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The diversity of human papillomavirus infection among human immunodeficiency virus-infected women in Yunnan, China.

Zhang HY, Fei MD, Jiang Y, Fei QY, Qian H, Xu L, Jin YN, Jiang CQ, Li HX, Tiggelaar SM, Smith JS, Sahasrabuddhe VV, Qiao YL - Virol. J. (2014)

Bottom Line: Overall, the most common carcinogenic HPV types were HPV52 (7.3%), HPV58 (6.6%), HPV18 (6.3%), HPV16 (6.0%), and HPV33 (5.3%).Increasing age was an independent risk factor associated with presence of single carcinogenic HPV types (adjusted odds ratio: 1.04, 95%CI: 1.01-1.07, p = 0.012) but not with the presence of multiple carcinogenic types in the multivariable-adjusted models.As HIV-infected women continue to live longer on antiretroviral therapy in China, it will be increasingly important to screen for, and prevent, HPV-associated cervical cancer in this population, especially given the wide diversity and multiplicity of HPV genotypes.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynecology and Obstetrics, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China. 13888750195@163.com.

ABSTRACT

Background: Yunnan has one of the oldest and the most severe human immunodeficiency virus (HIV) epidemics in China. We conducted an observational study to evaluate the human papillomavirus (HPV) genotype distribution in relation to cervical neoplastic disease risk among HIV-infected women in Yunnan.

Methods: We screened 301 HIV-infected non-pregnant women in Mangshi prefecture in Yunnan province. All consenting participants underwent simultaneous and independent assessment by cervical cytology, colposcopy-histopathology, and HPV genotyping. Unadjusted and multivariable-adjusted multinomial logistic regression analysis was conducted to evaluate factors associated with single or multiple carcinogenic HPV genotypes.

Results: HPV genotypes were present in 43.5% (131/301) overall, and carcinogenic HPV genotypes were present in 37.5% (113/301) women. Among women with carcinogenic HPV genotypes, 80 (70.8% of 113) had a single carcinogenic HPV type, while 33 (29.2%) women had multiple (2 or more) carcinogenic HPV types. Overall, the most common carcinogenic HPV types were HPV52 (7.3%), HPV58 (6.6%), HPV18 (6.3%), HPV16 (6.0%), and HPV33 (5.3%). In women with cervical precancerous lesions (i.e., high-grade squamous intraepithelial lesions [HSIL] on cytology or cervical intraepithelial neoplasia grade 2 or worse [CIN2+] detected on colposcopy-histology), the most commonly detected genotypes were HPV16 (28.6%), HPV52 (25.0%), HPV58 (17.9%), HPV18 (10.7%) and HPV31 (10.7%). Increasing age was an independent risk factor associated with presence of single carcinogenic HPV types (adjusted odds ratio: 1.04, 95%CI: 1.01-1.07, p = 0.012) but not with the presence of multiple carcinogenic types in the multivariable-adjusted models.

Conclusions: As HIV-infected women continue to live longer on antiretroviral therapy in China, it will be increasingly important to screen for, and prevent, HPV-associated cervical cancer in this population, especially given the wide diversity and multiplicity of HPV genotypes.

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Prevalence of HPV infection by duration of receiving ART group among HIV-infected women in Yunnan, China. *p value for trend of univariate analysis was <0.05. HPV, Human Papillomavirus. Carcinogenic HPV includes HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68. Possibly carcinogenic HPV includes HPV 53, 66, 73 and 82. ART, Antiretroviral Therapy. With increasing duration on ART, p-value for trend for carcinogenic HPV and multiple carcinogenic HPV were 0.013 and 0.002, respectively.
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Fig3: Prevalence of HPV infection by duration of receiving ART group among HIV-infected women in Yunnan, China. *p value for trend of univariate analysis was <0.05. HPV, Human Papillomavirus. Carcinogenic HPV includes HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68. Possibly carcinogenic HPV includes HPV 53, 66, 73 and 82. ART, Antiretroviral Therapy. With increasing duration on ART, p-value for trend for carcinogenic HPV and multiple carcinogenic HPV were 0.013 and 0.002, respectively.

Mentions: Figure 3 presents HPV genotype groupings by duration (in months) on being on ART. Longer duration of being on ART was associated with lower detection of HPV infections. Statistically significant (p < 0.05) lower HPV detections associated with categories of longer duration on ART were observed for the groupings of carcinogenic HPV and multiple carcinogenic HPV genotypes.Figure 3


The diversity of human papillomavirus infection among human immunodeficiency virus-infected women in Yunnan, China.

