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Elevated Serum Thyroglobulin and Low Iodine Intake Are Associated with Nontoxic Nodular Goiter among Adults Living near the Eastern Mediterranean Coast.

Ovadia YS, Gefel D, Turkot S, Aharoni D, Fytlovich S, Troen AM - J Thyroid Res (2014)

Bottom Line: Conclusions.Elevated serum Tg values and low dietary iodine intake are associated with NNG among adult patients in Ashkelon District, Israel.Larger studies are needed in order to expand on these important initial findings.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine "C", Barzilai Medical Center Ashkelon, Hahistadrout Street 2, 7830604 Ashkelon, Israel ; Nutrition and Brain Health Laboratory, School of Nutritional Sciences, Institute of Biochemistry, Food Science and Nutrition, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, P.O. Box 12, 76100 Rehovot, Israel.

ABSTRACT
Background. Information about iodine intake is crucial for preventing thyroid diseases. Inadequate iodine intake can lead to thyroid diseases, including nontoxic nodular goiter (NNG). Objective. To estimate iodine intake and explore its correlation with thyroid diseases among Israeli adults living near the Mediterranean coast, where iodine-depleted desalinated water has become a major source of drinking water. Methods. Cross-sectional study of patients attending Barzilai Medical Center Ashkelon. Participants, who were classified as either NNG (n = 17), hypothyroidism (n = 14), or control (n = 31), provided serum thyroglobulin (Tg) and completed a semiquantitative iodine food frequency questionnaire. Results. Elevated serum Tg values (Tg > 60 ng/mL) were significantly more prevalent in the NNG group than in the other groups (29% versus 7% and 0% for hypothyroidism and controls, resp., P < 0.05). Mean estimated iodine intake was significantly lower in the NNG group (65 ± 30 μg/d) than in controls (115 ± 60 μg/d) (P < 0.05) with intermediate intake in the hypothyroid group (73 ± 38 μg/d). Conclusions. Elevated serum Tg values and low dietary iodine intake are associated with NNG among adult patients in Ashkelon District, Israel. Larger studies are needed in order to expand on these important initial findings.

No MeSH data available.


Related in: MedlinePlus

Medians of estimated dietary iodine intake and serum Tg by group. Numbers at the top of each column are median values. Tg: thyroglobulin; NNG: nontoxic nodular goiter; ng/mL: nanogram per milliliter; μg/d: microgram per day.
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fig2: Medians of estimated dietary iodine intake and serum Tg by group. Numbers at the top of each column are median values. Tg: thyroglobulin; NNG: nontoxic nodular goiter; ng/mL: nanogram per milliliter; μg/d: microgram per day.

Mentions: A comparison by group of detailed mean, median, range, and prevalence of elevated serum Tg, as well as estimated iodine intake by sIFFQ, is given in Table 2. Median estimated dietary iodine intake and serum Tg are shown by group in Figure 2.


Elevated Serum Thyroglobulin and Low Iodine Intake Are Associated with Nontoxic Nodular Goiter among Adults Living near the Eastern Mediterranean Coast.

Ovadia YS, Gefel D, Turkot S, Aharoni D, Fytlovich S, Troen AM - J Thyroid Res (2014)

Medians of estimated dietary iodine intake and serum Tg by group. Numbers at the top of each column are median values. Tg: thyroglobulin; NNG: nontoxic nodular goiter; ng/mL: nanogram per milliliter; μg/d: microgram per day.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4279788&req=5

fig2: Medians of estimated dietary iodine intake and serum Tg by group. Numbers at the top of each column are median values. Tg: thyroglobulin; NNG: nontoxic nodular goiter; ng/mL: nanogram per milliliter; μg/d: microgram per day.
Mentions: A comparison by group of detailed mean, median, range, and prevalence of elevated serum Tg, as well as estimated iodine intake by sIFFQ, is given in Table 2. Median estimated dietary iodine intake and serum Tg are shown by group in Figure 2.

Bottom Line: Conclusions.Elevated serum Tg values and low dietary iodine intake are associated with NNG among adult patients in Ashkelon District, Israel.Larger studies are needed in order to expand on these important initial findings.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine "C", Barzilai Medical Center Ashkelon, Hahistadrout Street 2, 7830604 Ashkelon, Israel ; Nutrition and Brain Health Laboratory, School of Nutritional Sciences, Institute of Biochemistry, Food Science and Nutrition, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, P.O. Box 12, 76100 Rehovot, Israel.

ABSTRACT
Background. Information about iodine intake is crucial for preventing thyroid diseases. Inadequate iodine intake can lead to thyroid diseases, including nontoxic nodular goiter (NNG). Objective. To estimate iodine intake and explore its correlation with thyroid diseases among Israeli adults living near the Mediterranean coast, where iodine-depleted desalinated water has become a major source of drinking water. Methods. Cross-sectional study of patients attending Barzilai Medical Center Ashkelon. Participants, who were classified as either NNG (n = 17), hypothyroidism (n = 14), or control (n = 31), provided serum thyroglobulin (Tg) and completed a semiquantitative iodine food frequency questionnaire. Results. Elevated serum Tg values (Tg > 60 ng/mL) were significantly more prevalent in the NNG group than in the other groups (29% versus 7% and 0% for hypothyroidism and controls, resp., P < 0.05). Mean estimated iodine intake was significantly lower in the NNG group (65 ± 30 μg/d) than in controls (115 ± 60 μg/d) (P < 0.05) with intermediate intake in the hypothyroid group (73 ± 38 μg/d). Conclusions. Elevated serum Tg values and low dietary iodine intake are associated with NNG among adult patients in Ashkelon District, Israel. Larger studies are needed in order to expand on these important initial findings.

No MeSH data available.


Related in: MedlinePlus