LC3A-positive "stone-like" structures predict an adverse prognosis of gastric cancer.
Bottom Line: Two distinct patterns of LC3A immunostaining (diffuse cytoplasmic expression and "stone-like" structures) were observed in GC tissues.In addition, a high number of LC3A-positive "stone-like" structures was closely associated with an increased risk of recurrence after radical resection of stages I-III cancer (P < 0.001; HR = 0.205) and was associated with a lower overall survival rate for stage IV cancer (P < 0.001; HR = 0.364).Taken together, our data demonstrate that LC3A-positive "stone-like" structures can be used as an independent biomarker for an adverse prognosis of GC, suggesting that "stone-like" structures are correlated with the malignancy of this disease.
Affiliation: Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.Show MeSH
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Mentions: We also examined the association between the two patterns of LC3A expression and tumor type according to the classification of Lauren, finding that LC3A‐positive SLS numbers varied between tumor types. Diffuse tumors had more LC3A‐positive SLS than the intestinal type (P = 0.038) (Fig. 4A), but there was no significant difference for these two types as compared with mixed tumors. In contrast, there was no significant difference among diffuse, intestinal, and mixed tumors with respect to diffuse cytoplasmic staining for LC3A (Fig. 4B). Because tumor stage was also associated with postoperative recurrence (P < 0.001) (Fig. 4C), we investigated the relationship between LC3A‐positive SLS and the disease stage. The number of LC3A‐positive SLS was compared among patients in stages I–IV, revealing a higher number of these structures in more advanced tumors (P < 0.001) (Fig. 4D). In contrast, tumor stage showed no significant relationship with the diffuse cytoplasmic pattern of LC3A staining (Fig. 4E).
Affiliation: Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.