receptor for introduction of Cyps signals into target cells [49]. CD147 binding partners are not fully known yet and the number is likely to grow in the future. Currently, besides the above mentioned, CD147 binding partners include cyclophilins, caveolin-1, monocarboxylate transporters (MCT-1,3,4) [50], integrins [51], E-selectin [2], S100A9, CD98, CD44, and CD147 itself [52] (Figure 1). The extracellular domain of CD147 was demonstrated to interact with caveolin-1, cyclophilins, β1 integrin, and CD147 itself, and the transmembrane domain is associated with CD43, MCT, and syndecan [43, 53]. The ligands including caveolin-1 and E-selectin are simply introduced as follows.


The roles of CD147 and/or cyclophilin A in kidney diseases.

Qu X, Wang C, Zhang J, Qie G, Zhou J - Mediators Inflamm. (2014)

Illustration of CD147-interacting proteins and functions. MCT: monocarboxylate transporter; MMP: matrix metalloproteinase.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4281390&req=5

fig1: Illustration of CD147-interacting proteins and functions. MCT: monocarboxylate transporter; MMP: matrix metalloproteinase.
Mentions: To our knowledge, CD147 exerts various roles through interacting with different ligands. Yurchenko et al. were the first to confirm CD147 as the principal signalling receptor for extracellular cyclophilins [21]. A large number of evidences have also identified CD147 as the principal cell surface receptor for introduction of Cyps signals into target cells [49]. CD147 binding partners are not fully known yet and the number is likely to grow in the future. Currently, besides the above mentioned, CD147 binding partners include cyclophilins, caveolin-1, monocarboxylate transporters (MCT-1,3,4) [50], integrins [51], E-selectin [2], S100A9, CD98, CD44, and CD147 itself [52] (Figure 1). The extracellular domain of CD147 was demonstrated to interact with caveolin-1, cyclophilins, β1 integrin, and CD147 itself, and the transmembrane domain is associated with CD43, MCT, and syndecan [43, 53]. The ligands including caveolin-1 and E-selectin are simply introduced as follows.

Bottom Line: CD147 is a widely expressed integral plasma membrane glycoprotein and has been involved in a variety of physiological and pathological activities in combination with different partners, including cyclophilins, caveolin-1, monocarboxylate transporters, and integrins.Recent data demonstrate that both CyPA and CD147 significantly contribute to renal inflammation, acute kidney injury, renal fibrosis, and renal cell carcinoma.Here we review the current understanding of cyclophilin A and CD147 expression and functions in kidney diseases and potential implications for treatment of kidney diseases.

View Article: PubMed Central - PubMed

Affiliation: Department of Critical Care Medicine, Shandong Provincial Hospital, Shandong University, 324 Jingwu Road, Jinan 250021, China ; Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, 6 Tiantan Xili, Beijing 100050, China.

ABSTRACT
CD147 is a widely expressed integral plasma membrane glycoprotein and has been involved in a variety of physiological and pathological activities in combination with different partners, including cyclophilins, caveolin-1, monocarboxylate transporters, and integrins. Recent data demonstrate that both CyPA and CD147 significantly contribute to renal inflammation, acute kidney injury, renal fibrosis, and renal cell carcinoma. Here we review the current understanding of cyclophilin A and CD147 expression and functions in kidney diseases and potential implications for treatment of kidney diseases.

Show MeSH
Related in: MedlinePlus