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Combination of anxiety and depression is associated with an increased headache frequency in migraineurs: a population-based study.

Oh K, Cho SJ, Chung YK, Kim JM, Chu MK - BMC Neurol (2014)

Bottom Line: Of the 2,762 participants who completed the interview, 147 subjects (5.4%) were classified as having a migraine during the previous year.Combination of anxiety and depression was associated with an increased headache frequency.Anxiety was associated with exacerbation of headache intensity.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Korea University Guro Hospital, Korea University School of Medicine, Seoul, Korea. ohkm07@gmail.com.

ABSTRACT

Background: Although anxiety and depression have been classified as distinct traits of affective disorders, previous studies have reported their co-occurrence in subjects with migraine. However, few reports are available on the clinical implications of this comorbidity. This study is to assess the comorbidity of anxiety and depression in subjects with migraine and its clinical implications in a population-based sample from Korea.

Methods: We selected Korean subjects aged 19-69 years by the stratified random sampling method, and evaluated them using a semi-structured interview, designed to identify headache type, anxiety, and depression. We used Goldberg Anxiety Scale questions and Patient Health Questionnnaire-9 for the diagnosis of anxiety and depression, respectively.

Results: Of the 2,762 participants who completed the interview, 147 subjects (5.4%) were classified as having a migraine during the previous year. Among these 147 subjects, 17 (11.6%) had anxiety and depression, 28 (19.0%) had anxiety alone, 9 (6.1%) had depression alone, and 93 (63.3%) had neither anxiety nor depression. Headache frequency per month was remarkably higher in subjects having migraine with anxiety and depression (median [25-75 percentile values], 8.0 [2.5-21.0]) than in those having migraine with anxiety alone (2.0 [1.0-5.0], p = 0.003), migraine with depression alone (1.0 [0.3-4.0], p = 0.001), and migraine without anxiety or depression (1.0 [0.3-3.0], p < 0.001). The migraine with anxiety alone (7.0 [6.0-8.0], p = 0.011) group and migraine with anxiety and depression (7.0 [5.0-9.0], p = 0.018) group showed higher Visual Analogue Scale scores for pain intensity compare to migraine without anxiety or depression (6.0 [5.0-7.0]) group.

Conclusions: Approximately 1/3 of migraineurs with anxiety had depression and 2/3 of migraineurs with depression had anxiety. Combination of anxiety and depression was associated with an increased headache frequency. Anxiety was associated with exacerbation of headache intensity.

No MeSH data available.


Related in: MedlinePlus

Venn diagram for distribution of subjects with anxiety, depression and migraine.
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Fig2: Venn diagram for distribution of subjects with anxiety, depression and migraine.

Mentions: There was considerable overlap between anxiety and depression among subjects with migraine. Of the 147 subjects with migraine, 28 (19.0%) had anxiety alone, 9 (6.1%) had depression alone, and 17 (11.6%) had anxiety and depression. The remaining 93 (63.3%) had neither anxiety nor depression (Figure 2). The prevalence of anxiety in subjects with migraine (30.1%) was higher than that in subjects without migraine (8.8%, OR = 4.5, 95% CI 3.1–6.5); this pattern was consistent even after adjusting for sociodemographic variables (age, gender, educational level, and size of residential area) and depression (OR = 3.0, 95% CI = 2.0-4.7). The prevalence of depression in subjects with migraine (17.7%) was higher than that in subjects without migraine (3.8%, OR = 5.4, 95% CI 3.4–8.7); this pattern was consistent even after adjusting for sociodemographic variables and anxiety (OR = 2.7, 95% CI = 1.6-4.7).Figure 2


Combination of anxiety and depression is associated with an increased headache frequency in migraineurs: a population-based study.

Oh K, Cho SJ, Chung YK, Kim JM, Chu MK - BMC Neurol (2014)

Venn diagram for distribution of subjects with anxiety, depression and migraine.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4279894&req=5

Fig2: Venn diagram for distribution of subjects with anxiety, depression and migraine.
Mentions: There was considerable overlap between anxiety and depression among subjects with migraine. Of the 147 subjects with migraine, 28 (19.0%) had anxiety alone, 9 (6.1%) had depression alone, and 17 (11.6%) had anxiety and depression. The remaining 93 (63.3%) had neither anxiety nor depression (Figure 2). The prevalence of anxiety in subjects with migraine (30.1%) was higher than that in subjects without migraine (8.8%, OR = 4.5, 95% CI 3.1–6.5); this pattern was consistent even after adjusting for sociodemographic variables (age, gender, educational level, and size of residential area) and depression (OR = 3.0, 95% CI = 2.0-4.7). The prevalence of depression in subjects with migraine (17.7%) was higher than that in subjects without migraine (3.8%, OR = 5.4, 95% CI 3.4–8.7); this pattern was consistent even after adjusting for sociodemographic variables and anxiety (OR = 2.7, 95% CI = 1.6-4.7).Figure 2

Bottom Line: Of the 2,762 participants who completed the interview, 147 subjects (5.4%) were classified as having a migraine during the previous year.Combination of anxiety and depression was associated with an increased headache frequency.Anxiety was associated with exacerbation of headache intensity.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Korea University Guro Hospital, Korea University School of Medicine, Seoul, Korea. ohkm07@gmail.com.

ABSTRACT

Background: Although anxiety and depression have been classified as distinct traits of affective disorders, previous studies have reported their co-occurrence in subjects with migraine. However, few reports are available on the clinical implications of this comorbidity. This study is to assess the comorbidity of anxiety and depression in subjects with migraine and its clinical implications in a population-based sample from Korea.

Methods: We selected Korean subjects aged 19-69 years by the stratified random sampling method, and evaluated them using a semi-structured interview, designed to identify headache type, anxiety, and depression. We used Goldberg Anxiety Scale questions and Patient Health Questionnnaire-9 for the diagnosis of anxiety and depression, respectively.

Results: Of the 2,762 participants who completed the interview, 147 subjects (5.4%) were classified as having a migraine during the previous year. Among these 147 subjects, 17 (11.6%) had anxiety and depression, 28 (19.0%) had anxiety alone, 9 (6.1%) had depression alone, and 93 (63.3%) had neither anxiety nor depression. Headache frequency per month was remarkably higher in subjects having migraine with anxiety and depression (median [25-75 percentile values], 8.0 [2.5-21.0]) than in those having migraine with anxiety alone (2.0 [1.0-5.0], p = 0.003), migraine with depression alone (1.0 [0.3-4.0], p = 0.001), and migraine without anxiety or depression (1.0 [0.3-3.0], p < 0.001). The migraine with anxiety alone (7.0 [6.0-8.0], p = 0.011) group and migraine with anxiety and depression (7.0 [5.0-9.0], p = 0.018) group showed higher Visual Analogue Scale scores for pain intensity compare to migraine without anxiety or depression (6.0 [5.0-7.0]) group.

Conclusions: Approximately 1/3 of migraineurs with anxiety had depression and 2/3 of migraineurs with depression had anxiety. Combination of anxiety and depression was associated with an increased headache frequency. Anxiety was associated with exacerbation of headache intensity.

No MeSH data available.


Related in: MedlinePlus