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Biokinetics of zinc oxide nanoparticles: toxicokinetics, biological fates, and protein interaction.

Choi SJ, Choy JH - Int J Nanomedicine (2014)

Bottom Line: Biokinetic studies of zinc oxide (ZnO) nanoparticles involve systematic and quantitative analyses of absorption, distribution, metabolism, and excretion in plasma and tissues of whole animals after exposure.A full understanding of the biokinetics provides basic information about nanoparticle entry into systemic circulation, target organs of accumulation and toxicity, and elimination time, which is important for predicting the long-term toxic potential of nanoparticles.This review focuses on physicochemical factors affecting the biokinetics of ZnO nanoparticles, in concert with understanding bioavailable fates and their interaction with proteins.

View Article: PubMed Central - PubMed

Affiliation: Department of Food Science and Technology, Seoul Women's University, Seoul, South Korea.

ABSTRACT
Biokinetic studies of zinc oxide (ZnO) nanoparticles involve systematic and quantitative analyses of absorption, distribution, metabolism, and excretion in plasma and tissues of whole animals after exposure. A full understanding of the biokinetics provides basic information about nanoparticle entry into systemic circulation, target organs of accumulation and toxicity, and elimination time, which is important for predicting the long-term toxic potential of nanoparticles. Biokinetic behaviors can be dependent on physicochemical properties, dissolution property in biological fluids, and nanoparticle-protein interaction. Moreover, the determination of biological fates of ZnO nanoparticles in the systemic circulation and tissues is critical in interpreting biokinetic behaviors and predicting toxicity potential as well as mechanism. This review focuses on physicochemical factors affecting the biokinetics of ZnO nanoparticles, in concert with understanding bioavailable fates and their interaction with proteins.

No MeSH data available.


Related in: MedlinePlus

Plasma concentration–time curves of 20 nm zinc oxide (ZnO) nanoparticles after a single oral administration to male rats.
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f1-ijn-9-261: Plasma concentration–time curves of 20 nm zinc oxide (ZnO) nanoparticles after a single oral administration to male rats.

Mentions: Following a single oral administration, plasma concentration versus time profiles of ZnO nanoparticles are highly dependent on exposure dose. When three different doses (50, 300, and 2,000 mg/kg) of two different nanoparticle diameters (20 and 70 nm), dispersed in citrate/4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), were orally administered to rats, all PK parameters, such as, maximum concentration, time to reach maximum concentration (Tmax), area under the plasma concentration–time curve (AUC; a measure of the total amount that reaches the systemic circulation), half-life (t½), and mean residence time (average time that a molecule remains in the body), increased clearly in a dose-dependent manner.25 In particular, the absorption rate and distribution phase were highly dependent on exposure dose, showing Tmax values at 1, 6, and 24 hours after receiving 50, 300, and 2,000 mg/kg, but returned to normal levels within 6, 24, and 96 hours, respectively (Figure 1). Oral absorption efficiency was determined to be about 13%, 25%, and 31%, respectively. Interestingly, no significant differences between particle sizes or sex were demonstrated.


Biokinetics of zinc oxide nanoparticles: toxicokinetics, biological fates, and protein interaction.

Choi SJ, Choy JH - Int J Nanomedicine (2014)

Plasma concentration–time curves of 20 nm zinc oxide (ZnO) nanoparticles after a single oral administration to male rats.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4279768&req=5

f1-ijn-9-261: Plasma concentration–time curves of 20 nm zinc oxide (ZnO) nanoparticles after a single oral administration to male rats.
Mentions: Following a single oral administration, plasma concentration versus time profiles of ZnO nanoparticles are highly dependent on exposure dose. When three different doses (50, 300, and 2,000 mg/kg) of two different nanoparticle diameters (20 and 70 nm), dispersed in citrate/4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), were orally administered to rats, all PK parameters, such as, maximum concentration, time to reach maximum concentration (Tmax), area under the plasma concentration–time curve (AUC; a measure of the total amount that reaches the systemic circulation), half-life (t½), and mean residence time (average time that a molecule remains in the body), increased clearly in a dose-dependent manner.25 In particular, the absorption rate and distribution phase were highly dependent on exposure dose, showing Tmax values at 1, 6, and 24 hours after receiving 50, 300, and 2,000 mg/kg, but returned to normal levels within 6, 24, and 96 hours, respectively (Figure 1). Oral absorption efficiency was determined to be about 13%, 25%, and 31%, respectively. Interestingly, no significant differences between particle sizes or sex were demonstrated.

Bottom Line: Biokinetic studies of zinc oxide (ZnO) nanoparticles involve systematic and quantitative analyses of absorption, distribution, metabolism, and excretion in plasma and tissues of whole animals after exposure.A full understanding of the biokinetics provides basic information about nanoparticle entry into systemic circulation, target organs of accumulation and toxicity, and elimination time, which is important for predicting the long-term toxic potential of nanoparticles.This review focuses on physicochemical factors affecting the biokinetics of ZnO nanoparticles, in concert with understanding bioavailable fates and their interaction with proteins.

View Article: PubMed Central - PubMed

Affiliation: Department of Food Science and Technology, Seoul Women's University, Seoul, South Korea.

ABSTRACT
Biokinetic studies of zinc oxide (ZnO) nanoparticles involve systematic and quantitative analyses of absorption, distribution, metabolism, and excretion in plasma and tissues of whole animals after exposure. A full understanding of the biokinetics provides basic information about nanoparticle entry into systemic circulation, target organs of accumulation and toxicity, and elimination time, which is important for predicting the long-term toxic potential of nanoparticles. Biokinetic behaviors can be dependent on physicochemical properties, dissolution property in biological fluids, and nanoparticle-protein interaction. Moreover, the determination of biological fates of ZnO nanoparticles in the systemic circulation and tissues is critical in interpreting biokinetic behaviors and predicting toxicity potential as well as mechanism. This review focuses on physicochemical factors affecting the biokinetics of ZnO nanoparticles, in concert with understanding bioavailable fates and their interaction with proteins.

No MeSH data available.


Related in: MedlinePlus