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Electroacupuncture stimulation at sub-specific acupoint and non-acupoint induced distinct brain glucose metabolism change in migraineurs: a PET-CT study.

Yang M, Yang J, Zeng F, Liu P, Lai Z, Deng S, Fang L, Song W, Xie H, Liang F - J Transl Med (2014)

Bottom Line: Positron emission tomography with computed tomography (PET-CT) was used to identify differences in brain glucose metabolism between groups.In the AG, brain glucose metabolism increase compared with the MG was observed in the middle frontal gyrus, postcentral gyrus, the precuneus, parahippocampus, cerebellum and middle cingulate cortex (MCC), and decrease were observed in the left hemisphere of Middle Temporal Cortex (MTC).In the SAG, compared with MG, glucose metabolism increased in the poster cingulate cortex (PCC), insula, inferior temporal gyrus, MTC, superior temporal gyrus, postcentral gyrus, fusiform, inferior parietal lobe, superior parietal lobe, supramarginal gyrus, middle occipital lobe, angular and precuneus; while, decreased in cerebellum, parahippocampus.The pattern of brain glucose metabolism change in acupoint is pertinent and targeted, while in non-acupoint that was disordered and randomized.

View Article: PubMed Central - PubMed

Affiliation: Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China. mingxiaoyang@hotmail.com.

ABSTRACT

Background: Acupuncture has analgesic effect to most pain conditions. Many neuroimaging studies were conducted to explore acupoint specificity in pain and other condition, but till now there is still discrepancy. Based on our previous finding, this study investigated the brain metabolism changes of acupuncture analgesia induced by sub-specific acupoint and non-acupoint stimulation.

Methods: 30 migraineurs were included and randomly assigned to 3 groups: Acupuncture Group (AG), Sham Acupuncture Group (SAG) and Migraine Group (MG). In AG, a combination sub-specific points of Shaoyang meridians, Luxi (TE19), San Yangluo (TE8), and Xi Yangguan (GB33) has been stimulated with electroacupuncture, while non-acupoints for SAG were used and MG received no treatment. Positron emission tomography with computed tomography (PET-CT) was used to identify differences in brain glucose metabolism between groups.

Results: In the AG, brain glucose metabolism increase compared with the MG was observed in the middle frontal gyrus, postcentral gyrus, the precuneus, parahippocampus, cerebellum and middle cingulate cortex (MCC), and decrease were observed in the left hemisphere of Middle Temporal Cortex (MTC).In the SAG, compared with MG, glucose metabolism increased in the poster cingulate cortex (PCC), insula, inferior temporal gyrus, MTC, superior temporal gyrus, postcentral gyrus, fusiform, inferior parietal lobe, superior parietal lobe, supramarginal gyrus, middle occipital lobe, angular and precuneus; while, decreased in cerebellum, parahippocampus.

Conclusions: Acupuncture stimulation at both sub-specific acupoint and non-acupoint yields ameliorating effect to migraine pain, but with evidently differed central mechanism as measured by PET-CT. The pattern of brain glucose metabolism change in acupoint is pertinent and targeted, while in non-acupoint that was disordered and randomized. These finding may provide new perspectives into the validation of acupoint specificity, optimizing acupuncture analgesia and revealing central mechanism of acupuncture analgesia by neuroimaging measurement.

Trial registration: This trial was registered in the Chinese Clinical Trial Registry, with registration no. ChiCTR-TRC-11001813.

No MeSH data available.


Related in: MedlinePlus

Location of points in AG and SAG.
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Fig1: Location of points in AG and SAG.

Mentions: Included participants were averagely assigned to either one of the three groups by means of simple randomization. The acupoint combination for the AG included three sub-specific acupoints on Shaoyang meridians, Luxi (TE19), San Yangluo (TE8), and Xi Yangguan (GB33). Non-acupoints applied in the SAG were predefined and utilized in previous studies of our team [21]. The locations of these non-acupoints were described as follows: (1) Sham-point 1:The medial side of the arm at the anterior border of the insertion of the deltoid muscle at the junction of the deltoid and biceps muscles; (2) Sham-point 2:The edge of the tibia ,1–2 cm lateral and horizontal to the Zusanli, ST36; (3) Sham-point 3: On the ulnar side of the arm, half way between the epicondylus medialis of the humerus and the ulnar side of the wrist. These three points were sited distant to the traditionally recognized acupoints or meridians lines. Illustrations of these points were showed in Figure 1. Only points on the left side of the body were used in the experiment.Figure 1


Electroacupuncture stimulation at sub-specific acupoint and non-acupoint induced distinct brain glucose metabolism change in migraineurs: a PET-CT study.

