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Interocular Shift of Visual Attention Enhances Stereopsis and Visual Acuities of Anisometropic Amblyopes beyond the Critical Period of Visual Development: A Novel Approach.

Huang L, Sun X, Luo G, Liu S, Liu R, Mansouri B, Wong VW, Wen W, Liu H, Wang AH - J Ophthalmol (2014)

Bottom Line: Results.Both Titmus stereopsis (z = -2.809, P = 0.005) and Random-dot stereopsis (z = -2.317, P = 0.018) were significantly improved.Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 83 FenYang Road, Shanghai 200031, China ; Key Laboratory of Myopia, Ministry of Health, Eye & ENT Hospital, Fudan University, 83 FenYang Road, Shanghai 200031, China.

ABSTRACT
Aims. Increasing evidence shows that imbalanced suppressive drive prior to binocular combination may be the key factor in amblyopia. We described a novel binocular approach, interocular shift of visual attention (ISVA), for treatment of amblyopia in adult patients. Methods. Visual stimuli were presented anaglyphically on a computer screen. A square target resembling Landolt C had 2 openings, one in red and one in cyan color. Through blue-red goggles, each eye could only see one of the two openings. The patient was required to report the location of the opening presented to the amblyopic eye. It started at an opening size of 800 sec of arc, went up and down in 160 sec of arc step, and stopped when reaching the 5th reversals. Ten patients with anisometropic amblyopia older than age 14 (average age: 26.7) were recruited and received ISVA treatment for 6 weeks, with 2 training sessions per day. Results. Both Titmus stereopsis (z = -2.809, P = 0.005) and Random-dot stereopsis (z = -2.317, P = 0.018) were significantly improved. Average improvement in best corrected visual acuity (BCVA) was 0.74 line (t = 5.842, P < 0.001). Conclusions. The ISVA treatment may be effective in treating amblyopia and restoring stereoscopic function.

No MeSH data available.


Related in: MedlinePlus

Random-dot stereogram data before and after the training. The x-axis represents the RDS of the subjects before the treatment and the y-axis represents the RDS of the subjects after the treatment. Stereopsis of Random-dot stereogram was statistically significantly improved (P = 0.018). RDS: Random-dot stereograph. A square outline represents two overlapping data points.
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fig4: Random-dot stereogram data before and after the training. The x-axis represents the RDS of the subjects before the treatment and the y-axis represents the RDS of the subjects after the treatment. Stereopsis of Random-dot stereogram was statistically significantly improved (P = 0.018). RDS: Random-dot stereograph. A square outline represents two overlapping data points.

Mentions: ISVA training led to significantly improvment in stereopsis. As shown in Table 1, ten amblyopic patients participated in this study, 6 males and 4 females. The average age of these patients was 26.7 years (range, 14 to 34 years). Median thresholds of Titmus stereopsis and Random-dot stereopsis were 400 sec (range, 140 to 800 sec) and 500 sec (range, 140 to 800 sec) before the training. Posttraining measurements were taken at 6 weeks. The same measurement procedures were used for pre- and posttraining tests. Median thresholds of Titmus stereopsis and Random-dot stereopsis were 50 sec (range, 40 to 400 sec) and 120 sec (range, 40 to 600 sec) after the training. Figures 3 and 4 showed the comparison of these measurements before and after the training. Notably, 2 patients who had no measurable stereoscopic depth perception in Random-dot stereopsis before the training acquired 200 sec and 600 sec after the training, respectively. Both Titmus stereopsis (Wilcoxon sign rank test: z = −2.809, P = 0.005) and Random-dot stereopsis (Wilcoxon sign rank test: z = −2.317, P = 0.018) were significantly improved after ISVA training.


Interocular Shift of Visual Attention Enhances Stereopsis and Visual Acuities of Anisometropic Amblyopes beyond the Critical Period of Visual Development: A Novel Approach.

Huang L, Sun X, Luo G, Liu S, Liu R, Mansouri B, Wong VW, Wen W, Liu H, Wang AH - J Ophthalmol (2014)

Random-dot stereogram data before and after the training. The x-axis represents the RDS of the subjects before the treatment and the y-axis represents the RDS of the subjects after the treatment. Stereopsis of Random-dot stereogram was statistically significantly improved (P = 0.018). RDS: Random-dot stereograph. A square outline represents two overlapping data points.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4279785&req=5

fig4: Random-dot stereogram data before and after the training. The x-axis represents the RDS of the subjects before the treatment and the y-axis represents the RDS of the subjects after the treatment. Stereopsis of Random-dot stereogram was statistically significantly improved (P = 0.018). RDS: Random-dot stereograph. A square outline represents two overlapping data points.
Mentions: ISVA training led to significantly improvment in stereopsis. As shown in Table 1, ten amblyopic patients participated in this study, 6 males and 4 females. The average age of these patients was 26.7 years (range, 14 to 34 years). Median thresholds of Titmus stereopsis and Random-dot stereopsis were 400 sec (range, 140 to 800 sec) and 500 sec (range, 140 to 800 sec) before the training. Posttraining measurements were taken at 6 weeks. The same measurement procedures were used for pre- and posttraining tests. Median thresholds of Titmus stereopsis and Random-dot stereopsis were 50 sec (range, 40 to 400 sec) and 120 sec (range, 40 to 600 sec) after the training. Figures 3 and 4 showed the comparison of these measurements before and after the training. Notably, 2 patients who had no measurable stereoscopic depth perception in Random-dot stereopsis before the training acquired 200 sec and 600 sec after the training, respectively. Both Titmus stereopsis (Wilcoxon sign rank test: z = −2.809, P = 0.005) and Random-dot stereopsis (Wilcoxon sign rank test: z = −2.317, P = 0.018) were significantly improved after ISVA training.

Bottom Line: Results.Both Titmus stereopsis (z = -2.809, P = 0.005) and Random-dot stereopsis (z = -2.317, P = 0.018) were significantly improved.Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 83 FenYang Road, Shanghai 200031, China ; Key Laboratory of Myopia, Ministry of Health, Eye & ENT Hospital, Fudan University, 83 FenYang Road, Shanghai 200031, China.

ABSTRACT
Aims. Increasing evidence shows that imbalanced suppressive drive prior to binocular combination may be the key factor in amblyopia. We described a novel binocular approach, interocular shift of visual attention (ISVA), for treatment of amblyopia in adult patients. Methods. Visual stimuli were presented anaglyphically on a computer screen. A square target resembling Landolt C had 2 openings, one in red and one in cyan color. Through blue-red goggles, each eye could only see one of the two openings. The patient was required to report the location of the opening presented to the amblyopic eye. It started at an opening size of 800 sec of arc, went up and down in 160 sec of arc step, and stopped when reaching the 5th reversals. Ten patients with anisometropic amblyopia older than age 14 (average age: 26.7) were recruited and received ISVA treatment for 6 weeks, with 2 training sessions per day. Results. Both Titmus stereopsis (z = -2.809, P = 0.005) and Random-dot stereopsis (z = -2.317, P = 0.018) were significantly improved. Average improvement in best corrected visual acuity (BCVA) was 0.74 line (t = 5.842, P < 0.001). Conclusions. The ISVA treatment may be effective in treating amblyopia and restoring stereoscopic function.

No MeSH data available.


Related in: MedlinePlus