Zhang HY, Fei MD, Jiang Y, Fei QY, Qian H, Xu L, Jin YN, Jiang CQ, Li HX, Tiggelaar SM, Smith JS, Sahasrabuddhe VV, Qiao YL - Virol. J. (2014)

Prevalence of HPV infection by duration of receiving ART group among HIV-infected women in Yunnan, China. *p value for trend of univariate analysis was <0.05. HPV, Human Papillomavirus. Carcinogenic HPV includes HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68. Possibly carcinogenic HPV includes HPV 53, 66, 73 and 82. ART, Antiretroviral Therapy. With increasing duration on ART, p-value for trend for carcinogenic HPV and multiple carcinogenic HPV were 0.013 and 0.002, respectively.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4279793&req=5

Fig3: Prevalence of HPV infection by duration of receiving ART group among HIV-infected women in Yunnan, China. *p value for trend of univariate analysis was <0.05. HPV, Human Papillomavirus. Carcinogenic HPV includes HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68. Possibly carcinogenic HPV includes HPV 53, 66, 73 and 82. ART, Antiretroviral Therapy. With increasing duration on ART, p-value for trend for carcinogenic HPV and multiple carcinogenic HPV were 0.013 and 0.002, respectively.
Mentions: Figure 3 presents HPV genotype groupings by duration (in months) on being on ART. Longer duration of being on ART was associated with lower detection of HPV infections. Statistically significant (p < 0.05) lower HPV detections associated with categories of longer duration on ART were observed for the groupings of carcinogenic HPV and multiple carcinogenic HPV genotypes.Figure 3

Bottom Line: Overall, the most common carcinogenic HPV types were HPV52 (7.3%), HPV58 (6.6%), HPV18 (6.3%), HPV16 (6.0%), and HPV33 (5.3%).Increasing age was an independent risk factor associated with presence of single carcinogenic HPV types (adjusted odds ratio: 1.04, 95%CI: 1.01-1.07, p = 0.012) but not with the presence of multiple carcinogenic types in the multivariable-adjusted models.As HIV-infected women continue to live longer on antiretroviral therapy in China, it will be increasingly important to screen for, and prevent, HPV-associated cervical cancer in this population, especially given the wide diversity and multiplicity of HPV genotypes.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynecology and Obstetrics, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China. 13888750195@163.com.

ABSTRACT

Background: Yunnan has one of the oldest and the most severe human immunodeficiency virus (HIV) epidemics in China. We conducted an observational study to evaluate the human papillomavirus (HPV) genotype distribution in relation to cervical neoplastic disease risk among HIV-infected women in Yunnan.

Methods: We screened 301 HIV-infected non-pregnant women in Mangshi prefecture in Yunnan province. All consenting participants underwent simultaneous and independent assessment by cervical cytology, colposcopy-histopathology, and HPV genotyping. Unadjusted and multivariable-adjusted multinomial logistic regression analysis was conducted to evaluate factors associated with single or multiple carcinogenic HPV genotypes.

Results: HPV genotypes were present in 43.5% (131/301) overall, and carcinogenic HPV genotypes were present in 37.5% (113/301) women. Among women with carcinogenic HPV genotypes, 80 (70.8% of 113) had a single carcinogenic HPV type, while 33 (29.2%) women had multiple (2 or more) carcinogenic HPV types. Overall, the most common carcinogenic HPV types were HPV52 (7.3%), HPV58 (6.6%), HPV18 (6.3%), HPV16 (6.0%), and HPV33 (5.3%). In women with cervical precancerous lesions (i.e., high-grade squamous intraepithelial lesions [HSIL] on cytology or cervical intraepithelial neoplasia grade 2 or worse [CIN2+] detected on colposcopy-histology), the most commonly detected genotypes were HPV16 (28.6%), HPV52 (25.0%), HPV58 (17.9%), HPV18 (10.7%) and HPV31 (10.7%). Increasing age was an independent risk factor associated with presence of single carcinogenic HPV types (adjusted odds ratio: 1.04, 95%CI: 1.01-1.07, p = 0.012) but not with the presence of multiple carcinogenic types in the multivariable-adjusted models.

Conclusions: As HIV-infected women continue to live longer on antiretroviral therapy in China, it will be increasingly important to screen for, and prevent, HPV-associated cervical cancer in this population, especially given the wide diversity and multiplicity of HPV genotypes.

Show MeSH
Related in: MedlinePlus