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Metastasis of laryngeal squamous cell carcinoma to bilateral thigh muscles.

Lucas Z, Mukherjee A, Chia S, Veytsman I - Case Rep Oncol Med (2014)

Bottom Line: Conclusions.Distant metastasis such as skeletal metastasis portends a poor prognosis.Further studies are required to determine the best course of treatment in these patients.

View Article: PubMed Central - PubMed

Affiliation: Division of Hematology and Oncology, Washington Cancer Institute, Washington, DC 20010, USA ; MedStar Washington Hospital Center, 110 Irving Street, Washington, DC 20010, USA.

ABSTRACT
Importance. Laryngeal cancer infrequently results in distant metastases, but metastasis to skeletal muscle is extremely uncommon. Observations. A 55-year-old male presenting with progressive dyspnea and hoarseness was found to have Stage IVA T4aN2cM0 laryngeal cancer and eventually underwent total laryngectomy. Before the patient could be started on adjuvant chemoradiation, the patient developed masses on both thighs. Biopsy revealed metastatic squamous cell carcinoma consistent with the primary laryngeal cancer. He was offered palliative chemotherapy; however, he developed new soft tissue masses to the left of his stoma and in the prevertebral area one week later. He also had new cervical and supraclavicular nodes and a pathological compression fracture of L3. Patient died within 4 months of diagnosis. Conclusions. Distant metastasis such as skeletal metastasis portends a poor prognosis. Further studies are required to determine the best course of treatment in these patients.

No MeSH data available.


Related in: MedlinePlus

Supraglottic-level CT showing airway narrowed by glottis mass (1) and lymph node metastasis (2).
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fig1: Supraglottic-level CT showing airway narrowed by glottis mass (1) and lymph node metastasis (2).

Mentions: A 55-year-old African-American male with significant smoking and drinking history presented with progressive dyspnea and hoarseness over five months. He had stridor and multiple enlarged right lymph nodes (level II and level III) on exam. Flexible laryngoscopy revealed an obstructing mass of the glottis; however the vocal fold mobility could not be assessed. Computed tomography (CT) image of the neck revealed an extensive transglottic mass with significant laryngeal narrowing and cartilage invasion as well as multiple enlarged right neck and retropharyngeal lymph nodes (Figure 1). Urgent tracheostomy was performed due to airway compromise. Direct laryngoscopy revealed a transglottic mass that originated at the level of the vocal folds bilaterally, extending to the subglottic region approximately 1 cm past the true vocal cords. The inferior extent of the transglottic mass was difficult to discern. Multiple biopsies were performed and pathology revealed poorly differentiated squamous cell carcinoma. Chest CT imaging revealed no distant metastases.


Metastasis of laryngeal squamous cell carcinoma to bilateral thigh muscles.

Lucas Z, Mukherjee A, Chia S, Veytsman I - Case Rep Oncol Med (2014)

Supraglottic-level CT showing airway narrowed by glottis mass (1) and lymph node metastasis (2).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4279822&req=5

fig1: Supraglottic-level CT showing airway narrowed by glottis mass (1) and lymph node metastasis (2).
Mentions: A 55-year-old African-American male with significant smoking and drinking history presented with progressive dyspnea and hoarseness over five months. He had stridor and multiple enlarged right lymph nodes (level II and level III) on exam. Flexible laryngoscopy revealed an obstructing mass of the glottis; however the vocal fold mobility could not be assessed. Computed tomography (CT) image of the neck revealed an extensive transglottic mass with significant laryngeal narrowing and cartilage invasion as well as multiple enlarged right neck and retropharyngeal lymph nodes (Figure 1). Urgent tracheostomy was performed due to airway compromise. Direct laryngoscopy revealed a transglottic mass that originated at the level of the vocal folds bilaterally, extending to the subglottic region approximately 1 cm past the true vocal cords. The inferior extent of the transglottic mass was difficult to discern. Multiple biopsies were performed and pathology revealed poorly differentiated squamous cell carcinoma. Chest CT imaging revealed no distant metastases.

Bottom Line: Conclusions.Distant metastasis such as skeletal metastasis portends a poor prognosis.Further studies are required to determine the best course of treatment in these patients.

View Article: PubMed Central - PubMed

Affiliation: Division of Hematology and Oncology, Washington Cancer Institute, Washington, DC 20010, USA ; MedStar Washington Hospital Center, 110 Irving Street, Washington, DC 20010, USA.

ABSTRACT
Importance. Laryngeal cancer infrequently results in distant metastases, but metastasis to skeletal muscle is extremely uncommon. Observations. A 55-year-old male presenting with progressive dyspnea and hoarseness was found to have Stage IVA T4aN2cM0 laryngeal cancer and eventually underwent total laryngectomy. Before the patient could be started on adjuvant chemoradiation, the patient developed masses on both thighs. Biopsy revealed metastatic squamous cell carcinoma consistent with the primary laryngeal cancer. He was offered palliative chemotherapy; however, he developed new soft tissue masses to the left of his stoma and in the prevertebral area one week later. He also had new cervical and supraclavicular nodes and a pathological compression fracture of L3. Patient died within 4 months of diagnosis. Conclusions. Distant metastasis such as skeletal metastasis portends a poor prognosis. Further studies are required to determine the best course of treatment in these patients.

No MeSH data available.


Related in: MedlinePlus