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Microemulsion of babassu oil as a natural product to improve human immune system function.

Pessoa RS, França EL, Ribeiro EB, Lanes PK, Chaud NG, Moraes LC, Honorio-França AC - Drug Des Devel Ther (2014)

Bottom Line: The aim of this study was to develop and characterize a babassu oil microemulsion system and determine the effect of this microemulsion on the functional activity of phagocytes.Rheological characterization and preliminary and accelerated stability tests were performed.The babassu oil microemulsion system is an option for future applications, including for vaccine delivery systems.

View Article: PubMed Central - PubMed

Affiliation: Post Graduate Program in Material Science, Federal University of Mato Grosso, Barra do Garças, MT, Brazil.

ABSTRACT

Background: The aim of this study was to develop and characterize a babassu oil microemulsion system and determine the effect of this microemulsion on the functional activity of phagocytes.

Methods: The microemulsion was formulated using distilled water, babassu as the oil phase component, Sorbitan monooleate-Span 80(®) (SP), Polysorbate 80-Tween 80(®) (TW), and 1-butanol (BT). Pseudoternary diagrams were prepared, and microemulsion diagram regions were preselected. Rheological characterization and preliminary and accelerated stability tests were performed. The effect of the microemulsion on the interactions between leukocytes and bacteria was determined by superoxide release, phagocytosis, and microbicidal activity.

Results: The developed formulation SP/TW/BT (4.2/4.8/1.0) was classified as oil/water, showed a Newtonian profile, and had linear viscosity. When we assessed the interaction of the microemulsion or babassu oil with phagocytes, we observed an increase in superoxide, phagocytosis, and microbicidal activity.

Conclusion: The babassu oil microemulsion system is an option for future applications, including for vaccine delivery systems. Babassu oil is a natural product, so is an alternative for future immunotherapy strategies, in particular for infectious diseases.

No MeSH data available.


Related in: MedlinePlus

Diagram of the pseudoternary classification of all 36 points in pre-established proportions (A) and domains with points selected for the study system SP/TW/BT (B).Abbreviations: MEL, microemulsion liquid; MEG, microemulsion gel; EG, emulsion gel; SF, phase separation; SP, Sorbitan monooleate-Span 80®; TW, Polysorbate 80-Tween 80®; BT, 1-butanol.
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f1-dddt-9-021: Diagram of the pseudoternary classification of all 36 points in pre-established proportions (A) and domains with points selected for the study system SP/TW/BT (B).Abbreviations: MEL, microemulsion liquid; MEG, microemulsion gel; EG, emulsion gel; SF, phase separation; SP, Sorbitan monooleate-Span 80®; TW, Polysorbate 80-Tween 80®; BT, 1-butanol.

Mentions: Pseudoternary phase diagrams were assembled to classify the points, and domains of each region are demonstrated in Figure 1. The SP/TW/BT (4.2/4.8/1.0) surfactant mixture was compared with babassu oil and distilled water in proportions that were established by the diagram; these data resulted in 36 points with divergent equilibrium characteristics. It was observed that with over 40% of surfactants, the thermodynamic equilibrium became efficient because homogeneous and translucent systems predominated (Figure 1A).


Microemulsion of babassu oil as a natural product to improve human immune system function.

Pessoa RS, França EL, Ribeiro EB, Lanes PK, Chaud NG, Moraes LC, Honorio-França AC - Drug Des Devel Ther (2014)

Diagram of the pseudoternary classification of all 36 points in pre-established proportions (A) and domains with points selected for the study system SP/TW/BT (B).Abbreviations: MEL, microemulsion liquid; MEG, microemulsion gel; EG, emulsion gel; SF, phase separation; SP, Sorbitan monooleate-Span 80®; TW, Polysorbate 80-Tween 80®; BT, 1-butanol.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4274040&req=5

f1-dddt-9-021: Diagram of the pseudoternary classification of all 36 points in pre-established proportions (A) and domains with points selected for the study system SP/TW/BT (B).Abbreviations: MEL, microemulsion liquid; MEG, microemulsion gel; EG, emulsion gel; SF, phase separation; SP, Sorbitan monooleate-Span 80®; TW, Polysorbate 80-Tween 80®; BT, 1-butanol.
Mentions: Pseudoternary phase diagrams were assembled to classify the points, and domains of each region are demonstrated in Figure 1. The SP/TW/BT (4.2/4.8/1.0) surfactant mixture was compared with babassu oil and distilled water in proportions that were established by the diagram; these data resulted in 36 points with divergent equilibrium characteristics. It was observed that with over 40% of surfactants, the thermodynamic equilibrium became efficient because homogeneous and translucent systems predominated (Figure 1A).

Bottom Line: The aim of this study was to develop and characterize a babassu oil microemulsion system and determine the effect of this microemulsion on the functional activity of phagocytes.Rheological characterization and preliminary and accelerated stability tests were performed.The babassu oil microemulsion system is an option for future applications, including for vaccine delivery systems.

View Article: PubMed Central - PubMed

Affiliation: Post Graduate Program in Material Science, Federal University of Mato Grosso, Barra do Garças, MT, Brazil.

ABSTRACT

Background: The aim of this study was to develop and characterize a babassu oil microemulsion system and determine the effect of this microemulsion on the functional activity of phagocytes.

Methods: The microemulsion was formulated using distilled water, babassu as the oil phase component, Sorbitan monooleate-Span 80(®) (SP), Polysorbate 80-Tween 80(®) (TW), and 1-butanol (BT). Pseudoternary diagrams were prepared, and microemulsion diagram regions were preselected. Rheological characterization and preliminary and accelerated stability tests were performed. The effect of the microemulsion on the interactions between leukocytes and bacteria was determined by superoxide release, phagocytosis, and microbicidal activity.

Results: The developed formulation SP/TW/BT (4.2/4.8/1.0) was classified as oil/water, showed a Newtonian profile, and had linear viscosity. When we assessed the interaction of the microemulsion or babassu oil with phagocytes, we observed an increase in superoxide, phagocytosis, and microbicidal activity.

Conclusion: The babassu oil microemulsion system is an option for future applications, including for vaccine delivery systems. Babassu oil is a natural product, so is an alternative for future immunotherapy strategies, in particular for infectious diseases.

No MeSH data available.


Related in: MedlinePlus