Yang M, Yang J, Zeng F, Liu P, Lai Z, Deng S, Fang L, Song W, Xie H, Liang F - J Transl Med (2014)

Location of points in AG and SAG.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4279794&req=5

Fig1: Location of points in AG and SAG.
Mentions: Included participants were averagely assigned to either one of the three groups by means of simple randomization. The acupoint combination for the AG included three sub-specific acupoints on Shaoyang meridians, Luxi (TE19), San Yangluo (TE8), and Xi Yangguan (GB33). Non-acupoints applied in the SAG were predefined and utilized in previous studies of our team [21]. The locations of these non-acupoints were described as follows: (1) Sham-point 1:The medial side of the arm at the anterior border of the insertion of the deltoid muscle at the junction of the deltoid and biceps muscles; (2) Sham-point 2:The edge of the tibia ,1–2 cm lateral and horizontal to the Zusanli, ST36; (3) Sham-point 3: On the ulnar side of the arm, half way between the epicondylus medialis of the humerus and the ulnar side of the wrist. These three points were sited distant to the traditionally recognized acupoints or meridians lines. Illustrations of these points were showed in Figure 1. Only points on the left side of the body were used in the experiment.Figure 1

Bottom Line: Positron emission tomography with computed tomography (PET-CT) was used to identify differences in brain glucose metabolism between groups.In the AG, brain glucose metabolism increase compared with the MG was observed in the middle frontal gyrus, postcentral gyrus, the precuneus, parahippocampus, cerebellum and middle cingulate cortex (MCC), and decrease were observed in the left hemisphere of Middle Temporal Cortex (MTC).In the SAG, compared with MG, glucose metabolism increased in the poster cingulate cortex (PCC), insula, inferior temporal gyrus, MTC, superior temporal gyrus, postcentral gyrus, fusiform, inferior parietal lobe, superior parietal lobe, supramarginal gyrus, middle occipital lobe, angular and precuneus; while, decreased in cerebellum, parahippocampus.The pattern of brain glucose metabolism change in acupoint is pertinent and targeted, while in non-acupoint that was disordered and randomized.

View Article: PubMed Central - PubMed

Affiliation: Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China. mingxiaoyang@hotmail.com.

ABSTRACT

Background: Acupuncture has analgesic effect to most pain conditions. Many neuroimaging studies were conducted to explore acupoint specificity in pain and other condition, but till now there is still discrepancy. Based on our previous finding, this study investigated the brain metabolism changes of acupuncture analgesia induced by sub-specific acupoint and non-acupoint stimulation.

Methods: 30 migraineurs were included and randomly assigned to 3 groups: Acupuncture Group (AG), Sham Acupuncture Group (SAG) and Migraine Group (MG). In AG, a combination sub-specific points of Shaoyang meridians, Luxi (TE19), San Yangluo (TE8), and Xi Yangguan (GB33) has been stimulated with electroacupuncture, while non-acupoints for SAG were used and MG received no treatment. Positron emission tomography with computed tomography (PET-CT) was used to identify differences in brain glucose metabolism between groups.

Results: In the AG, brain glucose metabolism increase compared with the MG was observed in the middle frontal gyrus, postcentral gyrus, the precuneus, parahippocampus, cerebellum and middle cingulate cortex (MCC), and decrease were observed in the left hemisphere of Middle Temporal Cortex (MTC).In the SAG, compared with MG, glucose metabolism increased in the poster cingulate cortex (PCC), insula, inferior temporal gyrus, MTC, superior temporal gyrus, postcentral gyrus, fusiform, inferior parietal lobe, superior parietal lobe, supramarginal gyrus, middle occipital lobe, angular and precuneus; while, decreased in cerebellum, parahippocampus.

Conclusions: Acupuncture stimulation at both sub-specific acupoint and non-acupoint yields ameliorating effect to migraine pain, but with evidently differed central mechanism as measured by PET-CT. The pattern of brain glucose metabolism change in acupoint is pertinent and targeted, while in non-acupoint that was disordered and randomized. These finding may provide new perspectives into the validation of acupoint specificity, optimizing acupuncture analgesia and revealing central mechanism of acupuncture analgesia by neuroimaging measurement.

Trial registration: This trial was registered in the Chinese Clinical Trial Registry, with registration no. ChiCTR-TRC-11001813.

No MeSH data available.


Related in: MedlinePlus