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Interocular Shift of Visual Attention Enhances Stereopsis and Visual Acuities of Anisometropic Amblyopes beyond the Critical Period of Visual Development: A Novel Approach.

Huang L, Sun X, Luo G, Liu S, Liu R, Mansouri B, Wong VW, Wen W, Liu H, Wang AH - J Ophthalmol (2014)

Bottom Line: Results.Both Titmus stereopsis (z = -2.809, P = 0.005) and Random-dot stereopsis (z = -2.317, P = 0.018) were significantly improved.Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 83 FenYang Road, Shanghai 200031, China ; Key Laboratory of Myopia, Ministry of Health, Eye & ENT Hospital, Fudan University, 83 FenYang Road, Shanghai 200031, China.

ABSTRACT
Aims. Increasing evidence shows that imbalanced suppressive drive prior to binocular combination may be the key factor in amblyopia. We described a novel binocular approach, interocular shift of visual attention (ISVA), for treatment of amblyopia in adult patients. Methods. Visual stimuli were presented anaglyphically on a computer screen. A square target resembling Landolt C had 2 openings, one in red and one in cyan color. Through blue-red goggles, each eye could only see one of the two openings. The patient was required to report the location of the opening presented to the amblyopic eye. It started at an opening size of 800 sec of arc, went up and down in 160 sec of arc step, and stopped when reaching the 5th reversals. Ten patients with anisometropic amblyopia older than age 14 (average age: 26.7) were recruited and received ISVA treatment for 6 weeks, with 2 training sessions per day. Results. Both Titmus stereopsis (z = -2.809, P = 0.005) and Random-dot stereopsis (z = -2.317, P = 0.018) were significantly improved. Average improvement in best corrected visual acuity (BCVA) was 0.74 line (t = 5.842, P < 0.001). Conclusions. The ISVA treatment may be effective in treating amblyopia and restoring stereoscopic function.

No MeSH data available.


Related in: MedlinePlus

Visual acuity in amblyopic eye before and after the training. The x-axis represents the visual acuity (logMAR) of the subjects before the treatment and the y-axis represents the visual acuity (logMAR) of the subjects after the treatment. Results indicate improvement in visual acuities of the amblyopic eye after the ISVA training (P = 0.000).
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fig5: Visual acuity in amblyopic eye before and after the training. The x-axis represents the visual acuity (logMAR) of the subjects before the treatment and the y-axis represents the visual acuity (logMAR) of the subjects after the treatment. Results indicate improvement in visual acuities of the amblyopic eye after the ISVA training (P = 0.000).

Mentions: We also measured BCVA before and after the training. As seen in Figure 5 and Table 1, in amblyopic eyes, average BCVA before the training was 0.39 ± 0.14, and average BCVA after the training was 0.31 ± 0.14. Improvement in BCVA after ISVA training was 0.74 line (paired t-test: factor of 1, t8 = 5.842, P < 0.001). In the follow eyes, pretraining value was −0.05 ± 0.07 and posttraining value was −0.05 ± 0.07. The BCVA had no changes (paired t-test: factor of 1, t8 = 0.218, P = 0.832).


Interocular Shift of Visual Attention Enhances Stereopsis and Visual Acuities of Anisometropic Amblyopes beyond the Critical Period of Visual Development: A Novel Approach.

Huang L, Sun X, Luo G, Liu S, Liu R, Mansouri B, Wong VW, Wen W, Liu H, Wang AH - J Ophthalmol (2014)

Visual acuity in amblyopic eye before and after the training. The x-axis represents the visual acuity (logMAR) of the subjects before the treatment and the y-axis represents the visual acuity (logMAR) of the subjects after the treatment. Results indicate improvement in visual acuities of the amblyopic eye after the ISVA training (P = 0.000).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4279785&req=5

fig5: Visual acuity in amblyopic eye before and after the training. The x-axis represents the visual acuity (logMAR) of the subjects before the treatment and the y-axis represents the visual acuity (logMAR) of the subjects after the treatment. Results indicate improvement in visual acuities of the amblyopic eye after the ISVA training (P = 0.000).
Mentions: We also measured BCVA before and after the training. As seen in Figure 5 and Table 1, in amblyopic eyes, average BCVA before the training was 0.39 ± 0.14, and average BCVA after the training was 0.31 ± 0.14. Improvement in BCVA after ISVA training was 0.74 line (paired t-test: factor of 1, t8 = 5.842, P < 0.001). In the follow eyes, pretraining value was −0.05 ± 0.07 and posttraining value was −0.05 ± 0.07. The BCVA had no changes (paired t-test: factor of 1, t8 = 0.218, P = 0.832).

Bottom Line: Results.Both Titmus stereopsis (z = -2.809, P = 0.005) and Random-dot stereopsis (z = -2.317, P = 0.018) were significantly improved.Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 83 FenYang Road, Shanghai 200031, China ; Key Laboratory of Myopia, Ministry of Health, Eye & ENT Hospital, Fudan University, 83 FenYang Road, Shanghai 200031, China.

ABSTRACT
Aims. Increasing evidence shows that imbalanced suppressive drive prior to binocular combination may be the key factor in amblyopia. We described a novel binocular approach, interocular shift of visual attention (ISVA), for treatment of amblyopia in adult patients. Methods. Visual stimuli were presented anaglyphically on a computer screen. A square target resembling Landolt C had 2 openings, one in red and one in cyan color. Through blue-red goggles, each eye could only see one of the two openings. The patient was required to report the location of the opening presented to the amblyopic eye. It started at an opening size of 800 sec of arc, went up and down in 160 sec of arc step, and stopped when reaching the 5th reversals. Ten patients with anisometropic amblyopia older than age 14 (average age: 26.7) were recruited and received ISVA treatment for 6 weeks, with 2 training sessions per day. Results. Both Titmus stereopsis (z = -2.809, P = 0.005) and Random-dot stereopsis (z = -2.317, P = 0.018) were significantly improved. Average improvement in best corrected visual acuity (BCVA) was 0.74 line (t = 5.842, P < 0.001). Conclusions. The ISVA treatment may be effective in treating amblyopia and restoring stereoscopic function.

No MeSH data available.


Related in: MedlinePlus