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Interocular Shift of Visual Attention Enhances Stereopsis and Visual Acuities of Anisometropic Amblyopes beyond the Critical Period of Visual Development: A Novel Approach.

Huang L, Sun X, Luo G, Liu S, Liu R, Mansouri B, Wong VW, Wen W, Liu H, Wang AH - J Ophthalmol (2014)

Bottom Line: Results.Both Titmus stereopsis (z = -2.809, P = 0.005) and Random-dot stereopsis (z = -2.317, P = 0.018) were significantly improved.Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 83 FenYang Road, Shanghai 200031, China ; Key Laboratory of Myopia, Ministry of Health, Eye & ENT Hospital, Fudan University, 83 FenYang Road, Shanghai 200031, China.

ABSTRACT
Aims. Increasing evidence shows that imbalanced suppressive drive prior to binocular combination may be the key factor in amblyopia. We described a novel binocular approach, interocular shift of visual attention (ISVA), for treatment of amblyopia in adult patients. Methods. Visual stimuli were presented anaglyphically on a computer screen. A square target resembling Landolt C had 2 openings, one in red and one in cyan color. Through blue-red goggles, each eye could only see one of the two openings. The patient was required to report the location of the opening presented to the amblyopic eye. It started at an opening size of 800 sec of arc, went up and down in 160 sec of arc step, and stopped when reaching the 5th reversals. Ten patients with anisometropic amblyopia older than age 14 (average age: 26.7) were recruited and received ISVA treatment for 6 weeks, with 2 training sessions per day. Results. Both Titmus stereopsis (z = -2.809, P = 0.005) and Random-dot stereopsis (z = -2.317, P = 0.018) were significantly improved. Average improvement in best corrected visual acuity (BCVA) was 0.74 line (t = 5.842, P < 0.001). Conclusions. The ISVA treatment may be effective in treating amblyopia and restoring stereoscopic function.

No MeSH data available.


Related in: MedlinePlus

Stimulus paradigm of the interocular shift attention. The top of this diagram shows the training visual stimulus seeing through the anaglyphic glasses (shown in the middle); two eyes see different images (shown at the bottom). The task is to detect the opening direction of the image seen by the amblyopic eye, using a 4-alternative forced-choice (4-AFC) training paradigm.
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fig1: Stimulus paradigm of the interocular shift attention. The top of this diagram shows the training visual stimulus seeing through the anaglyphic glasses (shown in the middle); two eyes see different images (shown at the bottom). The task is to detect the opening direction of the image seen by the amblyopic eye, using a 4-alternative forced-choice (4-AFC) training paradigm.

Mentions: The visual stimuli for ISVA training were presented anaglyphically (Figure 1). The square target mimicked Landolt C. The size of the opening was one-fifth of the whole target. Visual angle of the target could be changed as shown in the staircase paradigm (Figure 2). There were 2 openings: one in red color and one in cyan color. Through blue-red goggles, the red opening was seen only by the eye wearing blue lens and the cyan opening was seen only by the eye wearing red lens. The task was to push one of four arrow keys to indicate the opening direction that was seen by the amblyopic eye. The opening direction was a random 4-alternative forced-choice (4-AFC) each time.


Interocular Shift of Visual Attention Enhances Stereopsis and Visual Acuities of Anisometropic Amblyopes beyond the Critical Period of Visual Development: A Novel Approach.

Huang L, Sun X, Luo G, Liu S, Liu R, Mansouri B, Wong VW, Wen W, Liu H, Wang AH - J Ophthalmol (2014)

Stimulus paradigm of the interocular shift attention. The top of this diagram shows the training visual stimulus seeing through the anaglyphic glasses (shown in the middle); two eyes see different images (shown at the bottom). The task is to detect the opening direction of the image seen by the amblyopic eye, using a 4-alternative forced-choice (4-AFC) training paradigm.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4279785&req=5

fig1: Stimulus paradigm of the interocular shift attention. The top of this diagram shows the training visual stimulus seeing through the anaglyphic glasses (shown in the middle); two eyes see different images (shown at the bottom). The task is to detect the opening direction of the image seen by the amblyopic eye, using a 4-alternative forced-choice (4-AFC) training paradigm.
Mentions: The visual stimuli for ISVA training were presented anaglyphically (Figure 1). The square target mimicked Landolt C. The size of the opening was one-fifth of the whole target. Visual angle of the target could be changed as shown in the staircase paradigm (Figure 2). There were 2 openings: one in red color and one in cyan color. Through blue-red goggles, the red opening was seen only by the eye wearing blue lens and the cyan opening was seen only by the eye wearing red lens. The task was to push one of four arrow keys to indicate the opening direction that was seen by the amblyopic eye. The opening direction was a random 4-alternative forced-choice (4-AFC) each time.

Bottom Line: Results.Both Titmus stereopsis (z = -2.809, P = 0.005) and Random-dot stereopsis (z = -2.317, P = 0.018) were significantly improved.Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 83 FenYang Road, Shanghai 200031, China ; Key Laboratory of Myopia, Ministry of Health, Eye & ENT Hospital, Fudan University, 83 FenYang Road, Shanghai 200031, China.

ABSTRACT
Aims. Increasing evidence shows that imbalanced suppressive drive prior to binocular combination may be the key factor in amblyopia. We described a novel binocular approach, interocular shift of visual attention (ISVA), for treatment of amblyopia in adult patients. Methods. Visual stimuli were presented anaglyphically on a computer screen. A square target resembling Landolt C had 2 openings, one in red and one in cyan color. Through blue-red goggles, each eye could only see one of the two openings. The patient was required to report the location of the opening presented to the amblyopic eye. It started at an opening size of 800 sec of arc, went up and down in 160 sec of arc step, and stopped when reaching the 5th reversals. Ten patients with anisometropic amblyopia older than age 14 (average age: 26.7) were recruited and received ISVA treatment for 6 weeks, with 2 training sessions per day. Results. Both Titmus stereopsis (z = -2.809, P = 0.005) and Random-dot stereopsis (z = -2.317, P = 0.018) were significantly improved. Average improvement in best corrected visual acuity (BCVA) was 0.74 line (t = 5.842, P < 0.001). Conclusions. The ISVA treatment may be effective in treating amblyopia and restoring stereoscopic function.

No MeSH data available.


Related in: MedlinePlus