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Elevated Serum Thyroglobulin and Low Iodine Intake Are Associated with Nontoxic Nodular Goiter among Adults Living near the Eastern Mediterranean Coast.

Ovadia YS, Gefel D, Turkot S, Aharoni D, Fytlovich S, Troen AM - J Thyroid Res (2014)

Bottom Line: Conclusions.Elevated serum Tg values and low dietary iodine intake are associated with NNG among adult patients in Ashkelon District, Israel.Larger studies are needed in order to expand on these important initial findings.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine "C", Barzilai Medical Center Ashkelon, Hahistadrout Street 2, 7830604 Ashkelon, Israel ; Nutrition and Brain Health Laboratory, School of Nutritional Sciences, Institute of Biochemistry, Food Science and Nutrition, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, P.O. Box 12, 76100 Rehovot, Israel.

ABSTRACT
Background. Information about iodine intake is crucial for preventing thyroid diseases. Inadequate iodine intake can lead to thyroid diseases, including nontoxic nodular goiter (NNG). Objective. To estimate iodine intake and explore its correlation with thyroid diseases among Israeli adults living near the Mediterranean coast, where iodine-depleted desalinated water has become a major source of drinking water. Methods. Cross-sectional study of patients attending Barzilai Medical Center Ashkelon. Participants, who were classified as either NNG (n = 17), hypothyroidism (n = 14), or control (n = 31), provided serum thyroglobulin (Tg) and completed a semiquantitative iodine food frequency questionnaire. Results. Elevated serum Tg values (Tg > 60 ng/mL) were significantly more prevalent in the NNG group than in the other groups (29% versus 7% and 0% for hypothyroidism and controls, resp., P < 0.05). Mean estimated iodine intake was significantly lower in the NNG group (65 ± 30 μg/d) than in controls (115 ± 60 μg/d) (P < 0.05) with intermediate intake in the hypothyroid group (73 ± 38 μg/d). Conclusions. Elevated serum Tg values and low dietary iodine intake are associated with NNG among adult patients in Ashkelon District, Israel. Larger studies are needed in order to expand on these important initial findings.

No MeSH data available.


Related in: MedlinePlus

Map of Israel southern coastal area, showing Ashkelon District territory and location (reproduced with permission from The Israel Central Bureau of Statistics: http://gis.cbs.gov.il/benyam/).
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fig1: Map of Israel southern coastal area, showing Ashkelon District territory and location (reproduced with permission from The Israel Central Bureau of Statistics: http://gis.cbs.gov.il/benyam/).

Mentions: In this cross-sectional study, iodine status was assessed in a convenience sample of volunteers living in the Ashkelon District, Israel, who were prospectively recruited at Barzilai Medical Center in Ashkelon (BMCA). The Ashkelon District and city, where the BMCA is located, are shown in the accompanying map (Figure 1). Volunteers were enrolled over a period of 22 months (from March 2012 to January 2014).


Elevated Serum Thyroglobulin and Low Iodine Intake Are Associated with Nontoxic Nodular Goiter among Adults Living near the Eastern Mediterranean Coast.

Ovadia YS, Gefel D, Turkot S, Aharoni D, Fytlovich S, Troen AM - J Thyroid Res (2014)

Map of Israel southern coastal area, showing Ashkelon District territory and location (reproduced with permission from The Israel Central Bureau of Statistics: http://gis.cbs.gov.il/benyam/).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4279788&req=5

fig1: Map of Israel southern coastal area, showing Ashkelon District territory and location (reproduced with permission from The Israel Central Bureau of Statistics: http://gis.cbs.gov.il/benyam/).
Mentions: In this cross-sectional study, iodine status was assessed in a convenience sample of volunteers living in the Ashkelon District, Israel, who were prospectively recruited at Barzilai Medical Center in Ashkelon (BMCA). The Ashkelon District and city, where the BMCA is located, are shown in the accompanying map (Figure 1). Volunteers were enrolled over a period of 22 months (from March 2012 to January 2014).

Bottom Line: Conclusions.Elevated serum Tg values and low dietary iodine intake are associated with NNG among adult patients in Ashkelon District, Israel.Larger studies are needed in order to expand on these important initial findings.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine "C", Barzilai Medical Center Ashkelon, Hahistadrout Street 2, 7830604 Ashkelon, Israel ; Nutrition and Brain Health Laboratory, School of Nutritional Sciences, Institute of Biochemistry, Food Science and Nutrition, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, P.O. Box 12, 76100 Rehovot, Israel.

ABSTRACT
Background. Information about iodine intake is crucial for preventing thyroid diseases. Inadequate iodine intake can lead to thyroid diseases, including nontoxic nodular goiter (NNG). Objective. To estimate iodine intake and explore its correlation with thyroid diseases among Israeli adults living near the Mediterranean coast, where iodine-depleted desalinated water has become a major source of drinking water. Methods. Cross-sectional study of patients attending Barzilai Medical Center Ashkelon. Participants, who were classified as either NNG (n = 17), hypothyroidism (n = 14), or control (n = 31), provided serum thyroglobulin (Tg) and completed a semiquantitative iodine food frequency questionnaire. Results. Elevated serum Tg values (Tg > 60 ng/mL) were significantly more prevalent in the NNG group than in the other groups (29% versus 7% and 0% for hypothyroidism and controls, resp., P < 0.05). Mean estimated iodine intake was significantly lower in the NNG group (65 ± 30 μg/d) than in controls (115 ± 60 μg/d) (P < 0.05) with intermediate intake in the hypothyroid group (73 ± 38 μg/d). Conclusions. Elevated serum Tg values and low dietary iodine intake are associated with NNG among adult patients in Ashkelon District, Israel. Larger studies are needed in order to expand on these important initial findings.

No MeSH data available.


Related in: MedlinePlus