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Association between vitamin D deficiency and mortality in critically ill adult patients: a meta-analysis of cohort studies.

Zhang YP, Wan YD, Sun TW, Kan QC, Wang LX - Crit Care (2014)

Bottom Line: Mortality-specific odds ratio (OR) with 95% confidence interval (CI) were pooled with a random- or fixed-effect models when appropriate.The finding of increased hospital mortality in critically ill adult patients was consistently found in every stratum of our subgroup analyses.This meta-analysis suggests that vitamin D deficiency is associated with increased incidence of hospital mortality in critically ill adult patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Integrated Intensive Care Unit, the First Affiliated Hospital, Zhengzhou University, 1 Jianshe East Road, Zhengzhou, 450052, China. 1650394713@qq.com.

ABSTRACT

Introduction: Vitamin D deficiency is common in critically ill patients, and was reported to be associated with adverse outcomes. However, the effect of vitamin D deficiency on mortality in critically ill patients remains unclear.

Methods: We searched PubMed and EMBASE from the inception to July 2014 for cohort studies to assess the effect of vitamin D deficiency on the incidence of mortality in critically ill patients. Mortality-specific odds ratio (OR) with 95% confidence interval (CI) were pooled with a random- or fixed-effect models when appropriate.

Results: Seven cohort studies with a total of 4,204 participants including 1,679 cases of vitamin D deficiency were included in this meta-analysis. Vitamin D deficiency was significantly associated with an increased hospital mortality (OR 1.76; 95% CI, 1.38 to 2.24; P < 0.001), with very low heterogeneity (I (2) = 2.3%; P = 0.402). The finding of increased hospital mortality in critically ill adult patients was consistently found in every stratum of our subgroup analyses.

Conclusions: This meta-analysis suggests that vitamin D deficiency is associated with increased incidence of hospital mortality in critically ill adult patients.

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Related in: MedlinePlus

Forest plot showing the effect of vitamin D deficiency on hospital mortality. OR, odds ratio.
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Fig2: Forest plot showing the effect of vitamin D deficiency on hospital mortality. OR, odds ratio.

Mentions: Combined by the fixed-effects model, the multivariable-adjusted OR for hospital mortality and ICU mortality for each study is shown in Figures 2 and 3, respectively. Results from six studies showed that vitamin D deficiency is associated with an increased risk of hospital mortality (OR 1.76; 95% CI, 1.38, 2.24; P <0. 001), with very low heterogeneity among the studies (I2 = 2.3%; P = 0.402). For ICU mortality, there was not enough evidence to conclude that vitamin D deficiency was not associated with increased incidence of ICU mortality in critically ill adult patients (OR 1.43; 95% CI, 0.76, 2.70; P = 0.271). The data for length of ICU stay for every individual study are presented in Table 2.Figure 2


Association between vitamin D deficiency and mortality in critically ill adult patients: a meta-analysis of cohort studies.

Zhang YP, Wan YD, Sun TW, Kan QC, Wang LX - Crit Care (2014)

Forest plot showing the effect of vitamin D deficiency on hospital mortality. OR, odds ratio.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4274763&req=5

Fig2: Forest plot showing the effect of vitamin D deficiency on hospital mortality. OR, odds ratio.
Mentions: Combined by the fixed-effects model, the multivariable-adjusted OR for hospital mortality and ICU mortality for each study is shown in Figures 2 and 3, respectively. Results from six studies showed that vitamin D deficiency is associated with an increased risk of hospital mortality (OR 1.76; 95% CI, 1.38, 2.24; P <0. 001), with very low heterogeneity among the studies (I2 = 2.3%; P = 0.402). For ICU mortality, there was not enough evidence to conclude that vitamin D deficiency was not associated with increased incidence of ICU mortality in critically ill adult patients (OR 1.43; 95% CI, 0.76, 2.70; P = 0.271). The data for length of ICU stay for every individual study are presented in Table 2.Figure 2

Bottom Line: Mortality-specific odds ratio (OR) with 95% confidence interval (CI) were pooled with a random- or fixed-effect models when appropriate.The finding of increased hospital mortality in critically ill adult patients was consistently found in every stratum of our subgroup analyses.This meta-analysis suggests that vitamin D deficiency is associated with increased incidence of hospital mortality in critically ill adult patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Integrated Intensive Care Unit, the First Affiliated Hospital, Zhengzhou University, 1 Jianshe East Road, Zhengzhou, 450052, China. 1650394713@qq.com.

ABSTRACT

Introduction: Vitamin D deficiency is common in critically ill patients, and was reported to be associated with adverse outcomes. However, the effect of vitamin D deficiency on mortality in critically ill patients remains unclear.

Methods: We searched PubMed and EMBASE from the inception to July 2014 for cohort studies to assess the effect of vitamin D deficiency on the incidence of mortality in critically ill patients. Mortality-specific odds ratio (OR) with 95% confidence interval (CI) were pooled with a random- or fixed-effect models when appropriate.

Results: Seven cohort studies with a total of 4,204 participants including 1,679 cases of vitamin D deficiency were included in this meta-analysis. Vitamin D deficiency was significantly associated with an increased hospital mortality (OR 1.76; 95% CI, 1.38 to 2.24; P < 0.001), with very low heterogeneity (I (2) = 2.3%; P = 0.402). The finding of increased hospital mortality in critically ill adult patients was consistently found in every stratum of our subgroup analyses.

Conclusions: This meta-analysis suggests that vitamin D deficiency is associated with increased incidence of hospital mortality in critically ill adult patients.

Show MeSH
Related in: MedlinePlus