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Effect of proinflammatory cytokines (IL-6, TNF-α, and IL-1β) on clinical manifestations in Indian SLE patients.

Umare V, Pradhan V, Nadkar M, Rajadhyaksha A, Patwardhan M, Ghosh KK, Nadkarni AH - Mediators Inflamm. (2014)

Bottom Line: Mean levels of IL-6, TNF-α, and IL-1β were found to be significantly higher in SLE patients than healthy controls (P < 0.001).Mean level of IL-6 for patients with active disease (70.45±68.32 pg/mL) was significantly higher (P = 0.0430) than those of inactive disease patients (43.85±63.36 pg/mL).Similar results were obtained for IL-1β (P = 0.0002).

View Article: PubMed Central - PubMed

Affiliation: National Institute of Immunohaematology, Indian Council of Medical Research, Mumbai, Maharashtra 400012, India.

ABSTRACT
Systemic lupus erythematosus (SLE) is an inflammatory rheumatic disease characterized by production of autoantibodies and organ damage. Elevated levels of cytokines have been reported in SLE patients. In this study we have investigated the effect of proinflammatory cytokines (IL-6, TNF-α, and IL-1β) on clinical manifestations in 145 Indian SLE patients. One hundred and forty-five healthy controls of the same ethnicity served as a control group. Clinical disease activity was scored according to SLEDAI score. Accordingly, 110 patients had active disease and 35 patients had inactive disease. Mean levels of IL-6, TNF-α, and IL-1β were found to be significantly higher in SLE patients than healthy controls (P < 0.001). Mean level of IL-6 for patients with active disease (70.45±68.32 pg/mL) was significantly higher (P = 0.0430) than those of inactive disease patients (43.85±63.36 pg/mL). Mean level of TNF-α was 44.76±68.32 pg/mL for patients with active disease while it was 25.97±22.03 pg/mL for those with inactive disease and this difference was statistically significant (P = 0.0161). Similar results were obtained for IL-1β (P = 0.0002). Correlation between IL-6, TNF-α, and IL-1β serum levels and SLEDAI score was observed (r = 0.20, r = 0.27, and r = 0.38, resp.). This study supports the role of these proinflammatory cytokines as inflammatory mediators in active stage of disease.

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Related in: MedlinePlus

Distribution of serum cytokine levels in SLE patients with active and inactive disease along with healthy controls.
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Related In: Results  -  Collection


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fig1: Distribution of serum cytokine levels in SLE patients with active and inactive disease along with healthy controls.

Mentions: Serum levels of cytokines IL-6, TNF-α, and IL-1β were measured in all 145 SLE patients and 145 healthy individuals by cytokine multiplex assay. Figure 1 shows the distribution of serum cytokine levels among patients and control groups. The mean level of IL-6 in SLE patients was 4.5 times higher (63.00 ± 67.28 pg/mL) as compared to controls (14.13 ± 8.61 pg/mL). This difference was statistically significant as compared with healthy individuals (P < 0.0001). The serum IL-6 level was significantly higher in active SLE patients (70.45 ± 68.32 pg/mL) as compared to inactive disease (43.83 ± 63.36 pg/mL, P = 0.0430) (Figure 1(a)).


Effect of proinflammatory cytokines (IL-6, TNF-α, and IL-1β) on clinical manifestations in Indian SLE patients.

Umare V, Pradhan V, Nadkar M, Rajadhyaksha A, Patwardhan M, Ghosh KK, Nadkarni AH - Mediators Inflamm. (2014)

Distribution of serum cytokine levels in SLE patients with active and inactive disease along with healthy controls.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4273527&req=5

fig1: Distribution of serum cytokine levels in SLE patients with active and inactive disease along with healthy controls.
Mentions: Serum levels of cytokines IL-6, TNF-α, and IL-1β were measured in all 145 SLE patients and 145 healthy individuals by cytokine multiplex assay. Figure 1 shows the distribution of serum cytokine levels among patients and control groups. The mean level of IL-6 in SLE patients was 4.5 times higher (63.00 ± 67.28 pg/mL) as compared to controls (14.13 ± 8.61 pg/mL). This difference was statistically significant as compared with healthy individuals (P < 0.0001). The serum IL-6 level was significantly higher in active SLE patients (70.45 ± 68.32 pg/mL) as compared to inactive disease (43.83 ± 63.36 pg/mL, P = 0.0430) (Figure 1(a)).

Bottom Line: Mean levels of IL-6, TNF-α, and IL-1β were found to be significantly higher in SLE patients than healthy controls (P < 0.001).Mean level of IL-6 for patients with active disease (70.45±68.32 pg/mL) was significantly higher (P = 0.0430) than those of inactive disease patients (43.85±63.36 pg/mL).Similar results were obtained for IL-1β (P = 0.0002).

View Article: PubMed Central - PubMed

Affiliation: National Institute of Immunohaematology, Indian Council of Medical Research, Mumbai, Maharashtra 400012, India.

ABSTRACT
Systemic lupus erythematosus (SLE) is an inflammatory rheumatic disease characterized by production of autoantibodies and organ damage. Elevated levels of cytokines have been reported in SLE patients. In this study we have investigated the effect of proinflammatory cytokines (IL-6, TNF-α, and IL-1β) on clinical manifestations in 145 Indian SLE patients. One hundred and forty-five healthy controls of the same ethnicity served as a control group. Clinical disease activity was scored according to SLEDAI score. Accordingly, 110 patients had active disease and 35 patients had inactive disease. Mean levels of IL-6, TNF-α, and IL-1β were found to be significantly higher in SLE patients than healthy controls (P < 0.001). Mean level of IL-6 for patients with active disease (70.45±68.32 pg/mL) was significantly higher (P = 0.0430) than those of inactive disease patients (43.85±63.36 pg/mL). Mean level of TNF-α was 44.76±68.32 pg/mL for patients with active disease while it was 25.97±22.03 pg/mL for those with inactive disease and this difference was statistically significant (P = 0.0161). Similar results were obtained for IL-1β (P = 0.0002). Correlation between IL-6, TNF-α, and IL-1β serum levels and SLEDAI score was observed (r = 0.20, r = 0.27, and r = 0.38, resp.). This study supports the role of these proinflammatory cytokines as inflammatory mediators in active stage of disease.

Show MeSH
Related in: MedlinePlus