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LC3A-positive "stone-like" structures predict an adverse prognosis of gastric cancer.

Liao W, Sun L, Wang C, Huang H, Liu J, Liao W, Shi M - Anat Rec (Hoboken) (2014)

Bottom Line: Two distinct patterns of LC3A immunostaining (diffuse cytoplasmic expression and "stone-like" structures) were observed in GC tissues.In addition, a high number of LC3A-positive "stone-like" structures was closely associated with an increased risk of recurrence after radical resection of stages I-III cancer (P < 0.001; HR = 0.205) and was associated with a lower overall survival rate for stage IV cancer (P < 0.001; HR = 0.364).Taken together, our data demonstrate that LC3A-positive "stone-like" structures can be used as an independent biomarker for an adverse prognosis of GC, suggesting that "stone-like" structures are correlated with the malignancy of this disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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Association between the pattern of LC3A expression and tumor type or stage. A: Comparison of LC3A‐positive SLS with tumor type reveals a higher number of these structures in diffuse tumors than in the intestinal type of tumor (intestinal: n = 93, diffuse: n = 67, mixed: n = 28) (*diffuse vs. intestinal). B: Comparison of the diffuse cytoplasmic pattern of LC3A staining between tumor types. C: Relationship between tumor stage and disease‐free survival. D: Comparison of the number of LC3A‐positive SLS between tumor stages: a higher number of SLS is associated with a more advanced stage. E: Comparison of the diffuse cytoplasmic pattern of LC3A staining between tumor stages. The results are mean ± SE, ns: no significance, *P < 0.05, **P < 0.001.
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ar22895-fig-0004: Association between the pattern of LC3A expression and tumor type or stage. A: Comparison of LC3A‐positive SLS with tumor type reveals a higher number of these structures in diffuse tumors than in the intestinal type of tumor (intestinal: n = 93, diffuse: n = 67, mixed: n = 28) (*diffuse vs. intestinal). B: Comparison of the diffuse cytoplasmic pattern of LC3A staining between tumor types. C: Relationship between tumor stage and disease‐free survival. D: Comparison of the number of LC3A‐positive SLS between tumor stages: a higher number of SLS is associated with a more advanced stage. E: Comparison of the diffuse cytoplasmic pattern of LC3A staining between tumor stages. The results are mean ± SE, ns: no significance, *P < 0.05, **P < 0.001.

Mentions: We also examined the association between the two patterns of LC3A expression and tumor type according to the classification of Lauren, finding that LC3A‐positive SLS numbers varied between tumor types. Diffuse tumors had more LC3A‐positive SLS than the intestinal type (P = 0.038) (Fig. 4A), but there was no significant difference for these two types as compared with mixed tumors. In contrast, there was no significant difference among diffuse, intestinal, and mixed tumors with respect to diffuse cytoplasmic staining for LC3A (Fig. 4B). Because tumor stage was also associated with postoperative recurrence (P < 0.001) (Fig. 4C), we investigated the relationship between LC3A‐positive SLS and the disease stage. The number of LC3A‐positive SLS was compared among patients in stages I–IV, revealing a higher number of these structures in more advanced tumors (P < 0.001) (Fig. 4D). In contrast, tumor stage showed no significant relationship with the diffuse cytoplasmic pattern of LC3A staining (Fig. 4E).


LC3A-positive "stone-like" structures predict an adverse prognosis of gastric cancer.

Liao W, Sun L, Wang C, Huang H, Liu J, Liao W, Shi M - Anat Rec (Hoboken) (2014)

Association between the pattern of LC3A expression and tumor type or stage. A: Comparison of LC3A‐positive SLS with tumor type reveals a higher number of these structures in diffuse tumors than in the intestinal type of tumor (intestinal: n = 93, diffuse: n = 67, mixed: n = 28) (*diffuse vs. intestinal). B: Comparison of the diffuse cytoplasmic pattern of LC3A staining between tumor types. C: Relationship between tumor stage and disease‐free survival. D: Comparison of the number of LC3A‐positive SLS between tumor stages: a higher number of SLS is associated with a more advanced stage. E: Comparison of the diffuse cytoplasmic pattern of LC3A staining between tumor stages. The results are mean ± SE, ns: no significance, *P < 0.05, **P < 0.001.
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ar22895-fig-0004: Association between the pattern of LC3A expression and tumor type or stage. A: Comparison of LC3A‐positive SLS with tumor type reveals a higher number of these structures in diffuse tumors than in the intestinal type of tumor (intestinal: n = 93, diffuse: n = 67, mixed: n = 28) (*diffuse vs. intestinal). B: Comparison of the diffuse cytoplasmic pattern of LC3A staining between tumor types. C: Relationship between tumor stage and disease‐free survival. D: Comparison of the number of LC3A‐positive SLS between tumor stages: a higher number of SLS is associated with a more advanced stage. E: Comparison of the diffuse cytoplasmic pattern of LC3A staining between tumor stages. The results are mean ± SE, ns: no significance, *P < 0.05, **P < 0.001.
Mentions: We also examined the association between the two patterns of LC3A expression and tumor type according to the classification of Lauren, finding that LC3A‐positive SLS numbers varied between tumor types. Diffuse tumors had more LC3A‐positive SLS than the intestinal type (P = 0.038) (Fig. 4A), but there was no significant difference for these two types as compared with mixed tumors. In contrast, there was no significant difference among diffuse, intestinal, and mixed tumors with respect to diffuse cytoplasmic staining for LC3A (Fig. 4B). Because tumor stage was also associated with postoperative recurrence (P < 0.001) (Fig. 4C), we investigated the relationship between LC3A‐positive SLS and the disease stage. The number of LC3A‐positive SLS was compared among patients in stages I–IV, revealing a higher number of these structures in more advanced tumors (P < 0.001) (Fig. 4D). In contrast, tumor stage showed no significant relationship with the diffuse cytoplasmic pattern of LC3A staining (Fig. 4E).

Bottom Line: Two distinct patterns of LC3A immunostaining (diffuse cytoplasmic expression and "stone-like" structures) were observed in GC tissues.In addition, a high number of LC3A-positive "stone-like" structures was closely associated with an increased risk of recurrence after radical resection of stages I-III cancer (P < 0.001; HR = 0.205) and was associated with a lower overall survival rate for stage IV cancer (P < 0.001; HR = 0.364).Taken together, our data demonstrate that LC3A-positive "stone-like" structures can be used as an independent biomarker for an adverse prognosis of GC, suggesting that "stone-like" structures are correlated with the malignancy of this disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Show MeSH
Related in: MedlinePlus