LC3A-positive "stone-like" structures predict an adverse prognosis of gastric cancer.
Bottom Line: Two distinct patterns of LC3A immunostaining (diffuse cytoplasmic expression and "stone-like" structures) were observed in GC tissues.In addition, a high number of LC3A-positive "stone-like" structures was closely associated with an increased risk of recurrence after radical resection of stages I-III cancer (P < 0.001; HR = 0.205) and was associated with a lower overall survival rate for stage IV cancer (P < 0.001; HR = 0.364).Taken together, our data demonstrate that LC3A-positive "stone-like" structures can be used as an independent biomarker for an adverse prognosis of GC, suggesting that "stone-like" structures are correlated with the malignancy of this disease.
Affiliation: Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.Show MeSH
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Mentions: LC3A‐positive SLS were observed only in cancer tissues. Figure 3 shows that SLS in different types of GC. These structures were large, spheroidal, densely stained dark brown or black, and were typically enclosed within cytoplasmic vacuoles. The number of LC3A‐positive SLS per section ranged from 0 to 32 (the 67th percentile was 3), and 62 of the 188 tumors were in the high LC3A‐positive SLS group.
Affiliation: Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.