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Evaluation of silica nanoparticle toxicity after topical exposure for 90 days.

Ryu HJ, Seong NW, So BJ, Seo HS, Kim JH, Hong JS, Park MK, Kim MS, Kim YR, Cho KB, Seo MY, Kim MK, Maeng EH, Son SW - Int J Nanomedicine (2014)

Bottom Line: Silica is a very common material that can be found in both crystalline and amorphous forms.The majority of in vivo studies of amorphous silica nanoparticles (NPs) were performed using an inhalation exposure method.Unlike the inhalation route or gastrointestinal route, the contact of silica NPs through skin did not result in any toxicity or any change in internal organs up to a dose of 2,000 mg/kg in rats.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Korea University College of Medicine, Seoul, South Korea.

ABSTRACT
Silica is a very common material that can be found in both crystalline and amorphous forms. Well-known toxicities of the lung can occur after exposure to the crystalline form of silica. However, the toxicities of the amorphous form of silica have not been thoroughly studied. The majority of in vivo studies of amorphous silica nanoparticles (NPs) were performed using an inhalation exposure method. Since silica NPs can be commonly administered through the skin, a study of dermal silica toxicity was necessary to determine any harmful effects from dermal exposures. The present study focused on the results of systemic toxicity after applying 20 nm colloidal silica NPs on rat skin for 90 days, in accordance with the Organization for Economic Cooperation and Development test guideline 411 with a good laboratory practice system. Unlike the inhalation route or gastrointestinal route, the contact of silica NPs through skin did not result in any toxicity or any change in internal organs up to a dose of 2,000 mg/kg in rats.

No MeSH data available.


Related in: MedlinePlus

Histopathological findings in the skin and liver after treatment with silica (SiO2) nanoparticles at a dose of 2,000 mg/kg for 90 days.Notes: Skin sections were stained with hematoxylin and eosin (×100): (A) control group, (B) 2,000 mg/kg treatment group. Liver sections were stained with hematoxylin and eosin (×100): (C) Control group, (D) 2,000 mg/kg treatment group. There was no specific change in the skin and liver after treatment with SiO2 nanoparticles at a dose of 2,000 mg/kg for 90 days.
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f1-ijn-9-127: Histopathological findings in the skin and liver after treatment with silica (SiO2) nanoparticles at a dose of 2,000 mg/kg for 90 days.Notes: Skin sections were stained with hematoxylin and eosin (×100): (A) control group, (B) 2,000 mg/kg treatment group. Liver sections were stained with hematoxylin and eosin (×100): (C) Control group, (D) 2,000 mg/kg treatment group. There was no specific change in the skin and liver after treatment with SiO2 nanoparticles at a dose of 2,000 mg/kg for 90 days.

Mentions: Figure 1 shows biopsy findings of the skin and liver after treatment with SiO2 NPs at a dose of 2,000 mg/kg for 90 days. For the biopsy findings of the skin, compared with the control group (Figure 1A), no abnormal change is shown in the SiO2 2,000 mg/kg group (Figure 1B). Biopsy findings of the liver after treatment with SiO2 NPs at a dose of 2,000 mg/kg for 90 days (Figure 1D) also show no change compared with the control group (Figure 1C).


Evaluation of silica nanoparticle toxicity after topical exposure for 90 days.

Ryu HJ, Seong NW, So BJ, Seo HS, Kim JH, Hong JS, Park MK, Kim MS, Kim YR, Cho KB, Seo MY, Kim MK, Maeng EH, Son SW - Int J Nanomedicine (2014)

Histopathological findings in the skin and liver after treatment with silica (SiO2) nanoparticles at a dose of 2,000 mg/kg for 90 days.Notes: Skin sections were stained with hematoxylin and eosin (×100): (A) control group, (B) 2,000 mg/kg treatment group. Liver sections were stained with hematoxylin and eosin (×100): (C) Control group, (D) 2,000 mg/kg treatment group. There was no specific change in the skin and liver after treatment with SiO2 nanoparticles at a dose of 2,000 mg/kg for 90 days.
© Copyright Policy
Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC4279761&req=5

f1-ijn-9-127: Histopathological findings in the skin and liver after treatment with silica (SiO2) nanoparticles at a dose of 2,000 mg/kg for 90 days.Notes: Skin sections were stained with hematoxylin and eosin (×100): (A) control group, (B) 2,000 mg/kg treatment group. Liver sections were stained with hematoxylin and eosin (×100): (C) Control group, (D) 2,000 mg/kg treatment group. There was no specific change in the skin and liver after treatment with SiO2 nanoparticles at a dose of 2,000 mg/kg for 90 days.
Mentions: Figure 1 shows biopsy findings of the skin and liver after treatment with SiO2 NPs at a dose of 2,000 mg/kg for 90 days. For the biopsy findings of the skin, compared with the control group (Figure 1A), no abnormal change is shown in the SiO2 2,000 mg/kg group (Figure 1B). Biopsy findings of the liver after treatment with SiO2 NPs at a dose of 2,000 mg/kg for 90 days (Figure 1D) also show no change compared with the control group (Figure 1C).

Bottom Line: Silica is a very common material that can be found in both crystalline and amorphous forms.The majority of in vivo studies of amorphous silica nanoparticles (NPs) were performed using an inhalation exposure method.Unlike the inhalation route or gastrointestinal route, the contact of silica NPs through skin did not result in any toxicity or any change in internal organs up to a dose of 2,000 mg/kg in rats.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Korea University College of Medicine, Seoul, South Korea.

ABSTRACT
Silica is a very common material that can be found in both crystalline and amorphous forms. Well-known toxicities of the lung can occur after exposure to the crystalline form of silica. However, the toxicities of the amorphous form of silica have not been thoroughly studied. The majority of in vivo studies of amorphous silica nanoparticles (NPs) were performed using an inhalation exposure method. Since silica NPs can be commonly administered through the skin, a study of dermal silica toxicity was necessary to determine any harmful effects from dermal exposures. The present study focused on the results of systemic toxicity after applying 20 nm colloidal silica NPs on rat skin for 90 days, in accordance with the Organization for Economic Cooperation and Development test guideline 411 with a good laboratory practice system. Unlike the inhalation route or gastrointestinal route, the contact of silica NPs through skin did not result in any toxicity or any change in internal organs up to a dose of 2,000 mg/kg in rats.

No MeSH data available.


Related in: MedlinePlus