LC3A-positive "stone-like" structures predict an adverse prognosis of gastric cancer.
Bottom Line: Two distinct patterns of LC3A immunostaining (diffuse cytoplasmic expression and "stone-like" structures) were observed in GC tissues.In addition, a high number of LC3A-positive "stone-like" structures was closely associated with an increased risk of recurrence after radical resection of stages I-III cancer (P < 0.001; HR = 0.205) and was associated with a lower overall survival rate for stage IV cancer (P < 0.001; HR = 0.364).Taken together, our data demonstrate that LC3A-positive "stone-like" structures can be used as an independent biomarker for an adverse prognosis of GC, suggesting that "stone-like" structures are correlated with the malignancy of this disease.
Affiliation: Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.Show MeSH
Related in: MedlinePlus
Mentions: The specificity of the MAP1LC3A antibody was validated by western blot. The two bands corresponded to the LC3A‐I (cytosolic 16 kDa) and LC3A‐II (membrane‐bound 14 kDa) forms (Fig. 1).
Affiliation: Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.