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LC3A-positive "stone-like" structures predict an adverse prognosis of gastric cancer.

Liao W, Sun L, Wang C, Huang H, Liu J, Liao W, Shi M - Anat Rec (Hoboken) (2014)

Bottom Line: Two distinct patterns of LC3A immunostaining (diffuse cytoplasmic expression and "stone-like" structures) were observed in GC tissues.In addition, a high number of LC3A-positive "stone-like" structures was closely associated with an increased risk of recurrence after radical resection of stages I-III cancer (P < 0.001; HR = 0.205) and was associated with a lower overall survival rate for stage IV cancer (P < 0.001; HR = 0.364).Taken together, our data demonstrate that LC3A-positive "stone-like" structures can be used as an independent biomarker for an adverse prognosis of GC, suggesting that "stone-like" structures are correlated with the malignancy of this disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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LC3A antibody qualification by western blot analysis using mouse liver extracts. MW, molecular weight marker showing 17 kDa band.
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ar22895-fig-0001: LC3A antibody qualification by western blot analysis using mouse liver extracts. MW, molecular weight marker showing 17 kDa band.

Mentions: The specificity of the MAP1LC3A antibody was validated by western blot. The two bands corresponded to the LC3A‐I (cytosolic 16 kDa) and LC3A‐II (membrane‐bound 14 kDa) forms (Fig. 1).


LC3A-positive "stone-like" structures predict an adverse prognosis of gastric cancer.

Liao W, Sun L, Wang C, Huang H, Liu J, Liao W, Shi M - Anat Rec (Hoboken) (2014)

LC3A antibody qualification by western blot analysis using mouse liver extracts. MW, molecular weight marker showing 17 kDa band.
© Copyright Policy - creativeCommonsBy-nc-nd
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4279981&req=5

ar22895-fig-0001: LC3A antibody qualification by western blot analysis using mouse liver extracts. MW, molecular weight marker showing 17 kDa band.
Mentions: The specificity of the MAP1LC3A antibody was validated by western blot. The two bands corresponded to the LC3A‐I (cytosolic 16 kDa) and LC3A‐II (membrane‐bound 14 kDa) forms (Fig. 1).

Bottom Line: Two distinct patterns of LC3A immunostaining (diffuse cytoplasmic expression and "stone-like" structures) were observed in GC tissues.In addition, a high number of LC3A-positive "stone-like" structures was closely associated with an increased risk of recurrence after radical resection of stages I-III cancer (P < 0.001; HR = 0.205) and was associated with a lower overall survival rate for stage IV cancer (P < 0.001; HR = 0.364).Taken together, our data demonstrate that LC3A-positive "stone-like" structures can be used as an independent biomarker for an adverse prognosis of GC, suggesting that "stone-like" structures are correlated with the malignancy of this disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Show MeSH
Related in: MedlinePlus