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LC3A-positive "stone-like" structures predict an adverse prognosis of gastric cancer.

Liao W, Sun L, Wang C, Huang H, Liu J, Liao W, Shi M - Anat Rec (Hoboken) (2014)

Bottom Line: Two distinct patterns of LC3A immunostaining (diffuse cytoplasmic expression and "stone-like" structures) were observed in GC tissues.In addition, a high number of LC3A-positive "stone-like" structures was closely associated with an increased risk of recurrence after radical resection of stages I-III cancer (P < 0.001; HR = 0.205) and was associated with a lower overall survival rate for stage IV cancer (P < 0.001; HR = 0.364).Taken together, our data demonstrate that LC3A-positive "stone-like" structures can be used as an independent biomarker for an adverse prognosis of GC, suggesting that "stone-like" structures are correlated with the malignancy of this disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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Related in: MedlinePlus

Kaplan‐Meier analysis of the influence of the two patterns of LC3A staining in patients with GC at different stages. A: Postoperative recurrence of stages I–III disease was analyzed in relation to the number of LC3A‐positive SLS. Separate analyses were also carried out for patients from stage II (B) or stage III (C). D: Overall survival of stage IV patients according to the number of LC3A‐positive SLS. E: Postoperative recurrence of stages I–III disease in relation to diffuse cytoplasmic LC3A staining. F: Overall survival of stage IV GC patients in relation to diffuse cytoplasmic staining for LC3A.
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ar22895-fig-0005: Kaplan‐Meier analysis of the influence of the two patterns of LC3A staining in patients with GC at different stages. A: Postoperative recurrence of stages I–III disease was analyzed in relation to the number of LC3A‐positive SLS. Separate analyses were also carried out for patients from stage II (B) or stage III (C). D: Overall survival of stage IV patients according to the number of LC3A‐positive SLS. E: Postoperative recurrence of stages I–III disease in relation to diffuse cytoplasmic LC3A staining. F: Overall survival of stage IV GC patients in relation to diffuse cytoplasmic staining for LC3A.

Mentions: To evaluate the prognosis of the GC patients in relation to LC3A‐positive SLS and the diffuse cytoplasmic LC3A staining, Kaplan‐Meier survival analysis was performed. This showed that LC3A‐positive SLS were associated with an increased risk of postoperative recurrence in stages I–III (P < 0.001; HR = 0.205). The median time to recurrence was 12 months in stages I–III patients with a high number of LC3A‐positive SLS versus 40 months in those with a low number (Fig. 5A). Stratified analysis of postoperative recurrence was also performed to assess the influence of LC3A‐positive SLS in stage II patients (Fig. 5B) and stage III patients (Fig. 5C). The results indicated that LC3A‐positive SLS predicted postoperative recurrence in both stage II (P < 0.001; HR = 0.025) and stage III (P < 0.001; HR = 0.067). Due to the limited number of stage I patients, stratified analysis of postoperative recurrence was not performed. In stage IV patients, a high number of LC3A‐positive SLS was associated with lower overall survival rate (P < 0.001; HR = 0.364) (Fig. 5D). The median survival time of stage IV patients with a high number of LC3A‐positive SLS was 3.55 months versus 13.6 months for those with a low number. In contrast, there was no significant association between the diffuse cytoplasmic pattern of LC3A staining and the survival of GC patients (Fig. 5E,F).


LC3A-positive "stone-like" structures predict an adverse prognosis of gastric cancer.

Liao W, Sun L, Wang C, Huang H, Liu J, Liao W, Shi M - Anat Rec (Hoboken) (2014)

Kaplan‐Meier analysis of the influence of the two patterns of LC3A staining in patients with GC at different stages. A: Postoperative recurrence of stages I–III disease was analyzed in relation to the number of LC3A‐positive SLS. Separate analyses were also carried out for patients from stage II (B) or stage III (C). D: Overall survival of stage IV patients according to the number of LC3A‐positive SLS. E: Postoperative recurrence of stages I–III disease in relation to diffuse cytoplasmic LC3A staining. F: Overall survival of stage IV GC patients in relation to diffuse cytoplasmic staining for LC3A.
© Copyright Policy - creativeCommonsBy-nc-nd
Related In: Results  -  Collection

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ar22895-fig-0005: Kaplan‐Meier analysis of the influence of the two patterns of LC3A staining in patients with GC at different stages. A: Postoperative recurrence of stages I–III disease was analyzed in relation to the number of LC3A‐positive SLS. Separate analyses were also carried out for patients from stage II (B) or stage III (C). D: Overall survival of stage IV patients according to the number of LC3A‐positive SLS. E: Postoperative recurrence of stages I–III disease in relation to diffuse cytoplasmic LC3A staining. F: Overall survival of stage IV GC patients in relation to diffuse cytoplasmic staining for LC3A.
Mentions: To evaluate the prognosis of the GC patients in relation to LC3A‐positive SLS and the diffuse cytoplasmic LC3A staining, Kaplan‐Meier survival analysis was performed. This showed that LC3A‐positive SLS were associated with an increased risk of postoperative recurrence in stages I–III (P < 0.001; HR = 0.205). The median time to recurrence was 12 months in stages I–III patients with a high number of LC3A‐positive SLS versus 40 months in those with a low number (Fig. 5A). Stratified analysis of postoperative recurrence was also performed to assess the influence of LC3A‐positive SLS in stage II patients (Fig. 5B) and stage III patients (Fig. 5C). The results indicated that LC3A‐positive SLS predicted postoperative recurrence in both stage II (P < 0.001; HR = 0.025) and stage III (P < 0.001; HR = 0.067). Due to the limited number of stage I patients, stratified analysis of postoperative recurrence was not performed. In stage IV patients, a high number of LC3A‐positive SLS was associated with lower overall survival rate (P < 0.001; HR = 0.364) (Fig. 5D). The median survival time of stage IV patients with a high number of LC3A‐positive SLS was 3.55 months versus 13.6 months for those with a low number. In contrast, there was no significant association between the diffuse cytoplasmic pattern of LC3A staining and the survival of GC patients (Fig. 5E,F).

Bottom Line: Two distinct patterns of LC3A immunostaining (diffuse cytoplasmic expression and "stone-like" structures) were observed in GC tissues.In addition, a high number of LC3A-positive "stone-like" structures was closely associated with an increased risk of recurrence after radical resection of stages I-III cancer (P < 0.001; HR = 0.205) and was associated with a lower overall survival rate for stage IV cancer (P < 0.001; HR = 0.364).Taken together, our data demonstrate that LC3A-positive "stone-like" structures can be used as an independent biomarker for an adverse prognosis of GC, suggesting that "stone-like" structures are correlated with the malignancy of this disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Show MeSH
Related in: MedlinePlus